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Induction of myocarditis in rabbits injected with group A streptococci

Burova, LA; Nagornev, VA; Pigarevsky, PV; Gladilina, MM; Molchanova, IV; Gavrilova, EA; Totolian, AA; Thern, A and Schalén, Claës LU (2004) In Indian Journal of Medical Research 119. p.183-185
Abstract
Background & objectives: We have earlier proposed that group A streptococcal (GAS) immunoglobulin binding surface proteins (IgGBPs) might trigger anti-IgG production and immune complex formation leading to glomerulonephritis. In the present study, cardiac tissue material from rabbits injected with heat-killed GAS was investigated. Methods: Rabbits were injected intravenously with 10(9) colony forming units of streptococci three times weekly for 8 wk. Cardiac tissue samples were obtained at different times and deposition of IgG, C3, TNF-alpha and IL-6 was studied. Results: After 8 or more weeks of intravenous (iv) injections, minimal changes were seen in animals receiving an IgG non-binding GAS strain, type T27, whereas in those animals... (More)
Background & objectives: We have earlier proposed that group A streptococcal (GAS) immunoglobulin binding surface proteins (IgGBPs) might trigger anti-IgG production and immune complex formation leading to glomerulonephritis. In the present study, cardiac tissue material from rabbits injected with heat-killed GAS was investigated. Methods: Rabbits were injected intravenously with 10(9) colony forming units of streptococci three times weekly for 8 wk. Cardiac tissue samples were obtained at different times and deposition of IgG, C3, TNF-alpha and IL-6 was studied. Results: After 8 or more weeks of intravenous (iv) injections, minimal changes were seen in animals receiving an IgG non-binding GAS strain, type T27, whereas in those animals receiving either of two IgG binding GAS strains, types M1 or M22, strong inflammatory and degenerative myocardial changes accompanied by deposition of IgG and C3 were noted. Furthermore, on injecting rabbits with defined mutants of a type M22 strain, the development of myocardial tissue damage proved to. be dependent on the presence streptococcal IgGBPs. Interpretation & conclusion: The present data supported a role of streptococcal IgGBPs in the induction of myocardial tissue injury by GAS. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Streptococcus, IgG binding protein, anti-IgG, experimental carditis, pyogenes
in
Indian Journal of Medical Research
volume
119
pages
183 - 185
publisher
Council Of Medical Research
external identifiers
  • wos:000222679400042
  • pmid:15232191
  • scopus:3442883633
ISSN
0971-5916
language
English
LU publication?
yes
id
92cb66ab-b54a-4d4e-864b-8677fb324f4c (old id 272838)
alternative location
http://www.icmr.nic.in/ijmr/ijmr_supp/40.pdf
date added to LUP
2007-10-17 14:14:05
date last changed
2017-01-01 06:38:23
@article{92cb66ab-b54a-4d4e-864b-8677fb324f4c,
  abstract     = {Background & objectives: We have earlier proposed that group A streptococcal (GAS) immunoglobulin binding surface proteins (IgGBPs) might trigger anti-IgG production and immune complex formation leading to glomerulonephritis. In the present study, cardiac tissue material from rabbits injected with heat-killed GAS was investigated. Methods: Rabbits were injected intravenously with 10(9) colony forming units of streptococci three times weekly for 8 wk. Cardiac tissue samples were obtained at different times and deposition of IgG, C3, TNF-alpha and IL-6 was studied. Results: After 8 or more weeks of intravenous (iv) injections, minimal changes were seen in animals receiving an IgG non-binding GAS strain, type T27, whereas in those animals receiving either of two IgG binding GAS strains, types M1 or M22, strong inflammatory and degenerative myocardial changes accompanied by deposition of IgG and C3 were noted. Furthermore, on injecting rabbits with defined mutants of a type M22 strain, the development of myocardial tissue damage proved to. be dependent on the presence streptococcal IgGBPs. Interpretation & conclusion: The present data supported a role of streptococcal IgGBPs in the induction of myocardial tissue injury by GAS.},
  author       = {Burova, LA and Nagornev, VA and Pigarevsky, PV and Gladilina, MM and Molchanova, IV and Gavrilova, EA and Totolian, AA and Thern, A and Schalén, Claës},
  issn         = {0971-5916},
  keyword      = {Streptococcus,IgG binding protein,anti-IgG,experimental carditis,pyogenes},
  language     = {eng},
  pages        = {183--185},
  publisher    = {Council Of Medical Research},
  series       = {Indian Journal of Medical Research},
  title        = {Induction of myocarditis in rabbits injected with group A streptococci},
  volume       = {119},
  year         = {2004},
}