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Caveolae-associated signalling in smooth muscle

Bergdahl, Andreas LU and Swärd, Karl LU (2004) In Canadian Journal of Physiology and Pharmacology 82(5). p.289-299
Abstract
Caveolae are flask-shaped invaginations in the membrane that depend on the contents of cholesterol and on the structural protein caveolin. The organisation of caveolae in parallel strands between dense bands in smooth muscle is arguably unique. It is increasingly recognised, bolstered in large part by recent studies in caveolae deficient animals, that caveolae sequester and regulate a variety of signalling intermediaries. The role of caveolae in smooth muscle signal transduction, as inferred from studies on transgenic animals and in vitro approaches, is the topic of the current review. Both G-protein coupled receptors and tyrosine kinase receptors are believed to cluster in caveolae, and the exciting possibility that caveolae provide a... (More)
Caveolae are flask-shaped invaginations in the membrane that depend on the contents of cholesterol and on the structural protein caveolin. The organisation of caveolae in parallel strands between dense bands in smooth muscle is arguably unique. It is increasingly recognised, bolstered in large part by recent studies in caveolae deficient animals, that caveolae sequester and regulate a variety of signalling intermediaries. The role of caveolae in smooth muscle signal transduction, as inferred from studies on transgenic animals and in vitro approaches, is the topic of the current review. Both G-protein coupled receptors and tyrosine kinase receptors are believed to cluster in caveolae, and the exciting possibility that caveolae provide a platform for interactions between the sarcoplasmic reticulum and plasmalemmal ion channels is emerging. Moreover, messengers involved in Ca2+ sensitization of myosin phosphorylation and contraction may depend on caveolae or caveolin. Caveolae thus appear to constitute an important signalling domain that plays a role not only in regulation of smooth muscle tone, but also in proliferation, such as seen in neointima formation and atherosclerosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
spontaneous transient outward currents, endothelin, transient receptor potential channel, caveolin, RhoA
in
Canadian Journal of Physiology and Pharmacology
volume
82
issue
5
pages
289 - 299
publisher
National Research Council Canada
external identifiers
  • pmid:15213728
  • wos:000222349700002
  • scopus:4143086109
ISSN
0008-4212
DOI
10.1139/y04-033
language
English
LU publication?
yes
id
df777bdf-802c-456a-bc59-3f2104401d74 (old id 273590)
date added to LUP
2007-10-17 08:26:27
date last changed
2017-01-01 05:08:22
@article{df777bdf-802c-456a-bc59-3f2104401d74,
  abstract     = {Caveolae are flask-shaped invaginations in the membrane that depend on the contents of cholesterol and on the structural protein caveolin. The organisation of caveolae in parallel strands between dense bands in smooth muscle is arguably unique. It is increasingly recognised, bolstered in large part by recent studies in caveolae deficient animals, that caveolae sequester and regulate a variety of signalling intermediaries. The role of caveolae in smooth muscle signal transduction, as inferred from studies on transgenic animals and in vitro approaches, is the topic of the current review. Both G-protein coupled receptors and tyrosine kinase receptors are believed to cluster in caveolae, and the exciting possibility that caveolae provide a platform for interactions between the sarcoplasmic reticulum and plasmalemmal ion channels is emerging. Moreover, messengers involved in Ca2+ sensitization of myosin phosphorylation and contraction may depend on caveolae or caveolin. Caveolae thus appear to constitute an important signalling domain that plays a role not only in regulation of smooth muscle tone, but also in proliferation, such as seen in neointima formation and atherosclerosis.},
  author       = {Bergdahl, Andreas and Swärd, Karl},
  issn         = {0008-4212},
  keyword      = {spontaneous transient outward currents,endothelin,transient receptor potential channel,caveolin,RhoA},
  language     = {eng},
  number       = {5},
  pages        = {289--299},
  publisher    = {National Research Council Canada},
  series       = {Canadian Journal of Physiology and Pharmacology},
  title        = {Caveolae-associated signalling in smooth muscle},
  url          = {http://dx.doi.org/10.1139/y04-033},
  volume       = {82},
  year         = {2004},
}