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Congenital oral mucosal abnormalities in true umbilical cord knots

De Felice, C; Bianciardi, G; Parrini, S; Laurini, Ricardo LU and Latini, G (2004) In Biology of the Neonate 86(1). p.34-38
Abstract
Objective: The pathogenesis and clinical significance of true umbilical cord knots remain controversial. Here, we tested the hypothesis of the presence of congenital oral mucosal changes in newborns with true umbilical cord knots. Study design: Seven consecutive infants with true umbilical cord knots and 50 gestational age- and sex-matched controls were enrolled. The proportion of oral frenulum abnormalities and the two-dimensional vascular network geometry [fractal dimension, D, at two scales: D(1-46), and D(1-15), with the relative Lempel-Ziv complexity, (L-Z)], were analyzed. Results: Infants with true umbilical cord knots showed significantly higher proportions of mandibular frenulum agenesis compared to controls (p = 0.000006). The... (More)
Objective: The pathogenesis and clinical significance of true umbilical cord knots remain controversial. Here, we tested the hypothesis of the presence of congenital oral mucosal changes in newborns with true umbilical cord knots. Study design: Seven consecutive infants with true umbilical cord knots and 50 gestational age- and sex-matched controls were enrolled. The proportion of oral frenulum abnormalities and the two-dimensional vascular network geometry [fractal dimension, D, at two scales: D(1-46), and D(1-15), with the relative Lempel-Ziv complexity, (L-Z)], were analyzed. Results: Infants with true umbilical cord knots showed significantly higher proportions of mandibular frenulum agenesis compared to controls (p = 0.000006). The oral vascular networks of these infants exhibited a significantly higher D(1-46) and D(1-15) (p < 0.0001, respectively), and higher L-Z values (p < 0.0001) than control networks. Conclusion: These findings indicate the presence of significant congenital oral mucosal changes in newborn infants with true umbilical cord knots, thus suggesting a previously unrecognized association between true umbilical cord knots and a subclinical extracellular matrix disorder. Copyright (C) 2004 S. Karger AG, Basel. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
umbilical cord, abnormalities, labial frenum, frenulum, fractal geometry, blood vessels, complexity
in
Biology of the Neonate
volume
86
issue
1
pages
34 - 38
publisher
Karger
external identifiers
  • wos:000222387700007
  • pmid:15026617
  • scopus:4043183943
ISSN
1421-9727
DOI
10.1159/000077333
language
English
LU publication?
yes
id
713976dc-3521-4067-bc4e-f7dd05deb0d4 (old id 273598)
date added to LUP
2007-10-23 10:00:54
date last changed
2017-11-28 14:50:35
@article{713976dc-3521-4067-bc4e-f7dd05deb0d4,
  abstract     = {Objective: The pathogenesis and clinical significance of true umbilical cord knots remain controversial. Here, we tested the hypothesis of the presence of congenital oral mucosal changes in newborns with true umbilical cord knots. Study design: Seven consecutive infants with true umbilical cord knots and 50 gestational age- and sex-matched controls were enrolled. The proportion of oral frenulum abnormalities and the two-dimensional vascular network geometry [fractal dimension, D, at two scales: D(1-46), and D(1-15), with the relative Lempel-Ziv complexity, (L-Z)], were analyzed. Results: Infants with true umbilical cord knots showed significantly higher proportions of mandibular frenulum agenesis compared to controls (p = 0.000006). The oral vascular networks of these infants exhibited a significantly higher D(1-46) and D(1-15) (p &lt; 0.0001, respectively), and higher L-Z values (p &lt; 0.0001) than control networks. Conclusion: These findings indicate the presence of significant congenital oral mucosal changes in newborn infants with true umbilical cord knots, thus suggesting a previously unrecognized association between true umbilical cord knots and a subclinical extracellular matrix disorder. Copyright (C) 2004 S. Karger AG, Basel.},
  author       = {De Felice, C and Bianciardi, G and Parrini, S and Laurini, Ricardo and Latini, G},
  issn         = {1421-9727},
  keyword      = {umbilical cord,abnormalities,labial frenum,frenulum,fractal geometry,blood vessels,complexity},
  language     = {eng},
  number       = {1},
  pages        = {34--38},
  publisher    = {Karger},
  series       = {Biology of the Neonate},
  title        = {Congenital oral mucosal abnormalities in true umbilical cord knots},
  url          = {http://dx.doi.org/10.1159/000077333},
  volume       = {86},
  year         = {2004},
}