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Phylogenetic analysis of the vertebrate galectin family

Houzelstein, D; Goncalves, IR; Fadden, AJ; Sidhu, SS; Cooper, DNW; Drickamer, K; Leffler, Hakon LU and Poirier, F (2004) In Molecular Biology and Evolution 21(7). p.1177-1187
Abstract
Galectins form a family of structurally related carbohydrate binding proteins (lectins) that have been identified in a large variety of metazoan phyla. They are involved in many biological processes such as morphogenesis, control of cell death, immunological response, and cancer. To elucidate the evolutionary history of galectins and galectin-like proteins in chordates, we have exploited three independent lines of evidence: (i) location of galectin encoding genes (LGALS) in the human genome; (ii) exon-intron organization of galectin encoding genes; and (iii) sequence comparison of carbohydrate recognition domains (CRDs) of chordate galectins. Our results suggest that a duplication of a mono-CRD galectin gene gave rise to an original bi-CRD... (More)
Galectins form a family of structurally related carbohydrate binding proteins (lectins) that have been identified in a large variety of metazoan phyla. They are involved in many biological processes such as morphogenesis, control of cell death, immunological response, and cancer. To elucidate the evolutionary history of galectins and galectin-like proteins in chordates, we have exploited three independent lines of evidence: (i) location of galectin encoding genes (LGALS) in the human genome; (ii) exon-intron organization of galectin encoding genes; and (iii) sequence comparison of carbohydrate recognition domains (CRDs) of chordate galectins. Our results suggest that a duplication of a mono-CRD galectin gene gave rise to an original bi-CRD galectin gene, before or early in chordate evolution. The N-terminal and C-terminal CRDs of this original galectin subsequently diverged into two different subtypes, defined by exon-intron structure (F4-CRD and F3-CRD). We show that all vertebrate mono-CRD galectins known to date belong to either the F3- or F4-subtype. A sequence of duplication and divergence events of the different galectins in chordates is proposed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chordate, vertebrate, galectin, Lgals, evolution
in
Molecular Biology and Evolution
volume
21
issue
7
pages
1177 - 1187
publisher
Oxford University Press
external identifiers
  • wos:000222334300003
  • pmid:14963092
  • scopus:3042643773
ISSN
0737-4038
DOI
10.1093/molbev/msh082
language
English
LU publication?
yes
id
3c0bfb32-a908-4e71-8126-c442eead250f (old id 273762)
date added to LUP
2007-10-26 16:14:56
date last changed
2017-10-01 03:36:21
@article{3c0bfb32-a908-4e71-8126-c442eead250f,
  abstract     = {Galectins form a family of structurally related carbohydrate binding proteins (lectins) that have been identified in a large variety of metazoan phyla. They are involved in many biological processes such as morphogenesis, control of cell death, immunological response, and cancer. To elucidate the evolutionary history of galectins and galectin-like proteins in chordates, we have exploited three independent lines of evidence: (i) location of galectin encoding genes (LGALS) in the human genome; (ii) exon-intron organization of galectin encoding genes; and (iii) sequence comparison of carbohydrate recognition domains (CRDs) of chordate galectins. Our results suggest that a duplication of a mono-CRD galectin gene gave rise to an original bi-CRD galectin gene, before or early in chordate evolution. The N-terminal and C-terminal CRDs of this original galectin subsequently diverged into two different subtypes, defined by exon-intron structure (F4-CRD and F3-CRD). We show that all vertebrate mono-CRD galectins known to date belong to either the F3- or F4-subtype. A sequence of duplication and divergence events of the different galectins in chordates is proposed.},
  author       = {Houzelstein, D and Goncalves, IR and Fadden, AJ and Sidhu, SS and Cooper, DNW and Drickamer, K and Leffler, Hakon and Poirier, F},
  issn         = {0737-4038},
  keyword      = {chordate,vertebrate,galectin,Lgals,evolution},
  language     = {eng},
  number       = {7},
  pages        = {1177--1187},
  publisher    = {Oxford University Press},
  series       = {Molecular Biology and Evolution},
  title        = {Phylogenetic analysis of the vertebrate galectin family},
  url          = {http://dx.doi.org/10.1093/molbev/msh082},
  volume       = {21},
  year         = {2004},
}