Advanced

Haemodynamic effects of erythrocyte transfusion in preterm infants

Leipala, JA; Boldt, T and Fellman, Vineta LU (2004) In European Journal of Pediatrics 163(7). p.390-394
Abstract
The aim of the study was to assess the short-term cardiorespiratory effects of a standard red cell transfusion in very low birth weight (<1500 g) infants undergoing intensive care. A total of 37 infants (birth weight 920+/-230 g, gestational age 27.8+/-2.1 weeks, age at study 6.1+/-3.9 days) with indwelling arterial lines were studied when 10 ml/kg of packed donor red cells were transfused based on clinical judgment. Infants with patent ductus arteriosus and/or inotropic treatment were excluded from the study. Oxygen saturation, left ventricular output, stroke volume, systolic, diastolic and mean arterial pressure, heart rate, and capillary refill time were assessed immediately prior to the transfusion and within an hour after the... (More)
The aim of the study was to assess the short-term cardiorespiratory effects of a standard red cell transfusion in very low birth weight (<1500 g) infants undergoing intensive care. A total of 37 infants (birth weight 920+/-230 g, gestational age 27.8+/-2.1 weeks, age at study 6.1+/-3.9 days) with indwelling arterial lines were studied when 10 ml/kg of packed donor red cells were transfused based on clinical judgment. Infants with patent ductus arteriosus and/or inotropic treatment were excluded from the study. Oxygen saturation, left ventricular output, stroke volume, systolic, diastolic and mean arterial pressure, heart rate, and capillary refill time were assessed immediately prior to the transfusion and within an hour after the transfusion was completed. Capillary refill time after the transfusion was significantly shorter than prior to the transfusion (2.1+/-0.9 versus 2.4+/-1.0 s, P =0.033). Left ventricular output, stroke volume and arterial pressures remained unaltered. Oxygen saturation after the transfusion was lower than before the transfusion (94.0+/-3.8 versus 95.3+/-2.5%, P =0.014) despite unaltered oxygen supply. Conclusion: the data suggest that although a red cell transfusion of 10 ml/kg may marginally improve peripheral perfusion, it does not influence cardiac output and arterial blood pressure in normotensive preterm infants. It may, however, cause a transient decrease in oxygen saturation. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
very low birth, neonate, capillary refill time, left ventricular output, weight
in
European Journal of Pediatrics
volume
163
issue
7
pages
390 - 394
publisher
Springer
external identifiers
  • wos:000222239900009
  • pmid:15085428
  • scopus:3142753574
ISSN
1432-1076
DOI
10.1007/s00431-004-1448-3
language
English
LU publication?
yes
id
32ee927e-f118-41b2-8eb2-4c25220582f1 (old id 274315)
date added to LUP
2007-10-24 10:49:06
date last changed
2017-01-01 05:09:22
@article{32ee927e-f118-41b2-8eb2-4c25220582f1,
  abstract     = {The aim of the study was to assess the short-term cardiorespiratory effects of a standard red cell transfusion in very low birth weight (&lt;1500 g) infants undergoing intensive care. A total of 37 infants (birth weight 920+/-230 g, gestational age 27.8+/-2.1 weeks, age at study 6.1+/-3.9 days) with indwelling arterial lines were studied when 10 ml/kg of packed donor red cells were transfused based on clinical judgment. Infants with patent ductus arteriosus and/or inotropic treatment were excluded from the study. Oxygen saturation, left ventricular output, stroke volume, systolic, diastolic and mean arterial pressure, heart rate, and capillary refill time were assessed immediately prior to the transfusion and within an hour after the transfusion was completed. Capillary refill time after the transfusion was significantly shorter than prior to the transfusion (2.1+/-0.9 versus 2.4+/-1.0 s, P =0.033). Left ventricular output, stroke volume and arterial pressures remained unaltered. Oxygen saturation after the transfusion was lower than before the transfusion (94.0+/-3.8 versus 95.3+/-2.5%, P =0.014) despite unaltered oxygen supply. Conclusion: the data suggest that although a red cell transfusion of 10 ml/kg may marginally improve peripheral perfusion, it does not influence cardiac output and arterial blood pressure in normotensive preterm infants. It may, however, cause a transient decrease in oxygen saturation.},
  author       = {Leipala, JA and Boldt, T and Fellman, Vineta},
  issn         = {1432-1076},
  keyword      = {very low birth,neonate,capillary refill time,left ventricular output,weight},
  language     = {eng},
  number       = {7},
  pages        = {390--394},
  publisher    = {Springer},
  series       = {European Journal of Pediatrics},
  title        = {Haemodynamic effects of erythrocyte transfusion in preterm infants},
  url          = {http://dx.doi.org/10.1007/s00431-004-1448-3},
  volume       = {163},
  year         = {2004},
}