Advanced

Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice

Zhou, ZJ; Doi, M; Wang, JM; Cao, RH; Liu, BH; Chan, KM; Kortesmaa, J; Sorokin, Lydia LU ; Cao, YH and Tryggvason, K (2004) In Cancer Research 64(12). p.4059-4063
Abstract
Laminin-8 (alpha4beta1gamma1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin alpha4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The higher tumor growth rates in mutant mice correlate with decreased tumor cell apoptosis. Depletion of laminin alpha4 chain may alter the structure of vascular basement membranes, leading to increased angiogenesis. Our data suggest that the laminin-8 plays a critical role in the regulation of pathological angiogenesis.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Research
volume
64
issue
12
pages
4059 - 4063
publisher
American Association for Cancer Research Inc.
external identifiers
  • pmid:15205311
  • wos:000222077900001
  • scopus:3042663099
ISSN
1538-7445
language
English
LU publication?
yes
id
55c43016-02c3-41a6-8585-8bbc1ada8050 (old id 275702)
alternative location
http://cancerres.aacrjournals.org/cgi/content/abstract/64/12/4059
date added to LUP
2007-11-07 10:30:06
date last changed
2017-01-01 06:36:57
@article{55c43016-02c3-41a6-8585-8bbc1ada8050,
  abstract     = {Laminin-8 (alpha4beta1gamma1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin alpha4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The higher tumor growth rates in mutant mice correlate with decreased tumor cell apoptosis. Depletion of laminin alpha4 chain may alter the structure of vascular basement membranes, leading to increased angiogenesis. Our data suggest that the laminin-8 plays a critical role in the regulation of pathological angiogenesis.},
  author       = {Zhou, ZJ and Doi, M and Wang, JM and Cao, RH and Liu, BH and Chan, KM and Kortesmaa, J and Sorokin, Lydia and Cao, YH and Tryggvason, K},
  issn         = {1538-7445},
  language     = {eng},
  number       = {12},
  pages        = {4059--4063},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice},
  volume       = {64},
  year         = {2004},
}