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Vascular endothelial growth factor gene polymorphisms and pre-eclampsia

Papazoglou, D; Galazios, G; Koukourakis, MI; Panagopoulos, Ioannis LU ; Kontomanolis, EN; Papatheodorou, K and Maltezos, E (2004) In Molecular Human Reproduction 10(5). p.321-324
Abstract
Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between... (More)
Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between women with severe pre-eclampsia and controls (odds ratio: 2.70; 95% confidence interval: 1.09-6.63; P = 0.019). VEGF gene polymorphisms studied are unlikely to be major predisposing factors for pre-eclampsia. The presence of the 936T allele probably has a considerable effect on disease modification. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
vascular endothelial growth factor, pre-eclampsia, polymorphisms
in
Molecular Human Reproduction
volume
10
issue
5
pages
321 - 324
publisher
Oxford University Press
external identifiers
  • pmid:14997002
  • wos:000221821100004
  • scopus:2642542363
ISSN
1460-2407
DOI
10.1093/molehr/gah048
language
English
LU publication?
yes
id
d37c1511-2257-4e40-a09e-8b61a40cf93e (old id 276170)
date added to LUP
2007-10-29 14:15:32
date last changed
2017-10-01 03:51:28
@article{d37c1511-2257-4e40-a09e-8b61a40cf93e,
  abstract     = {Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the -2578C/A, -634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between women with severe pre-eclampsia and controls (odds ratio: 2.70; 95% confidence interval: 1.09-6.63; P = 0.019). VEGF gene polymorphisms studied are unlikely to be major predisposing factors for pre-eclampsia. The presence of the 936T allele probably has a considerable effect on disease modification.},
  author       = {Papazoglou, D and Galazios, G and Koukourakis, MI and Panagopoulos, Ioannis and Kontomanolis, EN and Papatheodorou, K and Maltezos, E},
  issn         = {1460-2407},
  keyword      = {vascular endothelial growth factor,pre-eclampsia,polymorphisms},
  language     = {eng},
  number       = {5},
  pages        = {321--324},
  publisher    = {Oxford University Press},
  series       = {Molecular Human Reproduction},
  title        = {Vascular endothelial growth factor gene polymorphisms and pre-eclampsia},
  url          = {http://dx.doi.org/10.1093/molehr/gah048},
  volume       = {10},
  year         = {2004},
}