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Negative neurofilament light and tau immunostaining in frontotemporal dementia

Sjogren, M and Englund, Elisabet LU (2004) Frontotemporal Dementias. 4th International Conference In Frontotemporal Dementias 4th International Conference (Dementia and Geriatric Cognitive Disorders) 17(4). p.346-349
Abstract
We investigated the immunohistochemical stainability of phosphorylated tau and the light (NFL), intermediate (NFM), and heavy (NFH) neurofilament proteins in postmortem brain tissue from 8 patients with frontotemporal dementia (FTD), for comparison with 6 patients with Alzheimer's disease (AD), and 6 normal controls. In the FTD group, the neuropathological diagnosis was pure frontal-lobe degeneration of non-Alzheimer type (FLD) in 6 cases and in the remaining 2 cases mixed FLD-AD and frontal AD, respectively. The staining for tau was negative in 5 of the FLD cases and faintly positive in 1, but positive in all AD cases. The antibodies against NFM and NFH stained positive in FLD, AD, and controls, whereas the staining for NFL was negative... (More)
We investigated the immunohistochemical stainability of phosphorylated tau and the light (NFL), intermediate (NFM), and heavy (NFH) neurofilament proteins in postmortem brain tissue from 8 patients with frontotemporal dementia (FTD), for comparison with 6 patients with Alzheimer's disease (AD), and 6 normal controls. In the FTD group, the neuropathological diagnosis was pure frontal-lobe degeneration of non-Alzheimer type (FLD) in 6 cases and in the remaining 2 cases mixed FLD-AD and frontal AD, respectively. The staining for tau was negative in 5 of the FLD cases and faintly positive in 1, but positive in all AD cases. The antibodies against NFM and NFH stained positive in FLD, AD, and controls, whereas the staining for NFL was negative in all FLD cases and positive in 1 AD case and in the controls. These findings regarding NFL and tau staining may be useful in the differential diagnosis of FLD and AD. Copyright (C) 2004 S. Karger AG, Basel. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Alzheimer's disease, frontotemporal dementia, immunohistochemical, staining, neurofilament light protein, tau protein
in
Frontotemporal Dementias 4th International Conference (Dementia and Geriatric Cognitive Disorders)
volume
17
issue
4
pages
346 - 349
publisher
Karger
conference name
Frontotemporal Dementias. 4th International Conference
external identifiers
  • wos:000221793000023
  • scopus:2642537533
ISSN
1421-9824
1420-8008
DOI
10.1159/000077169
language
English
LU publication?
yes
id
c380d584-a1e7-4f8e-b3aa-041a1052b343 (old id 276686)
date added to LUP
2007-10-31 16:20:19
date last changed
2017-01-01 04:41:14
@inproceedings{c380d584-a1e7-4f8e-b3aa-041a1052b343,
  abstract     = {We investigated the immunohistochemical stainability of phosphorylated tau and the light (NFL), intermediate (NFM), and heavy (NFH) neurofilament proteins in postmortem brain tissue from 8 patients with frontotemporal dementia (FTD), for comparison with 6 patients with Alzheimer's disease (AD), and 6 normal controls. In the FTD group, the neuropathological diagnosis was pure frontal-lobe degeneration of non-Alzheimer type (FLD) in 6 cases and in the remaining 2 cases mixed FLD-AD and frontal AD, respectively. The staining for tau was negative in 5 of the FLD cases and faintly positive in 1, but positive in all AD cases. The antibodies against NFM and NFH stained positive in FLD, AD, and controls, whereas the staining for NFL was negative in all FLD cases and positive in 1 AD case and in the controls. These findings regarding NFL and tau staining may be useful in the differential diagnosis of FLD and AD. Copyright (C) 2004 S. Karger AG, Basel.},
  author       = {Sjogren, M and Englund, Elisabet},
  booktitle    = {Frontotemporal Dementias 4th International Conference (Dementia and Geriatric Cognitive Disorders)},
  issn         = {1421-9824},
  keyword      = {Alzheimer's disease,frontotemporal dementia,immunohistochemical,staining,neurofilament light protein,tau protein},
  language     = {eng},
  number       = {4},
  pages        = {346--349},
  publisher    = {Karger},
  title        = {Negative neurofilament light and tau immunostaining in frontotemporal dementia},
  url          = {http://dx.doi.org/10.1159/000077169},
  volume       = {17},
  year         = {2004},
}