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Helicobacter pylori infection in children in Estonia: Decreasing seroprevalence during the 11-year period of profound socioeconomic changes

Oona, M; Utt, M; Nilsson, Ingrid LU ; Uibo, O; Vorobjova, T and Maaroos, HI (2004) In Helicobacter 9(3). p.233-241
Abstract
Background. The prevalence of Helicobacter pylori infection is inversely associated with socioeconomic conditions in childhood. In Estonia, a high prevalence of H. pylori infection has been observed among children born in 1987 and earlier. Since 1991, after the dissolution of the USSR, profound social and economic changes have taken place in the country. The aim of the study was to evaluate changes in the seroprevalence of H. pylori infection among children in the period 1991-2002. Materials and Methods. The hospital-based study population consisted of two groups of children enrolled in 1991 (n = 425) and 2002 (n = 296) according to the same inclusion criteria. The immunoglobulin G antibodies to the cell surface proteins of H. pylori were... (More)
Background. The prevalence of Helicobacter pylori infection is inversely associated with socioeconomic conditions in childhood. In Estonia, a high prevalence of H. pylori infection has been observed among children born in 1987 and earlier. Since 1991, after the dissolution of the USSR, profound social and economic changes have taken place in the country. The aim of the study was to evaluate changes in the seroprevalence of H. pylori infection among children in the period 1991-2002. Materials and Methods. The hospital-based study population consisted of two groups of children enrolled in 1991 (n = 425) and 2002 (n = 296) according to the same inclusion criteria. The immunoglobulin G antibodies to the cell surface proteins of H. pylori were determined by enzyme-linked immunosorbent assay, and the sera with the borderline results were analyzed by immunoblot analysis. Multiple regression analysis was used to determine the associations between H. pylori seropositivity and different variables such as demographic characteristics, diagnoses and year of enrolment. Results. The only two variables linked independently to H. pylori serostatus were age and year of enrolment: the adjusted odds of being H. pylori seropositive were 1.92 [95% confidence interval (CI) 1.33-2.76] times higher for the children enrolled in 1991 compared with the children enrolled in 2002. The age-standardized seroprevalence rate was 42.2% (95% CI 37.4-47.0%) for the group of 1991 and 28.1% (95% CI 23.1-33.6%) for the group of 2002. Conclusion. The prevalence of H. pylori infection among children has significantly decreased during the 11-year period of profound socioeconomic changes in Estonia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Helicobacter pylori, epidemiology, children and birth cohort effect
in
Helicobacter
volume
9
issue
3
pages
233 - 241
publisher
Wiley-Blackwell
external identifiers
  • pmid:15165259
  • wos:000221766700007
  • scopus:2642550160
ISSN
1083-4389
DOI
10.1111/j.1083-4389.2004.00229.x
language
English
LU publication?
yes
id
e9c5ad3d-1901-42ef-b97f-0c1af78e365f (old id 277000)
date added to LUP
2007-10-29 12:09:01
date last changed
2017-11-12 03:29:43
@article{e9c5ad3d-1901-42ef-b97f-0c1af78e365f,
  abstract     = {Background. The prevalence of Helicobacter pylori infection is inversely associated with socioeconomic conditions in childhood. In Estonia, a high prevalence of H. pylori infection has been observed among children born in 1987 and earlier. Since 1991, after the dissolution of the USSR, profound social and economic changes have taken place in the country. The aim of the study was to evaluate changes in the seroprevalence of H. pylori infection among children in the period 1991-2002. Materials and Methods. The hospital-based study population consisted of two groups of children enrolled in 1991 (n = 425) and 2002 (n = 296) according to the same inclusion criteria. The immunoglobulin G antibodies to the cell surface proteins of H. pylori were determined by enzyme-linked immunosorbent assay, and the sera with the borderline results were analyzed by immunoblot analysis. Multiple regression analysis was used to determine the associations between H. pylori seropositivity and different variables such as demographic characteristics, diagnoses and year of enrolment. Results. The only two variables linked independently to H. pylori serostatus were age and year of enrolment: the adjusted odds of being H. pylori seropositive were 1.92 [95% confidence interval (CI) 1.33-2.76] times higher for the children enrolled in 1991 compared with the children enrolled in 2002. The age-standardized seroprevalence rate was 42.2% (95% CI 37.4-47.0%) for the group of 1991 and 28.1% (95% CI 23.1-33.6%) for the group of 2002. Conclusion. The prevalence of H. pylori infection among children has significantly decreased during the 11-year period of profound socioeconomic changes in Estonia.},
  author       = {Oona, M and Utt, M and Nilsson, Ingrid and Uibo, O and Vorobjova, T and Maaroos, HI},
  issn         = {1083-4389},
  keyword      = {Helicobacter pylori,epidemiology,children and birth cohort effect},
  language     = {eng},
  number       = {3},
  pages        = {233--241},
  publisher    = {Wiley-Blackwell},
  series       = {Helicobacter},
  title        = {Helicobacter pylori infection in children in Estonia: Decreasing seroprevalence during the 11-year period of profound socioeconomic changes},
  url          = {http://dx.doi.org/10.1111/j.1083-4389.2004.00229.x},
  volume       = {9},
  year         = {2004},
}