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A novel pattern of pp65-positive cytomegalic endothelial cells circulating in peripheral blood from a renal transplant recipient

Ye, Q; Luo, GH; He, XZ; Zheng, L; Dong, X; Xu, XL; Gao, JS; Nilsson-Ehle, Peter LU and Xu, Ning LU (2004) In Acta Histochemica 106(2). p.107-110
Abstract
The present study reports a novel pattern of cytomegalic endothelial cells (CEC) in peripheral blood from a female renal transplant recipient infected with human cytomegalovirus (HCMV), which has not been reported previously. Localization of specific early antigen of HCMV, pp65 antigen, was examined by immunohistochemistry. Staining of an endothelial cell marker (CD34) was used to characterize endothelial cells. It is demonstrated that many leukocytes surrounded and adhered to a protein-like material, in which pp65-positive CEC were detected. The composition and function of this protein-like material are yet unknown. The patient tacked clinical symptoms of HCMV disease. Furthermore, similar localization patterns were found in other renal.... (More)
The present study reports a novel pattern of cytomegalic endothelial cells (CEC) in peripheral blood from a female renal transplant recipient infected with human cytomegalovirus (HCMV), which has not been reported previously. Localization of specific early antigen of HCMV, pp65 antigen, was examined by immunohistochemistry. Staining of an endothelial cell marker (CD34) was used to characterize endothelial cells. It is demonstrated that many leukocytes surrounded and adhered to a protein-like material, in which pp65-positive CEC were detected. The composition and function of this protein-like material are yet unknown. The patient tacked clinical symptoms of HCMV disease. Furthermore, similar localization patterns were found in other renal. transplant recipients suffering from HCMV infections as determined by real-time PCR to detect HCMV DNA in blood. These patients showed no or only minor clinical symptoms of HCMV infection. It is suggested that these novel Localization patterns of CEC may play a role in the host defense in patients infected with HCMV, but the exact relation between HCMV infection and CEC formation needs further investigation. (C) 2004 Elsevier GmbH. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
immunohistochemistry, human cytomegato-virus, cytomegatic endothelial cells, kidney transplantation
in
Acta Histochemica
volume
106
issue
2
pages
107 - 110
publisher
Elsevier
external identifiers
  • wos:000221541800004
  • pmid:15147631
  • scopus:4544237354
ISSN
0065-1281
DOI
10.1016/j.acthis.2004.01.003
language
English
LU publication?
yes
id
1f8250f6-2a4e-4bb8-be2c-d74735ad822c (old id 277438)
date added to LUP
2007-11-07 08:16:10
date last changed
2017-01-01 04:51:22
@article{1f8250f6-2a4e-4bb8-be2c-d74735ad822c,
  abstract     = {The present study reports a novel pattern of cytomegalic endothelial cells (CEC) in peripheral blood from a female renal transplant recipient infected with human cytomegalovirus (HCMV), which has not been reported previously. Localization of specific early antigen of HCMV, pp65 antigen, was examined by immunohistochemistry. Staining of an endothelial cell marker (CD34) was used to characterize endothelial cells. It is demonstrated that many leukocytes surrounded and adhered to a protein-like material, in which pp65-positive CEC were detected. The composition and function of this protein-like material are yet unknown. The patient tacked clinical symptoms of HCMV disease. Furthermore, similar localization patterns were found in other renal. transplant recipients suffering from HCMV infections as determined by real-time PCR to detect HCMV DNA in blood. These patients showed no or only minor clinical symptoms of HCMV infection. It is suggested that these novel Localization patterns of CEC may play a role in the host defense in patients infected with HCMV, but the exact relation between HCMV infection and CEC formation needs further investigation. (C) 2004 Elsevier GmbH. All rights reserved.},
  author       = {Ye, Q and Luo, GH and He, XZ and Zheng, L and Dong, X and Xu, XL and Gao, JS and Nilsson-Ehle, Peter and Xu, Ning},
  issn         = {0065-1281},
  keyword      = {immunohistochemistry,human cytomegato-virus,cytomegatic endothelial cells,kidney transplantation},
  language     = {eng},
  number       = {2},
  pages        = {107--110},
  publisher    = {Elsevier},
  series       = {Acta Histochemica},
  title        = {A novel pattern of pp65-positive cytomegalic endothelial cells circulating in peripheral blood from a renal transplant recipient},
  url          = {http://dx.doi.org/10.1016/j.acthis.2004.01.003},
  volume       = {106},
  year         = {2004},
}