Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Serum sialic acid and sialoglycoproteins in asymptomatic carotid artery atherosclerosis. ARIC Investigators. Atherosclerosis Risk in Communities

Lindberg, Gunnar LU ; Råstam, Lennart LU ; Nilsson-Ehle, Peter LU ; Lundblad, A ; Ranstam, Jonas LU ; Folsom, A R and Burke, G L (1999) In Atherosclerosis 146(1). p.65-69
Abstract
Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and alpha1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P<0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as... (More)
Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and alpha1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P<0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as independent variables, orosomucoid was correlated most strongly with case control status. However, when incorporated into the mathematical model, S-TSA not only contributed additional information as to the risk of atherosclerosis; none of the three glycoproteins contributed further once S-TSA had been accounted for. Thus, some other source of serum sialic acid or variations in the degree of sialylation of glycoproteins may be essential for understanding the relation between S-TSA and atherosclerosis. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Carotid atherosclerosis, Sialic acids, Orosomucoid, Haptoglobin, greek small letter alpha1-Antitrypsin, Human, Cross-sectional study
in
Atherosclerosis
volume
146
issue
1
pages
65 - 69
publisher
Elsevier
external identifiers
  • pmid:10487488
  • scopus:0344500690
ISSN
1879-1484
DOI
10.1016/S0021-9150(99)00130-6
language
English
LU publication?
yes
id
27817129-eac5-4710-864f-5d9f3d370a59 (old id 1115761)
date added to LUP
2016-04-01 12:31:49
date last changed
2022-01-27 06:21:55
@article{27817129-eac5-4710-864f-5d9f3d370a59,
  abstract     = {{Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and alpha1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P&lt;0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as independent variables, orosomucoid was correlated most strongly with case control status. However, when incorporated into the mathematical model, S-TSA not only contributed additional information as to the risk of atherosclerosis; none of the three glycoproteins contributed further once S-TSA had been accounted for. Thus, some other source of serum sialic acid or variations in the degree of sialylation of glycoproteins may be essential for understanding the relation between S-TSA and atherosclerosis.}},
  author       = {{Lindberg, Gunnar and Råstam, Lennart and Nilsson-Ehle, Peter and Lundblad, A and Ranstam, Jonas and Folsom, A R and Burke, G L}},
  issn         = {{1879-1484}},
  keywords     = {{Carotid atherosclerosis; Sialic acids; Orosomucoid; Haptoglobin; greek small letter alpha1-Antitrypsin; Human; Cross-sectional study}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{65--69}},
  publisher    = {{Elsevier}},
  series       = {{Atherosclerosis}},
  title        = {{Serum sialic acid and sialoglycoproteins in asymptomatic carotid artery atherosclerosis. ARIC Investigators. Atherosclerosis Risk in Communities}},
  url          = {{http://dx.doi.org/10.1016/S0021-9150(99)00130-6}},
  doi          = {{10.1016/S0021-9150(99)00130-6}},
  volume       = {{146}},
  year         = {{1999}},
}