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Association of HLA-DQ5 and HLA-DR1 with sensitization to organic acidanhydrides

Jones, MG; Nielsen, Jörn LU ; Welch, J; Harris, J; Welinder, Hans LU ; Bensryd, Inger LU ; Skerfving, Staffan LU ; Welsh, K; Venables, KM and Taylor, AN (2004) In Clinical and Experimental Allergy 34(5). p.812-816
Abstract
Background Organic acid anhydrides are low molecular weight industrial chemicals, able to cause rhinoconjunctivitis and asthma associated with specific IgE against hapten-carrier protein conjugate. Only a proportion of exposed workers develop IgE-associated allergy to acid anhydrides. Objective We determined whether genetic susceptibility, in particular, HLA Class II alleles may be a risk factor. Methods We undertook HLA typing in 52 cases who had confirmed specific IgE and in 73 referents matched on site, age and duration of acid anhydride exposure identified in cross-sectional studies of workers exposed to hexahydrophthalic (HHPA), methylhexahydrophthalic (MHHPA) and methyltetrahydrophthalic (MTHPA) anhydrides. Results The linked alleles... (More)
Background Organic acid anhydrides are low molecular weight industrial chemicals, able to cause rhinoconjunctivitis and asthma associated with specific IgE against hapten-carrier protein conjugate. Only a proportion of exposed workers develop IgE-associated allergy to acid anhydrides. Objective We determined whether genetic susceptibility, in particular, HLA Class II alleles may be a risk factor. Methods We undertook HLA typing in 52 cases who had confirmed specific IgE and in 73 referents matched on site, age and duration of acid anhydride exposure identified in cross-sectional studies of workers exposed to hexahydrophthalic (HHPA), methylhexahydrophthalic (MHHPA) and methyltetrahydrophthalic (MTHPA) anhydrides. Results The linked alleles DQ5 (odds ratio [OR]=4.3; 95% confidence interval [95% CI]=1.7, 11) and DR1 (OR 3.0; 95% CI 1.2, 11) were more prevalent in cases than in referents. Within DQ5, DQB1*0501 was particularly frequent (OR 3.0; 95% CI 1.2, 7.4). Conclusion DQB1*05 gene confers susceptibility to develop specific IgE antibodies against HHPA, MHHPA and a non-significant trend with MTHPA. DQB1*0501 is protective for other low molecular chemical sensitizers (isocyanates and plicatic acid) which may indicate varying affinities for the corresponding specific class II molecules. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
occupational allergy and asthma, acid anhydrides, HLA class II
in
Clinical and Experimental Allergy
volume
34
issue
5
pages
812 - 816
publisher
Wiley-Blackwell
external identifiers
  • wos:000221401900023
  • pmid:15144476
  • scopus:2942612675
ISSN
1365-2222
DOI
10.1111/j.1365-2222.2004.1956.x
language
English
LU publication?
yes
id
3ab60119-adf9-4c06-ba36-3a922166d0b3 (old id 279107)
date added to LUP
2007-08-02 16:06:51
date last changed
2017-01-29 03:25:25
@article{3ab60119-adf9-4c06-ba36-3a922166d0b3,
  abstract     = {Background Organic acid anhydrides are low molecular weight industrial chemicals, able to cause rhinoconjunctivitis and asthma associated with specific IgE against hapten-carrier protein conjugate. Only a proportion of exposed workers develop IgE-associated allergy to acid anhydrides. Objective We determined whether genetic susceptibility, in particular, HLA Class II alleles may be a risk factor. Methods We undertook HLA typing in 52 cases who had confirmed specific IgE and in 73 referents matched on site, age and duration of acid anhydride exposure identified in cross-sectional studies of workers exposed to hexahydrophthalic (HHPA), methylhexahydrophthalic (MHHPA) and methyltetrahydrophthalic (MTHPA) anhydrides. Results The linked alleles DQ5 (odds ratio [OR]=4.3; 95% confidence interval [95% CI]=1.7, 11) and DR1 (OR 3.0; 95% CI 1.2, 11) were more prevalent in cases than in referents. Within DQ5, DQB1*0501 was particularly frequent (OR 3.0; 95% CI 1.2, 7.4). Conclusion DQB1*05 gene confers susceptibility to develop specific IgE antibodies against HHPA, MHHPA and a non-significant trend with MTHPA. DQB1*0501 is protective for other low molecular chemical sensitizers (isocyanates and plicatic acid) which may indicate varying affinities for the corresponding specific class II molecules.},
  author       = {Jones, MG and Nielsen, Jörn and Welch, J and Harris, J and Welinder, Hans and Bensryd, Inger and Skerfving, Staffan and Welsh, K and Venables, KM and Taylor, AN},
  issn         = {1365-2222},
  keyword      = {occupational allergy and asthma,acid anhydrides,HLA class II},
  language     = {eng},
  number       = {5},
  pages        = {812--816},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical and Experimental Allergy},
  title        = {Association of HLA-DQ5 and HLA-DR1 with sensitization to organic acidanhydrides},
  url          = {http://dx.doi.org/10.1111/j.1365-2222.2004.1956.x},
  volume       = {34},
  year         = {2004},
}