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Obstetric adversity and age at first presentation with schizophrenia: Evidence of a dose-response relationship

Kelly, BD; Feeney, L; O'Callaghan, E; Browne, R; Byrne, M; Mulryan, N; Scully, A; Morris, M; Kinsella, A and Takei, N, et al. (2004) In American Journal of Psychiatry 161(5). p.920-922
Abstract
Objective: The purpose of the study was to determine if a dose-response relationship exists between obstetric adversity and age at first presentation with schizophrenia. Method: The Dublin Psychiatric Case Register was used to identify subjects with schizophrenia. Data on obstetric complications, social class of origin, and family history of psychiatric illness were obtained for those subjects. Results: A total of 409 patients with ICD-9 schizophrenia were identified. Patients with a history of obstetric complications presented earlier to psychiatric services. As the number of complications increased, the mean age at first presentation decreased. This effect was independent of social class of origin and family history of psychiatric... (More)
Objective: The purpose of the study was to determine if a dose-response relationship exists between obstetric adversity and age at first presentation with schizophrenia. Method: The Dublin Psychiatric Case Register was used to identify subjects with schizophrenia. Data on obstetric complications, social class of origin, and family history of psychiatric illness were obtained for those subjects. Results: A total of 409 patients with ICD-9 schizophrenia were identified. Patients with a history of obstetric complications presented earlier to psychiatric services. As the number of complications increased, the mean age at first presentation decreased. This effect was independent of social class of origin and family history of psychiatric illness. Conclusions: Obstetric adversity exerts an independent influence on the age at first presentation with schizophrenia, in a dose-response manner. This finding supports the existence of a causal relationship between obstetric adversity and age at first presentation with schizophrenia. (Less)
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Contribution to journal
publication status
published
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in
American Journal of Psychiatry
volume
161
issue
5
pages
920 - 922
publisher
American Psychiatric Association
external identifiers
  • pmid:15121662
  • wos:000221361700023
  • scopus:2442480539
ISSN
1535-7228
language
English
LU publication?
yes
id
374372de-9f7e-4660-aafc-e9d62e955936 (old id 279223)
alternative location
http://ajp.psychiatryonline.org/cgi/content/abstract/161/5/920
date added to LUP
2007-10-23 18:12:14
date last changed
2017-01-01 04:34:50
@article{374372de-9f7e-4660-aafc-e9d62e955936,
  abstract     = {Objective: The purpose of the study was to determine if a dose-response relationship exists between obstetric adversity and age at first presentation with schizophrenia. Method: The Dublin Psychiatric Case Register was used to identify subjects with schizophrenia. Data on obstetric complications, social class of origin, and family history of psychiatric illness were obtained for those subjects. Results: A total of 409 patients with ICD-9 schizophrenia were identified. Patients with a history of obstetric complications presented earlier to psychiatric services. As the number of complications increased, the mean age at first presentation decreased. This effect was independent of social class of origin and family history of psychiatric illness. Conclusions: Obstetric adversity exerts an independent influence on the age at first presentation with schizophrenia, in a dose-response manner. This finding supports the existence of a causal relationship between obstetric adversity and age at first presentation with schizophrenia.},
  author       = {Kelly, BD and Feeney, L and O'Callaghan, E and Browne, R and Byrne, M and Mulryan, N and Scully, A and Morris, M and Kinsella, A and Takei, N and McNeil, Thomas and Walsh, D and Larkin, C},
  issn         = {1535-7228},
  language     = {eng},
  number       = {5},
  pages        = {920--922},
  publisher    = {American Psychiatric Association},
  series       = {American Journal of Psychiatry},
  title        = {Obstetric adversity and age at first presentation with schizophrenia: Evidence of a dose-response relationship},
  volume       = {161},
  year         = {2004},
}