Obstetric adversity and age at first presentation with schizophrenia: Evidence of a dose-response relationship
(2004) In American Journal of Psychiatry 161(5). p.920-922- Abstract
- Objective: The purpose of the study was to determine if a dose-response relationship exists between obstetric adversity and age at first presentation with schizophrenia. Method: The Dublin Psychiatric Case Register was used to identify subjects with schizophrenia. Data on obstetric complications, social class of origin, and family history of psychiatric illness were obtained for those subjects. Results: A total of 409 patients with ICD-9 schizophrenia were identified. Patients with a history of obstetric complications presented earlier to psychiatric services. As the number of complications increased, the mean age at first presentation decreased. This effect was independent of social class of origin and family history of psychiatric... (More)
- Objective: The purpose of the study was to determine if a dose-response relationship exists between obstetric adversity and age at first presentation with schizophrenia. Method: The Dublin Psychiatric Case Register was used to identify subjects with schizophrenia. Data on obstetric complications, social class of origin, and family history of psychiatric illness were obtained for those subjects. Results: A total of 409 patients with ICD-9 schizophrenia were identified. Patients with a history of obstetric complications presented earlier to psychiatric services. As the number of complications increased, the mean age at first presentation decreased. This effect was independent of social class of origin and family history of psychiatric illness. Conclusions: Obstetric adversity exerts an independent influence on the age at first presentation with schizophrenia, in a dose-response manner. This finding supports the existence of a causal relationship between obstetric adversity and age at first presentation with schizophrenia. (Less)
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https://lup.lub.lu.se/record/279223
- author
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Psychiatry
- volume
- 161
- issue
- 5
- pages
- 920 - 922
- publisher
- American Psychiatric Association
- external identifiers
-
- pmid:15121662
- wos:000221361700023
- scopus:2442480539
- ISSN
- 1535-7228
- language
- English
- LU publication?
- yes
- id
- 374372de-9f7e-4660-aafc-e9d62e955936 (old id 279223)
- alternative location
- http://ajp.psychiatryonline.org/cgi/content/abstract/161/5/920
- date added to LUP
- 2016-04-01 11:49:37
- date last changed
- 2022-01-26 18:52:21
@article{374372de-9f7e-4660-aafc-e9d62e955936, abstract = {{Objective: The purpose of the study was to determine if a dose-response relationship exists between obstetric adversity and age at first presentation with schizophrenia. Method: The Dublin Psychiatric Case Register was used to identify subjects with schizophrenia. Data on obstetric complications, social class of origin, and family history of psychiatric illness were obtained for those subjects. Results: A total of 409 patients with ICD-9 schizophrenia were identified. Patients with a history of obstetric complications presented earlier to psychiatric services. As the number of complications increased, the mean age at first presentation decreased. This effect was independent of social class of origin and family history of psychiatric illness. Conclusions: Obstetric adversity exerts an independent influence on the age at first presentation with schizophrenia, in a dose-response manner. This finding supports the existence of a causal relationship between obstetric adversity and age at first presentation with schizophrenia.}}, author = {{Kelly, BD and Feeney, L and O'Callaghan, E and Browne, R and Byrne, M and Mulryan, N and Scully, A and Morris, M and Kinsella, A and Takei, N and McNeil, Thomas and Walsh, D and Larkin, C}}, issn = {{1535-7228}}, language = {{eng}}, number = {{5}}, pages = {{920--922}}, publisher = {{American Psychiatric Association}}, series = {{American Journal of Psychiatry}}, title = {{Obstetric adversity and age at first presentation with schizophrenia: Evidence of a dose-response relationship}}, url = {{http://ajp.psychiatryonline.org/cgi/content/abstract/161/5/920}}, volume = {{161}}, year = {{2004}}, }