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Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

Smits, KM; Benhamou, S; Garte, S; Weijenberg, MP; Alamanos, Y; Ambrosone, C; Autrup, H; Autrup, JL; Baranova, H and Bathum, L, et al. (2004) In International Journal of Cancer 110(2). p.266-270
Abstract
Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient... (More)
Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYPIAI, GSTMI, GSTTI, NAT2 and GSTPI. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected. (Less)
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publishing date
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Contribution to journal
publication status
published
subject
keywords
pooled analysis, molecular epidemiology, smoking
in
International Journal of Cancer
volume
110
issue
2
pages
266 - 270
publisher
John Wiley & Sons
external identifiers
  • pmid:15069692
  • wos:000221181500017
  • scopus:2342612759
ISSN
0020-7136
DOI
10.1002/ijc.20114
language
English
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yes
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4727cd56-6f06-4e40-b26f-063f4619983e (old id 279780)
date added to LUP
2007-10-26 14:25:58
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2017-01-29 03:24:05
@article{4727cd56-6f06-4e40-b26f-063f4619983e,
  abstract     = {Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYPIAI, GSTMI, GSTTI, NAT2 and GSTPI. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.},
  author       = {Smits, KM and Benhamou, S and Garte, S and Weijenberg, MP and Alamanos, Y and Ambrosone, C and Autrup, H and Autrup, JL and Baranova, H and Bathum, L and Boffetta, P and Bouchardy, C and Brockmoller, J and Butkiewicz, D and Cascorbi, I and Clapper, ML and Coutelle, C and Daly, AK and Muzi, G and Dolzan, V and Duzhak, TG and Farker, K and Golka, K and Haugen, A and Hein, DW and Hildesheim, A and Hirvonen, A and Hsieh, LL and Ingelman-Sundberg, M and Kalina, I and Kang, D and Katoh, T and Kihara, M and Ono-Kihara, M and Kim, H and Kiyohara, C and Kremers, P and Lazarus, P and Le Marchand, L and Lechner, MC and London, S and Manni, JJ and Maugard, CM and Morgan, GJ and Morita, S and Nazar-Stewart, V and Kristensen, VN and Oda, Y and Parl, FF and Peters, WHM and Rannug, A and Rebbeck, T and Pinto, LFR and Risch, A and Romkes, M and Salagovic, J and Schoket, B and SeidegÄrd, Janeric and Shields, PG and Sim, E and Sinnett, D and Strange, RC and Stucker, I and Sugimura, H and To-Figueras, J and Vineis, P and Yu, MC and Zheng, W and Pedotti, P and Taioli, E},
  issn         = {0020-7136},
  keyword      = {pooled analysis,molecular epidemiology,smoking},
  language     = {eng},
  number       = {2},
  pages        = {266--270},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Association of metabolic gene polymorphisms with tobacco consumption in healthy controls},
  url          = {http://dx.doi.org/10.1002/ijc.20114},
  volume       = {110},
  year         = {2004},
}