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Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes

Scholin, A; Törn, Carina LU ; Nystrom, L; Berne, C; Arnqvist, H; Blohme, G; Bolinder, J; Eriksson, JW; Kockum, I and Landin-Olsson, Mona LU , et al. (2004) In Diabetic Medicine 21(5). p.447-455
Abstract
Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM). Methods In Sweden 362 patients (15-34 years) classified as Type 1 DM were,, included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA(1c) and insulin dosage over a median period after diagnosis of 5 years. Duration of remission defined, as an insulin maintenance dose less than or equal to 0.3 U/kg/24 h and HbA(1c) within the normal range, was analysed in relation to characteristics at diagnosis. Results Remissions were seen in 43% of the patients with a median duration of 8 months (range 1-73).... (More)
Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM). Methods In Sweden 362 patients (15-34 years) classified as Type 1 DM were,, included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA(1c) and insulin dosage over a median period after diagnosis of 5 years. Duration of remission defined, as an insulin maintenance dose less than or equal to 0.3 U/kg/24 h and HbA(1c) within the normal range, was analysed in relation to characteristics at diagnosis. Results Remissions were seen in 43% of the patients with a median duration of 8 months (range 1-73). Sixteen per cent had a remission with a duration > 12 months. Among patients with antibodies (ab(+)), bivariate analysis suggested that adult age, absence of low BMI, high plasma C-peptide concentrations, lack of ketonuria or ketoacidosis at diagnosis and low insulin dose at discharge from hospital were associated with a high possibility of achieving remission. Multiple regression showed that normal weight (BMI of 20-24.9 kg/m(2)) was the only factor that remained significant for the possibility of entering remission. In survival analysis among ab(+) remitters, a low number of islet antibodies, one or two instead of three or four, were associated with a long duration of remissions. Conclusion In islet antibody-positive Type 1 DM, normal body weight was the strongest factor for entering remission, whilst a low number of islet antibodies was of importance for the duration. (Less)
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Contribution to journal
publication status
published
subject
keywords
Type 1 DM, remission, BMI, islet antibodies, young adults
in
Diabetic Medicine
volume
21
issue
5
pages
447 - 455
publisher
Wiley-Blackwell
external identifiers
  • wos:000221243700007
  • scopus:2342482358
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2004.01175.x
language
English
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yes
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e862edb3-327a-4e12-bbe0-4eac4d14f0aa (old id 279885)
date added to LUP
2007-10-26 13:28:43
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2017-11-19 04:11:16
@article{e862edb3-327a-4e12-bbe0-4eac4d14f0aa,
  abstract     = {Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM). Methods In Sweden 362 patients (15-34 years) classified as Type 1 DM were,, included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA(1c) and insulin dosage over a median period after diagnosis of 5 years. Duration of remission defined, as an insulin maintenance dose less than or equal to 0.3 U/kg/24 h and HbA(1c) within the normal range, was analysed in relation to characteristics at diagnosis. Results Remissions were seen in 43% of the patients with a median duration of 8 months (range 1-73). Sixteen per cent had a remission with a duration > 12 months. Among patients with antibodies (ab(+)), bivariate analysis suggested that adult age, absence of low BMI, high plasma C-peptide concentrations, lack of ketonuria or ketoacidosis at diagnosis and low insulin dose at discharge from hospital were associated with a high possibility of achieving remission. Multiple regression showed that normal weight (BMI of 20-24.9 kg/m(2)) was the only factor that remained significant for the possibility of entering remission. In survival analysis among ab(+) remitters, a low number of islet antibodies, one or two instead of three or four, were associated with a long duration of remissions. Conclusion In islet antibody-positive Type 1 DM, normal body weight was the strongest factor for entering remission, whilst a low number of islet antibodies was of importance for the duration.},
  author       = {Scholin, A and Törn, Carina and Nystrom, L and Berne, C and Arnqvist, H and Blohme, G and Bolinder, J and Eriksson, JW and Kockum, I and Landin-Olsson, Mona and Ostman, J and Karlsson, FA and Sundkvist, Göran and Bjork, E},
  issn         = {1464-5491},
  keyword      = {Type 1 DM,remission,BMI,islet antibodies,young adults},
  language     = {eng},
  number       = {5},
  pages        = {447--455},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic Medicine},
  title        = {Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes},
  url          = {http://dx.doi.org/10.1111/j.1464-5491.2004.01175.x},
  volume       = {21},
  year         = {2004},
}