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Heme A biosynthesis

Hederstedt, Lars LU (2012) In Biochimica et Biophysica Acta - Bioenergetics 1817(6). p.920-927
Abstract
Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side group at position C8 of the porphyrin macrocycle. Heme A synthase catalyzes the formation of the formyl side group and is a poorly understood heme-containing membrane bound atypical monooxygenase. This review presents our current understanding of heme A synthesis at the molecular level in mitochondria and aerobic bacteria. This article is part of a... (More)
Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side group at position C8 of the porphyrin macrocycle. Heme A synthase catalyzes the formation of the formyl side group and is a poorly understood heme-containing membrane bound atypical monooxygenase. This review presents our current understanding of heme A synthesis at the molecular level in mitochondria and aerobic bacteria. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. (C) 2012 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cytochrome biogenesis, Heme synthesis, CtaA, COX15, Oxidase assembly
in
Biochimica et Biophysica Acta - Bioenergetics
volume
1817
issue
6
pages
920 - 927
publisher
Elsevier
external identifiers
  • wos:000304504200008
  • scopus:84860663812
ISSN
0005-2728
DOI
10.1016/j.bbabio.2012.03.025http://dx.doi.org/10.1016/j.bbabio.2012.03.025
language
English
LU publication?
yes
id
e54411c6-170a-4a16-a24d-1325f7dcba6f (old id 2799645)
date added to LUP
2012-07-03 10:24:56
date last changed
2017-10-01 04:20:36
@article{e54411c6-170a-4a16-a24d-1325f7dcba6f,
  abstract     = {Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side group at position C8 of the porphyrin macrocycle. Heme A synthase catalyzes the formation of the formyl side group and is a poorly understood heme-containing membrane bound atypical monooxygenase. This review presents our current understanding of heme A synthesis at the molecular level in mitochondria and aerobic bacteria. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. (C) 2012 Elsevier B.V. All rights reserved.},
  author       = {Hederstedt, Lars},
  issn         = {0005-2728},
  keyword      = {Cytochrome biogenesis,Heme synthesis,CtaA,COX15,Oxidase assembly},
  language     = {eng},
  number       = {6},
  pages        = {920--927},
  publisher    = {Elsevier},
  series       = {Biochimica et Biophysica Acta - Bioenergetics},
  title        = {Heme A biosynthesis},
  url          = {http://dx.doi.org/10.1016/j.bbabio.2012.03.025http://dx.doi.org/10.1016/j.bbabio.2012.03.025},
  volume       = {1817},
  year         = {2012},
}