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Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time

Reiling, Erwin; Lyssenko, Valeriya LU ; Boer, Jolanda M. A.; Imholz, Sandra; Verschuren, W. Monique M.; Isomaa, Bo; Tuomi, Tiinamaija; Groop, Leif LU and Dolle, Martijn E. T. (2012) In European Journal of Human Genetics 20(6). p.696-700
Abstract
p53 is involved in stress response, metabolism and cardiovascular functioning. The C-allele of rs1042522 in the gene encoding for p53 is associated with longevity and cancer. In this study, we aimed to investigate the association of rs1042522 with changes in blood pressure, BMI and waist circumference using a longitudinal approach. Rs1042522 was analyzed in two longitudinal studies; the Doetinchem Cohort Study (DCS) and the Botnia Prospective Study (BPS). Changes in quantitative traits over time were investigated according to rs1042522 genotypes. An association between rs1042522 and changes in diastolic blood pressure (DBP) in the DCS over time was observed (P=0.004). Furthermore, a borderline significant association was detected with... (More)
p53 is involved in stress response, metabolism and cardiovascular functioning. The C-allele of rs1042522 in the gene encoding for p53 is associated with longevity and cancer. In this study, we aimed to investigate the association of rs1042522 with changes in blood pressure, BMI and waist circumference using a longitudinal approach. Rs1042522 was analyzed in two longitudinal studies; the Doetinchem Cohort Study (DCS) and the Botnia Prospective Study (BPS). Changes in quantitative traits over time were investigated according to rs1042522 genotypes. An association between rs1042522 and changes in diastolic blood pressure (DBP) in the DCS over time was observed (P=0.004). Furthermore, a borderline significant association was detected with changes in waist circumference over time (P=0.03). These findings were also observed in the BPS (P=0.02 and P=0.05). The C/C-genotype (Pro/Pro) showed the most moderate time-related increase for the studied endpoints. Furthermore, data from the BPS suggested that the C/C-genotype protects against increases in glucose levels over time at 30 and 60 min during oral glucose tolerance test (P=0.01 and P=0.02). In conclusion, we found an association between the C/C-genotype of rs1042522 and changes in DBP and waist circumference over time. This might contribute to the longevity phenotype observed for the same genotype by others. European Journal of Human Genetics (2012) 20, 696-700; doi:10.1038/ejhg.2011.240; published online 21 December 2011 (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
p53, blood pressure, metabolism, longitudinal study
in
European Journal of Human Genetics
volume
20
issue
6
pages
696 - 700
publisher
Nature Publishing Group
external identifiers
  • wos:000304200000020
  • scopus:84861190823
ISSN
1476-5438
DOI
10.1038/ejhg.2011.240
language
English
LU publication?
yes
id
17631e73-f634-4752-b928-c395ef5e6df0 (old id 2799674)
date added to LUP
2012-07-03 10:25:04
date last changed
2017-10-22 03:18:42
@article{17631e73-f634-4752-b928-c395ef5e6df0,
  abstract     = {p53 is involved in stress response, metabolism and cardiovascular functioning. The C-allele of rs1042522 in the gene encoding for p53 is associated with longevity and cancer. In this study, we aimed to investigate the association of rs1042522 with changes in blood pressure, BMI and waist circumference using a longitudinal approach. Rs1042522 was analyzed in two longitudinal studies; the Doetinchem Cohort Study (DCS) and the Botnia Prospective Study (BPS). Changes in quantitative traits over time were investigated according to rs1042522 genotypes. An association between rs1042522 and changes in diastolic blood pressure (DBP) in the DCS over time was observed (P=0.004). Furthermore, a borderline significant association was detected with changes in waist circumference over time (P=0.03). These findings were also observed in the BPS (P=0.02 and P=0.05). The C/C-genotype (Pro/Pro) showed the most moderate time-related increase for the studied endpoints. Furthermore, data from the BPS suggested that the C/C-genotype protects against increases in glucose levels over time at 30 and 60 min during oral glucose tolerance test (P=0.01 and P=0.02). In conclusion, we found an association between the C/C-genotype of rs1042522 and changes in DBP and waist circumference over time. This might contribute to the longevity phenotype observed for the same genotype by others. European Journal of Human Genetics (2012) 20, 696-700; doi:10.1038/ejhg.2011.240; published online 21 December 2011},
  author       = {Reiling, Erwin and Lyssenko, Valeriya and Boer, Jolanda M. A. and Imholz, Sandra and Verschuren, W. Monique M. and Isomaa, Bo and Tuomi, Tiinamaija and Groop, Leif and Dolle, Martijn E. T.},
  issn         = {1476-5438},
  keyword      = {p53,blood pressure,metabolism,longitudinal study},
  language     = {eng},
  number       = {6},
  pages        = {696--700},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Human Genetics},
  title        = {Codon 72 polymorphism (rs1042522) of TP53 is associated with changes in diastolic blood pressure over time},
  url          = {http://dx.doi.org/10.1038/ejhg.2011.240},
  volume       = {20},
  year         = {2012},
}