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Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.

Bhattachariya, Anirban LU ; Dahan, Diana LU ; Ekman, Mari LU ; Boettger, T ; Braun, T ; Swärd, Karl LU ; Hellstrand, Per LU and Albinsson, Sebastian LU (2015) In Acta Physiologica 215(3). p.133-143
Abstract
Stretch is essential for maintaining the contractile phenotype of vascular smooth muscle cells, and small non-coding microRNAs are known to be important in this process. Using a Dicer knockout model, we have previously reported that microRNAs are essential for stretch-induced differentiation and regulation of L-type calcium channel expression. The aim of this study was to investigate the importance of the smooth muscle-enriched miR-143/145 microRNA cluster for stretch-induced differentiation of the portal vein.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica
volume
215
issue
3
pages
133 - 143
publisher
Wiley-Blackwell
external identifiers
  • pmid:26052659
  • wos:000362894200006
  • scopus:84943579848
  • pmid:26052659
ISSN
1748-1716
DOI
10.1111/apha.12536
language
English
LU publication?
yes
id
27a985e4-3fd7-47df-8d32-295ed9c78d1a (old id 7487582)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26052659?dopt=Abstract
date added to LUP
2016-04-01 10:14:05
date last changed
2022-04-27 20:00:22
@article{27a985e4-3fd7-47df-8d32-295ed9c78d1a,
  abstract     = {{Stretch is essential for maintaining the contractile phenotype of vascular smooth muscle cells, and small non-coding microRNAs are known to be important in this process. Using a Dicer knockout model, we have previously reported that microRNAs are essential for stretch-induced differentiation and regulation of L-type calcium channel expression. The aim of this study was to investigate the importance of the smooth muscle-enriched miR-143/145 microRNA cluster for stretch-induced differentiation of the portal vein.}},
  author       = {{Bhattachariya, Anirban and Dahan, Diana and Ekman, Mari and Boettger, T and Braun, T and Swärd, Karl and Hellstrand, Per and Albinsson, Sebastian}},
  issn         = {{1748-1716}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{133--143}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Physiologica}},
  title        = {{Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.}},
  url          = {{https://lup.lub.lu.se/search/files/1675749/7852855.pdf}},
  doi          = {{10.1111/apha.12536}},
  volume       = {{215}},
  year         = {{2015}},
}