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Correlation of seismocardiography variables with echocardiographic and cardiac magnetic resonance measurements

Agam, Ahmad ; Korsgaard, Emil ; Kragholm, Kristian ; Kristensen, Charlotte Burup LU orcid ; Mogelvang, Rasmus ; Emerek, Kasper Janus Grønn ; Schmidt, Samuel Emil and Søgaard, Peter (2026) In Biomedical Physics and Engineering Express 12(4).
Abstract

Background. Seismocardiography (SCG) is a non-invasive, wearable technology that captures mechanical vibrations of the heart, offering a potential low-cost tool for assessing cardiac function. While conventional imaging modalities such as transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR) provide detailed structural and volumetric measures, they are operator-dependent and require specialized training. This study aimed to evaluate the correlation between SCG, TTE and CMR markers of systolic and diastolic function in healthy individuals and those with cardiovascular disease (CVD). Methods. Twenty-six subjects (age 45 ± 16 years and 77% male) were included, 10 healthy subjects and 16 subjects with CVD. All subjects... (More)

Background. Seismocardiography (SCG) is a non-invasive, wearable technology that captures mechanical vibrations of the heart, offering a potential low-cost tool for assessing cardiac function. While conventional imaging modalities such as transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR) provide detailed structural and volumetric measures, they are operator-dependent and require specialized training. This study aimed to evaluate the correlation between SCG, TTE and CMR markers of systolic and diastolic function in healthy individuals and those with cardiovascular disease (CVD). Methods. Twenty-six subjects (age 45 ± 16 years and 77% male) were included, 10 healthy subjects and 16 subjects with CVD. All subjects underwent SCG, TTE, and CMR measurements before and after intravenous infusion of 2.0 l isotonic saline. SCG signals were segmented into individual heartbeats, and fiducial points were automatically detected and manually validated. Results. SCG amplitudes Cd-to-Dd and Dd demonstrated moderate correlations with the diastolic parameter e′ from TTE (r = 0.42–0.66), while SCG time intervals Gs-Bd and Ls-Bd correlated moderately with LVET (r = 0.51–0.66). These associations were consistent across both healthy participants and patients with CVD. Conclusion. SCG-derived measures correlate moderately with TTE markers of diastolic (e′) and systolic (LVET) function, and these associations are preserved in both healthy and CVD subgroups, indicating robustness across clinical phenotypes. The findings in this study support SCG’s potential as a non-invasive tool for assessing mechanical cardiac function. However, further validation in real-world wearable settings is required.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiac function, cardiac magnetic resonance, correlation, diastolic, echocardiography, SCG, seismocardiogram, Seismocardiography, systolic
in
Biomedical Physics and Engineering Express
volume
12
issue
4
article number
045063
publisher
IOP Publishing
external identifiers
  • scopus:105046996006
  • pmid:42546748
ISSN
2057-1976
DOI
10.1088/2057-1976/ae93bc
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2026 The Author(s). Published by IOP Publishing Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 license. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
id
27cf02e4-f732-4715-9b22-b231fd65cc2b
date added to LUP
2026-10-02 15:28:51
date last changed
2026-10-03 03:33:53
@article{27cf02e4-f732-4715-9b22-b231fd65cc2b,
  abstract     = {{<p>Background. Seismocardiography (SCG) is a non-invasive, wearable technology that captures mechanical vibrations of the heart, offering a potential low-cost tool for assessing cardiac function. While conventional imaging modalities such as transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR) provide detailed structural and volumetric measures, they are operator-dependent and require specialized training. This study aimed to evaluate the correlation between SCG, TTE and CMR markers of systolic and diastolic function in healthy individuals and those with cardiovascular disease (CVD). Methods. Twenty-six subjects (age 45 ± 16 years and 77% male) were included, 10 healthy subjects and 16 subjects with CVD. All subjects underwent SCG, TTE, and CMR measurements before and after intravenous infusion of 2.0 l isotonic saline. SCG signals were segmented into individual heartbeats, and fiducial points were automatically detected and manually validated. Results. SCG amplitudes Cd-to-Dd and Dd demonstrated moderate correlations with the diastolic parameter e′ from TTE (r = 0.42–0.66), while SCG time intervals Gs-Bd and Ls-Bd correlated moderately with LVET (r = 0.51–0.66). These associations were consistent across both healthy participants and patients with CVD. Conclusion. SCG-derived measures correlate moderately with TTE markers of diastolic (e′) and systolic (LVET) function, and these associations are preserved in both healthy and CVD subgroups, indicating robustness across clinical phenotypes. The findings in this study support SCG’s potential as a non-invasive tool for assessing mechanical cardiac function. However, further validation in real-world wearable settings is required.</p>}},
  author       = {{Agam, Ahmad and Korsgaard, Emil and Kragholm, Kristian and Kristensen, Charlotte Burup and Mogelvang, Rasmus and Emerek, Kasper Janus Grønn and Schmidt, Samuel Emil and Søgaard, Peter}},
  issn         = {{2057-1976}},
  keywords     = {{cardiac function; cardiac magnetic resonance; correlation; diastolic; echocardiography; SCG; seismocardiogram; Seismocardiography; systolic}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{IOP Publishing}},
  series       = {{Biomedical Physics and Engineering Express}},
  title        = {{Correlation of seismocardiography variables with echocardiographic and cardiac magnetic resonance measurements}},
  url          = {{http://dx.doi.org/10.1088/2057-1976/ae93bc}},
  doi          = {{10.1088/2057-1976/ae93bc}},
  volume       = {{12}},
  year         = {{2026}},
}