Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering
Metzger, F. Luise ; Auer, Tibor ; Helms, Gunther LU
; Paulus, Walter
; Frahm, Jens
; Sommer, Martin
and Neef, Nicole E.
(2018)
In Brain Structure and Function
223(1).
p.165-182
- Abstract
Persistent developmental stuttering is associated with basal ganglia dysfunction or dopamine dysregulation. Here, we studied whole-brain functional connectivity to test how basal ganglia structures coordinate and reorganize sensorimotor brain networks in stuttering. To this end, adults who stutter and fluent speakers (control participants) performed a response anticipation paradigm in the MRI scanner. The preparation of a manual Go/No-Go response reliably produced activity in the basal ganglia and thalamus and particularly in the substantia nigra. Strikingly, in adults who stutter, substantia nigra activity correlated positively with stuttering severity. Furthermore, functional connectivity analyses yielded altered task-related network... (More)
Persistent developmental stuttering is associated with basal ganglia dysfunction or dopamine dysregulation. Here, we studied whole-brain functional connectivity to test how basal ganglia structures coordinate and reorganize sensorimotor brain networks in stuttering. To this end, adults who stutter and fluent speakers (control participants) performed a response anticipation paradigm in the MRI scanner. The preparation of a manual Go/No-Go response reliably produced activity in the basal ganglia and thalamus and particularly in the substantia nigra. Strikingly, in adults who stutter, substantia nigra activity correlated positively with stuttering severity. Furthermore, functional connectivity analyses yielded altered task-related network formations in adults who stutter compared to fluent speakers. Specifically, in adults who stutter, the globus pallidus and the thalamus showed increased network synchronization with the inferior frontal gyrus. This implies dynamic shifts in the response preparation-related network organization through the basal ganglia in the context of a non-speech motor task in stuttering. Here we discuss current findings in the traditional framework of how D1 and D2 receptor activity shapes focused movement selection, thereby suggesting a disproportional involvement of the direct and the indirect pathway in stuttering.
(Less)
- author
- Metzger, F. Luise
; Auer, Tibor
; Helms, Gunther
LU
; Paulus, Walter
; Frahm, Jens
; Sommer, Martin
and Neef, Nicole E.
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Basal ganglia, Disinhibition, Inferior frontal gyrus, Persistent developmental stuttering, Response anticipation, Substantia nigra
- in
- Brain Structure and Function
- volume
- 223
- issue
- 1
- pages
- 165 - 182
- publisher
- Springer
- external identifiers
-
- scopus:85025703583
- pmid:28741037
- ISSN
- 1863-2653
- DOI
- 10.1007/s00429-017-1476-1
- language
- English
- LU publication?
- yes
- id
- 27d82c26-e36a-40f1-b285-846d4086f42f
- date added to LUP
- 2017-08-24 16:44:29
- date last changed
- 2024-03-31 15:13:04
@article{27d82c26-e36a-40f1-b285-846d4086f42f,
abstract = {{<p>Persistent developmental stuttering is associated with basal ganglia dysfunction or dopamine dysregulation. Here, we studied whole-brain functional connectivity to test how basal ganglia structures coordinate and reorganize sensorimotor brain networks in stuttering. To this end, adults who stutter and fluent speakers (control participants) performed a response anticipation paradigm in the MRI scanner. The preparation of a manual Go/No-Go response reliably produced activity in the basal ganglia and thalamus and particularly in the substantia nigra. Strikingly, in adults who stutter, substantia nigra activity correlated positively with stuttering severity. Furthermore, functional connectivity analyses yielded altered task-related network formations in adults who stutter compared to fluent speakers. Specifically, in adults who stutter, the globus pallidus and the thalamus showed increased network synchronization with the inferior frontal gyrus. This implies dynamic shifts in the response preparation-related network organization through the basal ganglia in the context of a non-speech motor task in stuttering. Here we discuss current findings in the traditional framework of how D1 and D2 receptor activity shapes focused movement selection, thereby suggesting a disproportional involvement of the direct and the indirect pathway in stuttering.</p>}},
author = {{Metzger, F. Luise and Auer, Tibor and Helms, Gunther and Paulus, Walter and Frahm, Jens and Sommer, Martin and Neef, Nicole E.}},
issn = {{1863-2653}},
keywords = {{Basal ganglia; Disinhibition; Inferior frontal gyrus; Persistent developmental stuttering; Response anticipation; Substantia nigra}},
language = {{eng}},
number = {{1}},
pages = {{165--182}},
publisher = {{Springer}},
series = {{Brain Structure and Function}},
title = {{Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering}},
url = {{http://dx.doi.org/10.1007/s00429-017-1476-1}},
doi = {{10.1007/s00429-017-1476-1}},
volume = {{223}},
year = {{2018}},
}