The pigmented life of a redhead.
(2004) In Pigment Cell Research 17(2). p.191-202- Abstract
- As a redhead I have had a personal interest in red hair, freckles and sunburns since childhood. An observation of a formaldehyde-induced fluorescence in human epidermal melanocytes initiated my scientific interest in these cells. Prota and Nicolaus demonstrated that oxidation products of cysteinyldopas are the main components of pheomelanin. Our identification of 5-S-cysteinyldopa as the source of formaldehyde-induced fluorescence of normal and pathological melanocytes started a series of investigations into this amino acid, enzymatic and non-enzymatic oxidation of catecholic compounds and the metabolism of thiols. All melanocytes with functioning tyrosinase produce cysteinyldopas and the levels of 5-S-cysteinyldopa in serum and urine are... (More)
- As a redhead I have had a personal interest in red hair, freckles and sunburns since childhood. An observation of a formaldehyde-induced fluorescence in human epidermal melanocytes initiated my scientific interest in these cells. Prota and Nicolaus demonstrated that oxidation products of cysteinyldopas are the main components of pheomelanin. Our identification of 5-S-cysteinyldopa as the source of formaldehyde-induced fluorescence of normal and pathological melanocytes started a series of investigations into this amino acid, enzymatic and non-enzymatic oxidation of catecholic compounds and the metabolism of thiols. All melanocytes with functioning tyrosinase produce cysteinyldopas and the levels of 5-S-cysteinyldopa in serum and urine are related to the size and pigment forming activity of the melanocyte population. The determination of 5-S-cysteinyldopa in serum or urine is a sensitive diagnostic method in the detection of melanoma metastasis. Some non-specific formation of cysteinyldopa is present in the body, as demonstrated by 5-S-cysteinyldopa in individuals with tyrosinase-negative albinism. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/121331
- author
- Rorsman, Hans LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pigment Cell Research
- volume
- 17
- issue
- 2
- pages
- 191 - 202
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000220175000014
- pmid:15016311
- scopus:1842525328
- pmid:15016311
- ISSN
- 0893-5785
- DOI
- 10.1111/j.1600-0749.2003.00127.x
- language
- English
- LU publication?
- yes
- id
- 27fdcdcd-3aa1-4a32-90ee-10e9b6722eb4 (old id 121331)
- alternative location
- http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15016311&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
- date added to LUP
- 2016-04-01 11:34:32
- date last changed
- 2022-03-12 21:44:39
@article{27fdcdcd-3aa1-4a32-90ee-10e9b6722eb4,
abstract = {{As a redhead I have had a personal interest in red hair, freckles and sunburns since childhood. An observation of a formaldehyde-induced fluorescence in human epidermal melanocytes initiated my scientific interest in these cells. Prota and Nicolaus demonstrated that oxidation products of cysteinyldopas are the main components of pheomelanin. Our identification of 5-S-cysteinyldopa as the source of formaldehyde-induced fluorescence of normal and pathological melanocytes started a series of investigations into this amino acid, enzymatic and non-enzymatic oxidation of catecholic compounds and the metabolism of thiols. All melanocytes with functioning tyrosinase produce cysteinyldopas and the levels of 5-S-cysteinyldopa in serum and urine are related to the size and pigment forming activity of the melanocyte population. The determination of 5-S-cysteinyldopa in serum or urine is a sensitive diagnostic method in the detection of melanoma metastasis. Some non-specific formation of cysteinyldopa is present in the body, as demonstrated by 5-S-cysteinyldopa in individuals with tyrosinase-negative albinism.}},
author = {{Rorsman, Hans}},
issn = {{0893-5785}},
language = {{eng}},
number = {{2}},
pages = {{191--202}},
publisher = {{Wiley-Blackwell}},
series = {{Pigment Cell Research}},
title = {{The pigmented life of a redhead.}},
url = {{https://lup.lub.lu.se/search/files/2547601/623973.pdf}},
doi = {{10.1111/j.1600-0749.2003.00127.x}},
volume = {{17}},
year = {{2004}},
}