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Modelling of nonlinear effects and the response of ultrasound contrast micro bubbles: simulation and experiment

Kvikliene, A; Jurkonis, R; Ressner, M; Hoff, L; Jansson, Tomas LU ; Janerot-Sjoberg, B; Lukosevicius, A and Ask, P (2004) Ultrasonics International 2003 In Proceedings of Ultrasonics International 2003 (Ultrasonics) 42(1-9). p.301-307
Abstract
The propagation of diagnostic ultrasonic imaging pulses in tissue and their interaction with contrast micro bubbles is a very complex physical process, which we assumed to be separable into three stages: pulse propagation in tissue, the interaction of the pulse with the contrast bubble, and the propagation of the scattered echo. The model driven approach is used to gain better knowledge of the complex processes involved. A simplified way of field simulation is chosen due to the complexity of the task and the necessity to estimate comparative contributions of each component of the process. Simulations are targeted at myocardial perfusion estimation. A modified method for spatial superposition of attenuated waves enables simulations of low... (More)
The propagation of diagnostic ultrasonic imaging pulses in tissue and their interaction with contrast micro bubbles is a very complex physical process, which we assumed to be separable into three stages: pulse propagation in tissue, the interaction of the pulse with the contrast bubble, and the propagation of the scattered echo. The model driven approach is used to gain better knowledge of the complex processes involved. A simplified way of field simulation is chosen due to the complexity of the task and the necessity to estimate comparative contributions of each component of the process. Simulations are targeted at myocardial perfusion estimation. A modified method for spatial superposition of attenuated waves enables simulations of low intensity pulse pressure fields from weakly focused transducers in a nonlinear, attenuating, and liquid-like biological medium. These assumptions enable the use of quasi-linear calculations of the acoustic field. The simulations of acoustic bubble response are carried out with the Rayleigh-Plesset equation with the addition of radiation damping. Theoretical simulations with synthesised and experimentally sampled pulses show that the interaction of the excitation pulses with the contrast bubbles is the main cause of nonlinear scattering, and a 2-3 dB increase of second harmonic amplitude depends on nonlinear distortions of the incident pulse. (C) 2004 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
contrast agents, simulation, nonlinear, ultrasound
in
Proceedings of Ultrasonics International 2003 (Ultrasonics)
volume
42
issue
1-9
pages
301 - 307
publisher
Elsevier
conference name
Ultrasonics International 2003
external identifiers
  • pmid:15047302
  • wos:000220820500050
  • scopus:1642601752
ISSN
0041-624X
DOI
10.1016/j.ultras.2004.01.023
language
English
LU publication?
yes
id
828817a1-845f-430b-88f5-41add1bd2c0f (old id 280578)
date added to LUP
2007-10-23 20:05:57
date last changed
2017-01-01 07:03:19
@inproceedings{828817a1-845f-430b-88f5-41add1bd2c0f,
  abstract     = {The propagation of diagnostic ultrasonic imaging pulses in tissue and their interaction with contrast micro bubbles is a very complex physical process, which we assumed to be separable into three stages: pulse propagation in tissue, the interaction of the pulse with the contrast bubble, and the propagation of the scattered echo. The model driven approach is used to gain better knowledge of the complex processes involved. A simplified way of field simulation is chosen due to the complexity of the task and the necessity to estimate comparative contributions of each component of the process. Simulations are targeted at myocardial perfusion estimation. A modified method for spatial superposition of attenuated waves enables simulations of low intensity pulse pressure fields from weakly focused transducers in a nonlinear, attenuating, and liquid-like biological medium. These assumptions enable the use of quasi-linear calculations of the acoustic field. The simulations of acoustic bubble response are carried out with the Rayleigh-Plesset equation with the addition of radiation damping. Theoretical simulations with synthesised and experimentally sampled pulses show that the interaction of the excitation pulses with the contrast bubbles is the main cause of nonlinear scattering, and a 2-3 dB increase of second harmonic amplitude depends on nonlinear distortions of the incident pulse. (C) 2004 Elsevier B.V. All rights reserved.},
  author       = {Kvikliene, A and Jurkonis, R and Ressner, M and Hoff, L and Jansson, Tomas and Janerot-Sjoberg, B and Lukosevicius, A and Ask, P},
  booktitle    = {Proceedings of Ultrasonics International 2003 (Ultrasonics)},
  issn         = {0041-624X},
  keyword      = {contrast agents,simulation,nonlinear,ultrasound},
  language     = {eng},
  number       = {1-9},
  pages        = {301--307},
  publisher    = {Elsevier},
  title        = {Modelling of nonlinear effects and the response of ultrasound contrast micro bubbles: simulation and experiment},
  url          = {http://dx.doi.org/10.1016/j.ultras.2004.01.023},
  volume       = {42},
  year         = {2004},
}