Advanced

A prospective double blind randomized study comparing the need for blood transfusion with terlipressin or a placebo during early excision and grafting of burns

Mzezewa, S; Jonsson, K; Åberg, Magnus LU ; Sjoberg, T and Salemark, Lars LU (2004) In Burns 30(3). p.236-240
Abstract
Introduction: Early excision and skin grafting has become the standard of good burn management, but it is associated with major blood loss. Aim: To determine the haemostatic effect of terlipressin compared with placebo. Material and methods: Fifty-one patients with bums of 10-20% total body surface area had early excision and split skin grafting of deep burns. The surface area of the bum wound and of the heated graft were measured by planimetry. The patients were randomly allocated to medication, either terlipressin or placebo. Blood loss and number of transfused units of blood were recorded. Results: Twenty-one patients received terlipressin, 13 received terlipressin late (cross-over) and 17 received placebo. Six out of 21 patients... (More)
Introduction: Early excision and skin grafting has become the standard of good burn management, but it is associated with major blood loss. Aim: To determine the haemostatic effect of terlipressin compared with placebo. Material and methods: Fifty-one patients with bums of 10-20% total body surface area had early excision and split skin grafting of deep burns. The surface area of the bum wound and of the heated graft were measured by planimetry. The patients were randomly allocated to medication, either terlipressin or placebo. Blood loss and number of transfused units of blood were recorded. Results: Twenty-one patients received terlipressin, 13 received terlipressin late (cross-over) and 17 received placebo. Six out of 21 patients exposed to terlipressin were transfused with eleven units of packed red blood cells. Seven out of 13 patients crossed over from placebo to terlipressin (late terlipressin) were transfused with 17 units of blood. Eight out of 17 patients exposed to the placebo were transfused with 22 units of blood (P < 0.05). Graft healing was 1055 +/- 609 cm(2) out of 1452 +/- 1811 cm(2) in terlipressin and 914 +/- 633 cm(2) out of 1288 720 cm 2 in the placebo group (n.s.). Conclusion: Terlipressin reduced the need for blood transfusion by a factor of 2.5 compared to a placebo without impairment of graft healing. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
blood loss, burns, early excision, terlipressin
in
Burns
volume
30
issue
3
pages
236 - 240
publisher
Elsevier
external identifiers
  • wos:000220969800006
  • pmid:15082350
  • scopus:1842735259
ISSN
0305-4179
DOI
10.1016/j.burns.2003.11.004
language
English
LU publication?
yes
id
bcf41376-5878-47c4-bd77-2c4162c9544a (old id 281056)
date added to LUP
2007-08-03 15:29:31
date last changed
2017-11-05 03:35:44
@article{bcf41376-5878-47c4-bd77-2c4162c9544a,
  abstract     = {Introduction: Early excision and skin grafting has become the standard of good burn management, but it is associated with major blood loss. Aim: To determine the haemostatic effect of terlipressin compared with placebo. Material and methods: Fifty-one patients with bums of 10-20% total body surface area had early excision and split skin grafting of deep burns. The surface area of the bum wound and of the heated graft were measured by planimetry. The patients were randomly allocated to medication, either terlipressin or placebo. Blood loss and number of transfused units of blood were recorded. Results: Twenty-one patients received terlipressin, 13 received terlipressin late (cross-over) and 17 received placebo. Six out of 21 patients exposed to terlipressin were transfused with eleven units of packed red blood cells. Seven out of 13 patients crossed over from placebo to terlipressin (late terlipressin) were transfused with 17 units of blood. Eight out of 17 patients exposed to the placebo were transfused with 22 units of blood (P &lt; 0.05). Graft healing was 1055 +/- 609 cm(2) out of 1452 +/- 1811 cm(2) in terlipressin and 914 +/- 633 cm(2) out of 1288 720 cm 2 in the placebo group (n.s.). Conclusion: Terlipressin reduced the need for blood transfusion by a factor of 2.5 compared to a placebo without impairment of graft healing.},
  author       = {Mzezewa, S and Jonsson, K and Åberg, Magnus and Sjoberg, T and Salemark, Lars},
  issn         = {0305-4179},
  keyword      = {blood loss,burns,early excision,terlipressin},
  language     = {eng},
  number       = {3},
  pages        = {236--240},
  publisher    = {Elsevier},
  series       = {Burns},
  title        = {A prospective double blind randomized study comparing the need for blood transfusion with terlipressin or a placebo during early excision and grafting of burns},
  url          = {http://dx.doi.org/10.1016/j.burns.2003.11.004},
  volume       = {30},
  year         = {2004},
}