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Investigation of Burkholderia cepacia nosocomial outbreak with high fatality in patients suffering from diseases other than cystic fibrosis

Shehabi, AA; Abu Al-Soud, Waleed LU ; Mahafzah, A; Khuri-bulos, N; Khader, IA; Ouis, Ibn Sina LU and Wadström, Torkel LU (2004) In Scandinavian Journal of Infectious Diseases 36(3). p.174-178
Abstract
Over a 1-y period, 26 inpatients at the Jordan University Hospital in Amman were detected with bacteraemia (23 cases) or respiratory tract colonized with B. cepacia (3 cases). A combination of genetic identification and molecular typing has proved that all cases were caused by a single epidemic strain of B. cepacia genomovar IIIa. Nosocomial infections could be documented in 21/26 (81%) patients, mostly with severe underlying or malignant diseases other than cystic fibrosis, but the source of infection was undetected. The overall mortality related to infection with B. cepacia was 42%. All B. cepacia isolates were resistant to ampicillin, amikacin, carbenicillin and gentamicin; and mostly susceptible to piperacillin, chloramphenicol,... (More)
Over a 1-y period, 26 inpatients at the Jordan University Hospital in Amman were detected with bacteraemia (23 cases) or respiratory tract colonized with B. cepacia (3 cases). A combination of genetic identification and molecular typing has proved that all cases were caused by a single epidemic strain of B. cepacia genomovar IIIa. Nosocomial infections could be documented in 21/26 (81%) patients, mostly with severe underlying or malignant diseases other than cystic fibrosis, but the source of infection was undetected. The overall mortality related to infection with B. cepacia was 42%. All B. cepacia isolates were resistant to ampicillin, amikacin, carbenicillin and gentamicin; and mostly susceptible to piperacillin, chloramphenicol, cotri-moxazole, tetracycline, ceftazidime, and tazocin (62-88%). This study demonstrates the nosocomial and high fatality of B. cepacia genomovar IIIa in Jordanian patients suffering from diseases other than cystic fibrosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
36
issue
3
pages
174 - 178
publisher
Informa Healthcare
external identifiers
  • wos:000220616200002
  • pmid:15119360
  • scopus:2442630515
ISSN
1651-1980
DOI
10.1080/00365540410027166
language
English
LU publication?
yes
id
ff491e77-7111-48dd-a05a-def8e2d0e563 (old id 282019)
date added to LUP
2007-10-31 14:37:09
date last changed
2017-09-03 04:36:36
@article{ff491e77-7111-48dd-a05a-def8e2d0e563,
  abstract     = {Over a 1-y period, 26 inpatients at the Jordan University Hospital in Amman were detected with bacteraemia (23 cases) or respiratory tract colonized with B. cepacia (3 cases). A combination of genetic identification and molecular typing has proved that all cases were caused by a single epidemic strain of B. cepacia genomovar IIIa. Nosocomial infections could be documented in 21/26 (81%) patients, mostly with severe underlying or malignant diseases other than cystic fibrosis, but the source of infection was undetected. The overall mortality related to infection with B. cepacia was 42%. All B. cepacia isolates were resistant to ampicillin, amikacin, carbenicillin and gentamicin; and mostly susceptible to piperacillin, chloramphenicol, cotri-moxazole, tetracycline, ceftazidime, and tazocin (62-88%). This study demonstrates the nosocomial and high fatality of B. cepacia genomovar IIIa in Jordanian patients suffering from diseases other than cystic fibrosis.},
  author       = {Shehabi, AA and Abu Al-Soud, Waleed and Mahafzah, A and Khuri-bulos, N and Khader, IA and Ouis, Ibn Sina and Wadström, Torkel},
  issn         = {1651-1980},
  language     = {eng},
  number       = {3},
  pages        = {174--178},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Investigation of Burkholderia cepacia nosocomial outbreak with high fatality in patients suffering from diseases other than cystic fibrosis},
  url          = {http://dx.doi.org/10.1080/00365540410027166},
  volume       = {36},
  year         = {2004},
}