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Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls

Haukvik, U. K.; Schaer, M.; Nesvag, R.; McNeil, Thomas LU ; Hartberg, C. B.; Jonsson, E. G.; Eliez, S. and Agartz, I. (2012) In Psychological Medicine 42(6). p.1329-1337
Abstract
Background. The increased occurrence of obstetric complications (OCs) in patients with schizophrenia suggests that alterations in neurodevelopment may be of importance to the aetiology of the illness. Abnormal cortical folding may reflect subtle deviation from normal neurodevelopment during the foetal or neonatal period. In the present study, we hypothesized that OCs would be related to cortical folding abnormalities in schizophrenia patients corresponding to areas where patients with schizophrenia display altered cortical folding when compared with healthy controls. Method. In total, 54 schizophrenia patients and 54 healthy control subjects underwent clinical examination and magnetic resonance image scanning on a 1.5 T scanner.... (More)
Background. The increased occurrence of obstetric complications (OCs) in patients with schizophrenia suggests that alterations in neurodevelopment may be of importance to the aetiology of the illness. Abnormal cortical folding may reflect subtle deviation from normal neurodevelopment during the foetal or neonatal period. In the present study, we hypothesized that OCs would be related to cortical folding abnormalities in schizophrenia patients corresponding to areas where patients with schizophrenia display altered cortical folding when compared with healthy controls. Method. In total, 54 schizophrenia patients and 54 healthy control subjects underwent clinical examination and magnetic resonance image scanning on a 1.5 T scanner. Information on OCs was collected from original birth records. An automated algorithm was used to calculate a three-dimensional local gyrification index (lGI) at numerous points across the cortical mantle. Results. In both schizophrenia patients and healthy controls, an increasing number of OCs was significantly related to lower lGI in the left pars triangularis (p<0.0005) in Broca's area. For five other anatomical cortical parcellations in the left hemisphere, a similar trend was demonstrated. No significant relationships between OCs and lGI were found in the right hemisphere and there were no significant case-control differences in lGI. Conclusions. The reduced cortical folding in the left pars triangularis, associated with OCs in both patients and control subjects suggests that the cortical effect of OCs is caused by factors shared by schizophrenia patients and healthy controls rather than factors related to schizophrenia alone. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Broca's area, gyrification, MRI, neurodevelopment, obstetric, complications, schizophrenia
in
Psychological Medicine
volume
42
issue
6
pages
1329 - 1337
publisher
Cambridge University Press
external identifiers
  • wos:000303825800019
  • scopus:84860748199
ISSN
1469-8978
DOI
10.1017/S0033291711002315
language
English
LU publication?
yes
id
38f3765e-c65f-4383-b91a-80b9696daff0 (old id 2826517)
date added to LUP
2012-07-03 10:26:22
date last changed
2017-09-17 03:29:12
@article{38f3765e-c65f-4383-b91a-80b9696daff0,
  abstract     = {Background. The increased occurrence of obstetric complications (OCs) in patients with schizophrenia suggests that alterations in neurodevelopment may be of importance to the aetiology of the illness. Abnormal cortical folding may reflect subtle deviation from normal neurodevelopment during the foetal or neonatal period. In the present study, we hypothesized that OCs would be related to cortical folding abnormalities in schizophrenia patients corresponding to areas where patients with schizophrenia display altered cortical folding when compared with healthy controls. Method. In total, 54 schizophrenia patients and 54 healthy control subjects underwent clinical examination and magnetic resonance image scanning on a 1.5 T scanner. Information on OCs was collected from original birth records. An automated algorithm was used to calculate a three-dimensional local gyrification index (lGI) at numerous points across the cortical mantle. Results. In both schizophrenia patients and healthy controls, an increasing number of OCs was significantly related to lower lGI in the left pars triangularis (p&lt;0.0005) in Broca's area. For five other anatomical cortical parcellations in the left hemisphere, a similar trend was demonstrated. No significant relationships between OCs and lGI were found in the right hemisphere and there were no significant case-control differences in lGI. Conclusions. The reduced cortical folding in the left pars triangularis, associated with OCs in both patients and control subjects suggests that the cortical effect of OCs is caused by factors shared by schizophrenia patients and healthy controls rather than factors related to schizophrenia alone.},
  author       = {Haukvik, U. K. and Schaer, M. and Nesvag, R. and McNeil, Thomas and Hartberg, C. B. and Jonsson, E. G. and Eliez, S. and Agartz, I.},
  issn         = {1469-8978},
  keyword      = {Broca's area,gyrification,MRI,neurodevelopment,obstetric,complications,schizophrenia},
  language     = {eng},
  number       = {6},
  pages        = {1329--1337},
  publisher    = {Cambridge University Press},
  series       = {Psychological Medicine},
  title        = {Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls},
  url          = {http://dx.doi.org/10.1017/S0033291711002315},
  volume       = {42},
  year         = {2012},
}