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A Pilot Study Examining Associations between DYRK1A and alpha-Synuclein Dementias

Jones, Emma L.; Aarsland, Dag; Londos, Elisabet LU and Ballard, Clive (2012) In Neurodegenerative Diseases 10(1-4). p.229-231
Abstract
Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia. Methods: DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism. Results: The rs8126696 polymorphism altered the risk of developing an alpha-synuclein-associated dementia. Conclusion: DYRK1A could prove to be an important therapeutic target as it interacts... (More)
Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia. Methods: DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism. Results: The rs8126696 polymorphism altered the risk of developing an alpha-synuclein-associated dementia. Conclusion: DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia. Copyright (C) 2012 S. Karger AG, Basel (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dementia with Lewy bodies, Parkinson's disease, Genetic association, alpha-Synuclein, DYRK1A
in
Neurodegenerative Diseases
volume
10
issue
1-4
pages
229 - 231
publisher
Karger
external identifiers
  • wos:000303660600048
  • scopus:84860220771
ISSN
1660-2862
DOI
10.1159/000334759
language
English
LU publication?
yes
id
c544053e-504b-40c9-8915-9c46d6c48ebb (old id 2826896)
date added to LUP
2012-07-03 10:27:13
date last changed
2017-01-01 04:07:37
@article{c544053e-504b-40c9-8915-9c46d6c48ebb,
  abstract     = {Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia. Methods: DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism. Results: The rs8126696 polymorphism altered the risk of developing an alpha-synuclein-associated dementia. Conclusion: DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia. Copyright (C) 2012 S. Karger AG, Basel},
  author       = {Jones, Emma L. and Aarsland, Dag and Londos, Elisabet and Ballard, Clive},
  issn         = {1660-2862},
  keyword      = {Dementia with Lewy bodies,Parkinson's disease,Genetic association,alpha-Synuclein,DYRK1A},
  language     = {eng},
  number       = {1-4},
  pages        = {229--231},
  publisher    = {Karger},
  series       = {Neurodegenerative Diseases},
  title        = {A Pilot Study Examining Associations between DYRK1A and alpha-Synuclein Dementias},
  url          = {http://dx.doi.org/10.1159/000334759},
  volume       = {10},
  year         = {2012},
}