Developing chicken oligodendrocytes express the type IV oligodendrocyte marker T4-O in situ, but not in vitro
(2000) In Neuroscience Letters 284(1-2). p.21-24- Abstract
- Accumulating data suggest that the oligodendrocyte population includes morphological and biochemical subtypes. We recently reported that a polyclonal antiserum against an unknown antigen, the T4-O molecule, labels a subpopulation of chicken oligodendrocytes, obviously representing the type IV variety of Del Rio Hortega. The present study examines the developmental expression of the T4-O molecule in situ and in vitro. The results show that T4-O immunoreactive cells first appear at E15 in the ventral funiculus. But, oligodendrocytes cultured in vitro with or without neurones do not develop a T4-O immunoreactivity. We conclude that oligodendrocytes in the spinal cord of chicken embryos first express the T4-O molecule some time after onset of... (More)
- Accumulating data suggest that the oligodendrocyte population includes morphological and biochemical subtypes. We recently reported that a polyclonal antiserum against an unknown antigen, the T4-O molecule, labels a subpopulation of chicken oligodendrocytes, obviously representing the type IV variety of Del Rio Hortega. The present study examines the developmental expression of the T4-O molecule in situ and in vitro. The results show that T4-O immunoreactive cells first appear at E15 in the ventral funiculus. But, oligodendrocytes cultured in vitro with or without neurones do not develop a T4-O immunoreactivity. We conclude that oligodendrocytes in the spinal cord of chicken embryos first express the T4-O molecule some time after onset of myelination, and that the T4-O immunoreactive phenotype does not develop in vitro. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1116917
- author
- Anderson, Emma S ; Bjartmar, Carl ; Eriksson Linsmeier, Cecilia LU ; Westermark, Gunilla and Hildebrand, Claes
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cell culture, T4-O, Myelination, Development, White matter, Spinal cord, Oligodendrocyte, Chicken
- in
- Neuroscience Letters
- volume
- 284
- issue
- 1-2
- pages
- 21 - 24
- publisher
- Elsevier
- external identifiers
-
- pmid:10771152
- scopus:0034697054
- ISSN
- 0304-3940
- DOI
- 10.1016/S0304-3940(00)00989-7
- language
- English
- LU publication?
- no
- id
- 282f0983-8fc6-442f-90e7-39ac415d5cb6 (old id 1116917)
- date added to LUP
- 2016-04-01 12:02:44
- date last changed
- 2022-01-26 22:01:48
@article{282f0983-8fc6-442f-90e7-39ac415d5cb6, abstract = {{Accumulating data suggest that the oligodendrocyte population includes morphological and biochemical subtypes. We recently reported that a polyclonal antiserum against an unknown antigen, the T4-O molecule, labels a subpopulation of chicken oligodendrocytes, obviously representing the type IV variety of Del Rio Hortega. The present study examines the developmental expression of the T4-O molecule in situ and in vitro. The results show that T4-O immunoreactive cells first appear at E15 in the ventral funiculus. But, oligodendrocytes cultured in vitro with or without neurones do not develop a T4-O immunoreactivity. We conclude that oligodendrocytes in the spinal cord of chicken embryos first express the T4-O molecule some time after onset of myelination, and that the T4-O immunoreactive phenotype does not develop in vitro.}}, author = {{Anderson, Emma S and Bjartmar, Carl and Eriksson Linsmeier, Cecilia and Westermark, Gunilla and Hildebrand, Claes}}, issn = {{0304-3940}}, keywords = {{Cell culture; T4-O; Myelination; Development; White matter; Spinal cord; Oligodendrocyte; Chicken}}, language = {{eng}}, number = {{1-2}}, pages = {{21--24}}, publisher = {{Elsevier}}, series = {{Neuroscience Letters}}, title = {{Developing chicken oligodendrocytes express the type IV oligodendrocyte marker T4-O in situ, but not in vitro}}, url = {{http://dx.doi.org/10.1016/S0304-3940(00)00989-7}}, doi = {{10.1016/S0304-3940(00)00989-7}}, volume = {{284}}, year = {{2000}}, }