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Lateral cervical nucleus projections to periaqueductal gray matter in cat

Mouton, LJ; Klop, EM; Broman, Jonas LU ; Zhang, Mengliang LU and Holstege, G (2004) In Journal of Comparative Neurology 471(4). p.434-445
Abstract
The midbrain periaqueductal gray matter (PAG) integrates the basic responses necessary for survival of individuals and species. Examples are defense behaviors such as fight, flight, and freezing, but also sexual behavior, vocalization, and micturition. To control these behaviors the PAG depends on strong input from more rostrally located limbic structures, as well as from afferent input from the lower brainstem and spinal cord. Mouton and Holstege (2000, J Comp Neurol 428:389-410) showed that there exist at least five different groups of spino-PAG neurons, each of which is thought to subserve a specific function. The lateral cervical nucleus (LCN) in the upper cervical cord is not among these five groups. The LCN relays information from... (More)
The midbrain periaqueductal gray matter (PAG) integrates the basic responses necessary for survival of individuals and species. Examples are defense behaviors such as fight, flight, and freezing, but also sexual behavior, vocalization, and micturition. To control these behaviors the PAG depends on strong input from more rostrally located limbic structures, as well as from afferent input from the lower brainstem and spinal cord. Mouton and Holstege (2000, J Comp Neurol 428:389-410) showed that there exist at least five different groups of spino-PAG neurons, each of which is thought to subserve a specific function. The lateral cervical nucleus (LCN) in the upper cervical cord is not among these five groups. The LCN relays information from hair receptors and noxious information and projects strongly to the contralateral ventroposterior and posterior regions of thalamus and to intermediate and deep tectal layers. The question is whether the LCN also projects to the PAG. The present study in cat, using retrograde and anterograde tracing techniques, showed that neurons located in the lateral two-thirds of the LCN send fibers to the lateral part of the PAG, predominantly at rostrocaudal levels A0.6-P0.2. This part of the PAG is known to be involved in flight behavior. A concept is put forward according to which the LCN-PAG pathway alerts the animal about the presence of cutaneous stimuli that might represent danger, necessitating flight. (C) 2004 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
emotional motor system, spinocervical, somatosensory, colliculus superior, tectum, spinomesencephalic
in
Journal of Comparative Neurology
volume
471
issue
4
pages
434 - 445
publisher
John Wiley & Sons
external identifiers
  • wos:000220463000003
  • pmid:15022262
  • scopus:1642441683
ISSN
1096-9861
DOI
10.1002/cne.20031
language
English
LU publication?
yes
id
470a774f-0a65-447a-b891-631b0a3351b6 (old id 283610)
date added to LUP
2007-10-28 15:54:06
date last changed
2017-04-02 03:24:18
@article{470a774f-0a65-447a-b891-631b0a3351b6,
  abstract     = {The midbrain periaqueductal gray matter (PAG) integrates the basic responses necessary for survival of individuals and species. Examples are defense behaviors such as fight, flight, and freezing, but also sexual behavior, vocalization, and micturition. To control these behaviors the PAG depends on strong input from more rostrally located limbic structures, as well as from afferent input from the lower brainstem and spinal cord. Mouton and Holstege (2000, J Comp Neurol 428:389-410) showed that there exist at least five different groups of spino-PAG neurons, each of which is thought to subserve a specific function. The lateral cervical nucleus (LCN) in the upper cervical cord is not among these five groups. The LCN relays information from hair receptors and noxious information and projects strongly to the contralateral ventroposterior and posterior regions of thalamus and to intermediate and deep tectal layers. The question is whether the LCN also projects to the PAG. The present study in cat, using retrograde and anterograde tracing techniques, showed that neurons located in the lateral two-thirds of the LCN send fibers to the lateral part of the PAG, predominantly at rostrocaudal levels A0.6-P0.2. This part of the PAG is known to be involved in flight behavior. A concept is put forward according to which the LCN-PAG pathway alerts the animal about the presence of cutaneous stimuli that might represent danger, necessitating flight. (C) 2004 Wiley-Liss, Inc.},
  author       = {Mouton, LJ and Klop, EM and Broman, Jonas and Zhang, Mengliang and Holstege, G},
  issn         = {1096-9861},
  keyword      = {emotional motor system,spinocervical,somatosensory,colliculus superior,tectum,spinomesencephalic},
  language     = {eng},
  number       = {4},
  pages        = {434--445},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Comparative Neurology},
  title        = {Lateral cervical nucleus projections to periaqueductal gray matter in cat},
  url          = {http://dx.doi.org/10.1002/cne.20031},
  volume       = {471},
  year         = {2004},
}