Micro- and nanofluidics for DNA analysis
Tegenfeldt, Jonas LU
; Prinz, Christelle
LU
; Cao, H
; Huang, RL
; Austin, RH
; Chou, SY
; Cox, EC
and Sturm, JC
(2004)
In Analytical and Bioanalytical Chemistry
378(7).
p.1678-1692
- Abstract
- Miniaturization to the micrometer and nanometer scale opens up the possibility to probe biology on a length scale where fundamental biological processes take place, such as the epigenetic and genetic control of single cells. To study single cells the necessary devices need to be integrated on a single chip; and, to access the relevant length scales, the devices need to be designed with feature sizes of a few nanometers up to several micrometers. We will give a few examples from the literature and from our own research in the field of miniaturized chip-based devices for DNA analysis, including dielectrophoresis for purification of DNA, artificial gel structures for rapid DNA separation, and nanofluidic channels for direct visualization of... (More)
- Miniaturization to the micrometer and nanometer scale opens up the possibility to probe biology on a length scale where fundamental biological processes take place, such as the epigenetic and genetic control of single cells. To study single cells the necessary devices need to be integrated on a single chip; and, to access the relevant length scales, the devices need to be designed with feature sizes of a few nanometers up to several micrometers. We will give a few examples from the literature and from our own research in the field of miniaturized chip-based devices for DNA analysis, including dielectrophoresis for purification of DNA, artificial gel structures for rapid DNA separation, and nanofluidic channels for direct visualization of single DNA molecules. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/284112
- author
- Tegenfeldt, Jonas
LU
; Prinz, Christelle
LU
; Cao, H
; Huang, RL
; Austin, RH
; Chou, SY
; Cox, EC
and Sturm, JC
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Analytical and Bioanalytical Chemistry
- volume
- 378
- issue
- 7
- pages
- 1678 - 1692
- publisher
- Springer
- external identifiers
-
- pmid:15007591
- wos:000220458400004
- scopus:12844260686
- ISSN
- 1618-2642
- DOI
- 10.1007/s00216-004-2526-0
- language
- English
- LU publication?
- yes
- id
- 13517fa7-1b10-478a-90b3-1226d3816eb4 (old id 284112)
- date added to LUP
- 2016-04-01 12:26:02
- date last changed
- 2022-02-11 06:53:17
@article{13517fa7-1b10-478a-90b3-1226d3816eb4,
abstract = {{Miniaturization to the micrometer and nanometer scale opens up the possibility to probe biology on a length scale where fundamental biological processes take place, such as the epigenetic and genetic control of single cells. To study single cells the necessary devices need to be integrated on a single chip; and, to access the relevant length scales, the devices need to be designed with feature sizes of a few nanometers up to several micrometers. We will give a few examples from the literature and from our own research in the field of miniaturized chip-based devices for DNA analysis, including dielectrophoresis for purification of DNA, artificial gel structures for rapid DNA separation, and nanofluidic channels for direct visualization of single DNA molecules.}},
author = {{Tegenfeldt, Jonas and Prinz, Christelle and Cao, H and Huang, RL and Austin, RH and Chou, SY and Cox, EC and Sturm, JC}},
issn = {{1618-2642}},
language = {{eng}},
number = {{7}},
pages = {{1678--1692}},
publisher = {{Springer}},
series = {{Analytical and Bioanalytical Chemistry}},
title = {{Micro- and nanofluidics for DNA analysis}},
url = {{http://dx.doi.org/10.1007/s00216-004-2526-0}},
doi = {{10.1007/s00216-004-2526-0}},
volume = {{378}},
year = {{2004}},
}