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Impact of endometriosis and/or adenomyosis on cumulative live birth rates under three consecutive in vitro fertilisation treatments

Alson, Sara LU orcid and Sladkevicius, Povilas LU orcid (2025) 35th World Congress on Ultrasound in Obstetrics and Gynecology In Ultrasound in Obstetrics & Gynecology 66(51). p.45-45
Abstract (Swedish)
Objectives:
To determine the cumulative live birth rate (CLBR) under three consecutive in vitro fertilisation (IVF) treatments in women with endometriosis and/or adenomyosis.

Methods:
A prospective cohort study of 1035 women aged 25–≤39 years undergoing up to three consecutive IVF treatments between January 2019 and April 2024. All women underwent an advanced transvaginal ultrasound examination prior to starting their treatments. Endometriosis/adenomyosis were diagnosed using the International Deep Endometriosis Analysis and the revised Morphological Uterus Sonographic Assessment group definitions. The aRR for cumulative live birth (CLB) after three IVF cycles was calculated using a modified Poisson regression analysis... (More)
Objectives:
To determine the cumulative live birth rate (CLBR) under three consecutive in vitro fertilisation (IVF) treatments in women with endometriosis and/or adenomyosis.

Methods:
A prospective cohort study of 1035 women aged 25–≤39 years undergoing up to three consecutive IVF treatments between January 2019 and April 2024. All women underwent an advanced transvaginal ultrasound examination prior to starting their treatments. Endometriosis/adenomyosis were diagnosed using the International Deep Endometriosis Analysis and the revised Morphological Uterus Sonographic Assessment group definitions. The aRR for cumulative live birth (CLB) after three IVF cycles was calculated using a modified Poisson regression analysis adjusting for antimüllerian hormone. In total 293 (28.3%) women had endometriosis and/or direct features of adenomyosis. All 1035 women underwent the first treatment, and 817 (78.9%) women underwent all eligible treatments.

Results:
The CLBR in the total cohort was 666/817 (81.5%). Women with endometriosis and/or adenomyosis had a lower CLBR of 156/223 (70.0%) compared to women without, 510/593 (86.0%), p < 0.001. The aRR for CLB for women with endometriosis and/or adenomyosis was 0.85 (95% CI, 0.78–0.91), p < 0.001. Stratified per treatment, the CLBR for women with endometriosis and/or adenomyosis in the first cycle was 90/293 (30.7%), aRR0.69 (95% CI, 0.57–0.84), in the second 44/154 (28.6%), aRR 0.72 (95% CI, 0.54–0.96) and in the third cycle 22/84 (26.2%), aRR 0.83 (95% CI, 0.54–1.28). For women without the disease, the CLBR was 335/742 (45.1%) in the first cycle, 132/319 (41.4%) in the second and 43/133 (32.3%) in the third.

Conclusions:
The presence of endometriosis and/or adenomyosis is associated with a reduced chance of live birth under three consecutive IVF treatments. However, the proportion of women achieving a live birth remained stable over three treatment cycles, suggesting that an unsuccessful first attempt should not be a reason to withhold further treatments. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
endometriosis, Adenomyosis, Ultrasound, Infertility, IVF outcome, IDEA, MUSA
in
Ultrasound in Obstetrics & Gynecology
volume
66
issue
51
article number
OC16.02
pages
45 - 45
publisher
John Wiley & Sons Inc.
conference name
35th World Congress on Ultrasound in Obstetrics and Gynecology
conference location
Cancun, Mexico
conference dates
2025-09-14 - 2025-09-17
ISSN
1469-0705
DOI
10.1002/uog.70054
language
English
LU publication?
yes
id
28457546-e057-4c55-b3f7-7b3bb4568b49
date added to LUP
2025-09-22 08:21:54
date last changed
2025-09-22 08:27:37
@misc{28457546-e057-4c55-b3f7-7b3bb4568b49,
  abstract     = {{Objectives:<br/>To determine the cumulative live birth rate (CLBR) under three consecutive in vitro fertilisation (IVF) treatments in women with endometriosis and/or adenomyosis.<br/><br/>Methods:<br/>A prospective cohort study of 1035 women aged 25–≤39 years undergoing up to three consecutive IVF treatments between January 2019 and April 2024. All women underwent an advanced transvaginal ultrasound examination prior to starting their treatments. Endometriosis/adenomyosis were diagnosed using the International Deep Endometriosis Analysis and the revised Morphological Uterus Sonographic Assessment group definitions. The aRR for cumulative live birth (CLB) after three IVF cycles was calculated using a modified Poisson regression analysis adjusting for antimüllerian hormone. In total 293 (28.3%) women had endometriosis and/or direct features of adenomyosis. All 1035 women underwent the first treatment, and 817 (78.9%) women underwent all eligible treatments.<br/><br/>Results:<br/>The CLBR in the total cohort was 666/817 (81.5%). Women with endometriosis and/or adenomyosis had a lower CLBR of 156/223 (70.0%) compared to women without, 510/593 (86.0%), p &lt; 0.001. The aRR for CLB for women with endometriosis and/or adenomyosis was 0.85 (95% CI, 0.78–0.91), p &lt; 0.001. Stratified per treatment, the CLBR for women with endometriosis and/or adenomyosis in the first cycle was 90/293 (30.7%), aRR0.69 (95% CI, 0.57–0.84), in the second 44/154 (28.6%), aRR 0.72 (95% CI, 0.54–0.96) and in the third cycle 22/84 (26.2%), aRR 0.83 (95% CI, 0.54–1.28). For women without the disease, the CLBR was 335/742 (45.1%) in the first cycle, 132/319 (41.4%) in the second and 43/133 (32.3%) in the third.<br/><br/>Conclusions:<br/>The presence of endometriosis and/or adenomyosis is associated with a reduced chance of live birth under three consecutive IVF treatments. However, the proportion of women achieving a live birth remained stable over three treatment cycles, suggesting that an unsuccessful first attempt should not be a reason to withhold further treatments.}},
  author       = {{Alson, Sara and Sladkevicius, Povilas}},
  issn         = {{1469-0705}},
  keywords     = {{endometriosis; Adenomyosis; Ultrasound; Infertility; IVF outcome; IDEA; MUSA}},
  language     = {{eng}},
  month        = {{09}},
  note         = {{Conference Abstract}},
  number       = {{51}},
  pages        = {{45--45}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Ultrasound in Obstetrics & Gynecology}},
  title        = {{Impact of endometriosis and/or adenomyosis on cumulative live birth rates under three consecutive in vitro fertilisation treatments}},
  url          = {{http://dx.doi.org/10.1002/uog.70054}},
  doi          = {{10.1002/uog.70054}},
  volume       = {{66}},
  year         = {{2025}},
}