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Laxative treatment elevates plasma homocysteine: a study on a population-based Swedish sample of old people

Nilsson, SE; Takkinen, S; Johansson, B; Dotevall, G; Melander, Arne LU ; Berg, S and McClearn, G (2004) In European Journal of Clinical Pharmacology 60(1). p.45-49
Abstract
Objectives. Elevated plasma homocysteine might indicate an increased risk of cancer, and cardiovascular and neurological diseases. The homocysteine level depends on the supply of folate and cobalamine, and constipation and/or laxative treatment might compromise this supply. The present study examined the impact of constipation and laxative treatment on the blood levels of homocysteine, folate and cobalamine in a population-based sample of aged people, including consideration of frailty and impaired renal function, both of which may also influence the homocysteine level. Methods. The study was based on biochemical tests in 341 females and 183 males aged 82 years or older. The concentrations of homocysteine (plasma), folate, cobalamine and... (More)
Objectives. Elevated plasma homocysteine might indicate an increased risk of cancer, and cardiovascular and neurological diseases. The homocysteine level depends on the supply of folate and cobalamine, and constipation and/or laxative treatment might compromise this supply. The present study examined the impact of constipation and laxative treatment on the blood levels of homocysteine, folate and cobalamine in a population-based sample of aged people, including consideration of frailty and impaired renal function, both of which may also influence the homocysteine level. Methods. The study was based on biochemical tests in 341 females and 183 males aged 82 years or older. The concentrations of homocysteine (plasma), folate, cobalamine and urea (serum) were measured in subjects with and without ongoing treatment with laxative drugs. Values were adjusted for age, gender and frailty, as well as for clinical diagnoses and drug therapies known to affect homocysteine levels. Results. Homocysteine levels were increased and those of folate reduced in aged subjects on laxatives. Homocysteine remained elevated after adjusting for frailty and various neurological disorders. There was no significant effect on homocysteine and folate in constipated subjects without laxatives. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
laxatives, elderly, constipation
in
European Journal of Clinical Pharmacology
volume
60
issue
1
pages
45 - 49
publisher
Springer
external identifiers
  • wos:000220190300008
  • pmid:14767628
  • scopus:1842638315
ISSN
1432-1041
DOI
10.1007/s00228-003-0721-0
language
English
LU publication?
yes
id
9494f175-ff4c-4064-95a9-0dcd2099c8e3 (old id 284892)
date added to LUP
2007-10-29 09:37:19
date last changed
2017-01-01 07:11:05
@article{9494f175-ff4c-4064-95a9-0dcd2099c8e3,
  abstract     = {Objectives. Elevated plasma homocysteine might indicate an increased risk of cancer, and cardiovascular and neurological diseases. The homocysteine level depends on the supply of folate and cobalamine, and constipation and/or laxative treatment might compromise this supply. The present study examined the impact of constipation and laxative treatment on the blood levels of homocysteine, folate and cobalamine in a population-based sample of aged people, including consideration of frailty and impaired renal function, both of which may also influence the homocysteine level. Methods. The study was based on biochemical tests in 341 females and 183 males aged 82 years or older. The concentrations of homocysteine (plasma), folate, cobalamine and urea (serum) were measured in subjects with and without ongoing treatment with laxative drugs. Values were adjusted for age, gender and frailty, as well as for clinical diagnoses and drug therapies known to affect homocysteine levels. Results. Homocysteine levels were increased and those of folate reduced in aged subjects on laxatives. Homocysteine remained elevated after adjusting for frailty and various neurological disorders. There was no significant effect on homocysteine and folate in constipated subjects without laxatives.},
  author       = {Nilsson, SE and Takkinen, S and Johansson, B and Dotevall, G and Melander, Arne and Berg, S and McClearn, G},
  issn         = {1432-1041},
  keyword      = {laxatives,elderly,constipation},
  language     = {eng},
  number       = {1},
  pages        = {45--49},
  publisher    = {Springer},
  series       = {European Journal of Clinical Pharmacology},
  title        = {Laxative treatment elevates plasma homocysteine: a study on a population-based Swedish sample of old people},
  url          = {http://dx.doi.org/10.1007/s00228-003-0721-0},
  volume       = {60},
  year         = {2004},
}