Advanced

MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant.

Åkerblom, Malin LU ; Sachdeva, Rohit LU ; Barde, Isabelle; Verp, Sonia; Gentner, Bernhard; Trono, Didier and Jakobsson, Johan LU (2012) In The Journal of neuroscience : the official journal of the Society for Neuroscience 32(26). p.8879-8889
Abstract
New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was... (More)
New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was lost. In summary, our results demonstrate that miR-124 is a neuronal fate determinant in the subventricular zone. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of neuroscience : the official journal of the Society for Neuroscience
volume
32
issue
26
pages
8879 - 8889
publisher
Society for Neuroscience
external identifiers
  • wos:000305890700013
  • pmid:22745489
  • scopus:84862872452
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.0558-12.2012
language
English
LU publication?
yes
id
3d900beb-1a17-47b3-b8dd-6535b837991f (old id 2858822)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22745489?dopt=Abstract
date added to LUP
2012-07-04 20:35:55
date last changed
2017-11-05 03:53:59
@article{3d900beb-1a17-47b3-b8dd-6535b837991f,
  abstract     = {New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was lost. In summary, our results demonstrate that miR-124 is a neuronal fate determinant in the subventricular zone.},
  author       = {Åkerblom, Malin and Sachdeva, Rohit and Barde, Isabelle and Verp, Sonia and Gentner, Bernhard and Trono, Didier and Jakobsson, Johan},
  issn         = {1529-2401},
  language     = {eng},
  number       = {26},
  pages        = {8879--8889},
  publisher    = {Society for Neuroscience},
  series       = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  title        = {MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant.},
  url          = {http://dx.doi.org/10.1523/JNEUROSCI.0558-12.2012},
  volume       = {32},
  year         = {2012},
}