MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant.
(2012) In The Journal of Neuroscience : the official journal of the Society for Neuroscience 32(26). p.8879-8889- Abstract
- New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was... (More)
- New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was lost. In summary, our results demonstrate that miR-124 is a neuronal fate determinant in the subventricular zone. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2858822
- author
- Åkerblom, Malin LU ; Sachdeva, Rohit LU ; Barde, Isabelle ; Verp, Sonia ; Gentner, Bernhard ; Trono, Didier and Jakobsson, Johan LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of Neuroscience : the official journal of the Society for Neuroscience
- volume
- 32
- issue
- 26
- pages
- 8879 - 8889
- publisher
- Society for Neuroscience
- external identifiers
-
- wos:000305890700013
- pmid:22745489
- scopus:84862872452
- pmid:22745489
- ISSN
- 1529-2401
- DOI
- 10.1523/JNEUROSCI.0558-12.2012
- language
- English
- LU publication?
- yes
- id
- 3d900beb-1a17-47b3-b8dd-6535b837991f (old id 2858822)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22745489?dopt=Abstract
- date added to LUP
- 2016-04-01 13:11:15
- date last changed
- 2024-02-24 19:45:30
@article{3d900beb-1a17-47b3-b8dd-6535b837991f, abstract = {{New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was lost. In summary, our results demonstrate that miR-124 is a neuronal fate determinant in the subventricular zone.}}, author = {{Åkerblom, Malin and Sachdeva, Rohit and Barde, Isabelle and Verp, Sonia and Gentner, Bernhard and Trono, Didier and Jakobsson, Johan}}, issn = {{1529-2401}}, language = {{eng}}, number = {{26}}, pages = {{8879--8889}}, publisher = {{Society for Neuroscience}}, series = {{The Journal of Neuroscience : the official journal of the Society for Neuroscience}}, title = {{MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant.}}, url = {{https://lup.lub.lu.se/search/files/3212515/3052921.pdf}}, doi = {{10.1523/JNEUROSCI.0558-12.2012}}, volume = {{32}}, year = {{2012}}, }