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Combined effects of brachial pulse pressure and sialic acid for risk of cardiovascular events during 40 years of follow-up in 37 843 individuals.

Khalili, Payam; Sundström, Johannes; Franklin, Stanley S; Jendle, Johan; Lundin, Fredrik; Jungner, Ingmar and Nilsson, Peter LU (2012) In Journal of Hypertension 30(9). p.1718-1724
Abstract
OBJECTIVE:

Pulse pressure (PP) is a risk marker for cardiovascular disease (CVD) in individuals 50 years and older. Inflammation is suggested to influence atherosclerosis, but could also increase PP. We aimed to examine the combined effects of PP and the inflammatory marker sialic acid, and their independent roles on CVD risk.



METHODS:

From a population-based study in Sweden between 1962 and 1965, 18 429 men and 19 414 women at the age of 50 or older were selected and followed for first CVD event until 2005. We investigated the biological interactions between sialic acid and PP. The associations of PP and sialic acid with risk of CVD were calculated by using Cox proportional hazards model. Adjustments... (More)
OBJECTIVE:

Pulse pressure (PP) is a risk marker for cardiovascular disease (CVD) in individuals 50 years and older. Inflammation is suggested to influence atherosclerosis, but could also increase PP. We aimed to examine the combined effects of PP and the inflammatory marker sialic acid, and their independent roles on CVD risk.



METHODS:

From a population-based study in Sweden between 1962 and 1965, 18 429 men and 19 414 women at the age of 50 or older were selected and followed for first CVD event until 2005. We investigated the biological interactions between sialic acid and PP. The associations of PP and sialic acid with risk of CVD were calculated by using Cox proportional hazards model. Adjustments were made for conventional risk factors, mean arterial pressure (MAP) and socioeconomic status.



RESULTS:

The mean age was 59.5 [standard deviation (SD) 6.5] years and the number of incident CVD events in men and women were 3641 and 3227, respectively. No biological interaction was seen between PP and sialic acid. In men, the adjusted hazard ratio for PP was 0.92 [95% confidence interval (CI) 0.88-0.96, P < 0.0001) for 1 SD of PP, and 1.09 (95% CI 1.05-1.13, P < 0.0001) for 1 SD of sialic acid. In women, the corresponding figures were 1.02 (95% CI 0.97-1.07, P = 0.48) and 1.09 (95% CI 1.05-1.13, P < 0.0001).



CONCLUSIONS:

Sialic acid but not PP was an independent risk factor for CVD. The risk induced by PP is highly affected by MAP. This suggests that both estimated arterial stiffness and inflammation contribute through different pathways to risk of CVD. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
30
issue
9
pages
1718 - 1724
publisher
Lippincott Williams & Wilkins
external identifiers
  • WOS:000308801600008
  • PMID:22743685
  • Scopus:84865448740
ISSN
1473-5598
DOI
10.1097/HJH.0b013e32835606ae
language
English
LU publication?
yes
id
0b2c3a3c-5323-4253-98ef-4ad9c9dde9be (old id 2858866)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22743685?dopt=Abstract
date added to LUP
2012-07-04 20:49:27
date last changed
2017-01-01 07:48:07
@article{0b2c3a3c-5323-4253-98ef-4ad9c9dde9be,
  abstract     = {OBJECTIVE:<br/><br>
Pulse pressure (PP) is a risk marker for cardiovascular disease (CVD) in individuals 50 years and older. Inflammation is suggested to influence atherosclerosis, but could also increase PP. We aimed to examine the combined effects of PP and the inflammatory marker sialic acid, and their independent roles on CVD risk. <br/><br>
<br/><br>
METHODS:<br/><br>
From a population-based study in Sweden between 1962 and 1965, 18 429 men and 19 414 women at the age of 50 or older were selected and followed for first CVD event until 2005. We investigated the biological interactions between sialic acid and PP. The associations of PP and sialic acid with risk of CVD were calculated by using Cox proportional hazards model. Adjustments were made for conventional risk factors, mean arterial pressure (MAP) and socioeconomic status. <br/><br>
<br/><br>
RESULTS:<br/><br>
The mean age was 59.5 [standard deviation (SD) 6.5] years and the number of incident CVD events in men and women were 3641 and 3227, respectively. No biological interaction was seen between PP and sialic acid. In men, the adjusted hazard ratio for PP was 0.92 [95% confidence interval (CI) 0.88-0.96, P &lt; 0.0001) for 1 SD of PP, and 1.09 (95% CI 1.05-1.13, P &lt; 0.0001) for 1 SD of sialic acid. In women, the corresponding figures were 1.02 (95% CI 0.97-1.07, P = 0.48) and 1.09 (95% CI 1.05-1.13, P &lt; 0.0001). <br/><br>
<br/><br>
CONCLUSIONS:<br/><br>
Sialic acid but not PP was an independent risk factor for CVD. The risk induced by PP is highly affected by MAP. This suggests that both estimated arterial stiffness and inflammation contribute through different pathways to risk of CVD.},
  author       = {Khalili, Payam and Sundström, Johannes and Franklin, Stanley S and Jendle, Johan and Lundin, Fredrik and Jungner, Ingmar and Nilsson, Peter},
  issn         = {1473-5598},
  language     = {eng},
  number       = {9},
  pages        = {1718--1724},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Combined effects of brachial pulse pressure and sialic acid for risk of cardiovascular events during 40 years of follow-up in 37 843 individuals.},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e32835606ae},
  volume       = {30},
  year         = {2012},
}