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Primary peak and chronic malaria infection levels are correlated in experimentally infected great reed warblers.

Muhammad, Asghar LU ; Westerdahl, Helena LU ; Zehtindjiev, Pavel; Ilieva, Mihaela; Hasselquist, Dennis LU and Bensch, Staffan LU (2012) In Parasitology 139(10). p.1246-1252
Abstract
SUMMARY

Malaria parasites often manage to maintain an infection for several months or years in their vertebrate hosts. In humans, rodents and birds, most of the fitness costs associated with malaria infections are in the short initial primary (high parasitaemia) phase of the infection, whereas the chronic phase (low parasitaemia) is more benign to the host. In wild birds, malaria parasites have mainly been studied during the chronic phase of the infection. This is because the initial primary phase of infection is short in duration and infected birds with severe disease symptoms tend to hide in sheltered places and are thus rarely caught and sampled. We therefore wanted to investigate the relationship between the parasitaemia... (More)
SUMMARY

Malaria parasites often manage to maintain an infection for several months or years in their vertebrate hosts. In humans, rodents and birds, most of the fitness costs associated with malaria infections are in the short initial primary (high parasitaemia) phase of the infection, whereas the chronic phase (low parasitaemia) is more benign to the host. In wild birds, malaria parasites have mainly been studied during the chronic phase of the infection. This is because the initial primary phase of infection is short in duration and infected birds with severe disease symptoms tend to hide in sheltered places and are thus rarely caught and sampled. We therefore wanted to investigate the relationship between the parasitaemia during the primary and chronic phases of the infection using an experimental infection approach. We found a significant positive correlation between parasitaemia in the primary peak and the subsequent chronic phase of infection when we experimentally infected great reed warblers (Acrocephalus arundinaceus) with Plasmodium ashfordi. The reason for this association remains to be understood, but might arise from individual variation in exoerythrocytic parasite reservoirs in hosts, parasite antigenic diversity and/or host genetics. Our results suggest that the chronic phase parasitaemia can be used to qualitatively infer the parasitaemia of the preceding and more severe primary phase, which is a very important finding for studies of avian malaria in wild populations. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Plasmodium ashfordi, Acrocephalus arundinaceus, parasitaemia, primary, infections, chronic infections
in
Parasitology
volume
139
issue
10
pages
1246 - 1252
publisher
Cambridge University Press
external identifiers
  • wos:000308657800002
  • pmid:22716664
  • scopus:84866065786
ISSN
1469-8161
DOI
10.1017/S0031182012000510
project
Malaria in birds
CAnMove
language
English
LU publication?
yes
id
5bee9a12-502f-4cf6-bcdd-8e9581dae408 (old id 2859224)
date added to LUP
2012-07-06 14:42:14
date last changed
2017-10-29 03:15:33
@article{5bee9a12-502f-4cf6-bcdd-8e9581dae408,
  abstract     = {SUMMARY<br/><br>
Malaria parasites often manage to maintain an infection for several months or years in their vertebrate hosts. In humans, rodents and birds, most of the fitness costs associated with malaria infections are in the short initial primary (high parasitaemia) phase of the infection, whereas the chronic phase (low parasitaemia) is more benign to the host. In wild birds, malaria parasites have mainly been studied during the chronic phase of the infection. This is because the initial primary phase of infection is short in duration and infected birds with severe disease symptoms tend to hide in sheltered places and are thus rarely caught and sampled. We therefore wanted to investigate the relationship between the parasitaemia during the primary and chronic phases of the infection using an experimental infection approach. We found a significant positive correlation between parasitaemia in the primary peak and the subsequent chronic phase of infection when we experimentally infected great reed warblers (Acrocephalus arundinaceus) with Plasmodium ashfordi. The reason for this association remains to be understood, but might arise from individual variation in exoerythrocytic parasite reservoirs in hosts, parasite antigenic diversity and/or host genetics. Our results suggest that the chronic phase parasitaemia can be used to qualitatively infer the parasitaemia of the preceding and more severe primary phase, which is a very important finding for studies of avian malaria in wild populations.},
  author       = {Muhammad, Asghar and Westerdahl, Helena and Zehtindjiev, Pavel and Ilieva, Mihaela and Hasselquist, Dennis and Bensch, Staffan},
  issn         = {1469-8161},
  keyword      = {Plasmodium ashfordi,Acrocephalus arundinaceus,parasitaemia,primary,infections,chronic infections},
  language     = {eng},
  number       = {10},
  pages        = {1246--1252},
  publisher    = {Cambridge University Press},
  series       = {Parasitology},
  title        = {Primary peak and chronic malaria infection levels are correlated in experimentally infected great reed warblers.},
  url          = {http://dx.doi.org/10.1017/S0031182012000510},
  volume       = {139},
  year         = {2012},
}