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Fate of citalopram during water treatment with O(3), ClO(2), UV and fenton oxidation

Hörsing, Maritha LU ; Kosjek, Tina; Andersen, Henrik R; Heath, Ester and Ledin, Anna LU (2012) In Chemosphere 89(2). p.129-135
Abstract
In the present study we investigate the fate of citalopram (CIT) at neutral pH using advanced water treatment technologies that include O(3), ClO(2) oxidation, UV irradiation and Fenton oxidation. The ozonation resulted in 80% reduction after 30min treatment. Oxidation with ClO(2) removed>90% CIT at a dosage of 0.1mgL(-1). During UV irradiation 85% reduction was achieved after 5min, while Fenton with addition of 14mgL(-1) (Fe(2+)) resulted in 90% reduction of CIT. During these treatment experiments transformation products (TPs) were formed from CIT, where five compounds were identified by using high resolution and tandem mass spectrometry. Among these desmethyl-citalopram and citalopram N-oxide have been previously identified as human... (More)
In the present study we investigate the fate of citalopram (CIT) at neutral pH using advanced water treatment technologies that include O(3), ClO(2) oxidation, UV irradiation and Fenton oxidation. The ozonation resulted in 80% reduction after 30min treatment. Oxidation with ClO(2) removed>90% CIT at a dosage of 0.1mgL(-1). During UV irradiation 85% reduction was achieved after 5min, while Fenton with addition of 14mgL(-1) (Fe(2+)) resulted in 90% reduction of CIT. During these treatment experiments transformation products (TPs) were formed from CIT, where five compounds were identified by using high resolution and tandem mass spectrometry. Among these desmethyl-citalopram and citalopram N-oxide have been previously identified as human metabolites, while three are novel and published here for the first time. The three TPs are a hydroxylated dimethylamino-side chain derivative, a butyrolactone derivative and a defluorinated derivative of CIT. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Transformation product, Citalopram, O-3, ClO2, UV, Fenton
in
Chemosphere
volume
89
issue
2
pages
129 - 135
publisher
Elsevier
external identifiers
  • wos:000307615500001
  • pmid:22704974
  • scopus:84863821761
ISSN
1879-1298
DOI
10.1016/j.chemosphere.2012.05.024
language
English
LU publication?
yes
id
c924c31e-b403-4d17-9b76-9ca47013d9a2 (old id 2859338)
date added to LUP
2012-07-06 15:40:36
date last changed
2017-11-12 03:13:33
@article{c924c31e-b403-4d17-9b76-9ca47013d9a2,
  abstract     = {In the present study we investigate the fate of citalopram (CIT) at neutral pH using advanced water treatment technologies that include O(3), ClO(2) oxidation, UV irradiation and Fenton oxidation. The ozonation resulted in 80% reduction after 30min treatment. Oxidation with ClO(2) removed>90% CIT at a dosage of 0.1mgL(-1). During UV irradiation 85% reduction was achieved after 5min, while Fenton with addition of 14mgL(-1) (Fe(2+)) resulted in 90% reduction of CIT. During these treatment experiments transformation products (TPs) were formed from CIT, where five compounds were identified by using high resolution and tandem mass spectrometry. Among these desmethyl-citalopram and citalopram N-oxide have been previously identified as human metabolites, while three are novel and published here for the first time. The three TPs are a hydroxylated dimethylamino-side chain derivative, a butyrolactone derivative and a defluorinated derivative of CIT.},
  author       = {Hörsing, Maritha and Kosjek, Tina and Andersen, Henrik R and Heath, Ester and Ledin, Anna},
  issn         = {1879-1298},
  keyword      = {Transformation product,Citalopram,O-3,ClO2,UV,Fenton},
  language     = {eng},
  number       = {2},
  pages        = {129--135},
  publisher    = {Elsevier},
  series       = {Chemosphere},
  title        = {Fate of citalopram during water treatment with O(3), ClO(2), UV and fenton oxidation},
  url          = {http://dx.doi.org/10.1016/j.chemosphere.2012.05.024},
  volume       = {89},
  year         = {2012},
}