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Oxidized Dextran as Crosslinker for Chitosan Cryogel Scaffolds and Formation of Polyelectrolyte Complexes between Chitosan and Gelatin.

Berillo, Dmitriy; Elowsson, Linda LU and Kirsebom, Harald (2012) In Macromolecular Bioscience 12(8). p.1090-1099
Abstract
Macroporous scaffolds composed of chitosan and using oxidized dextran as a crosslinker are produced through cryogelation. Introducing gelatin as a third component into the structure results in the formation of mesopores in the pore walls, which are not seen if gelatin is excluded. The mesoporous structure is explained by the formation of polyelectrolyte complexes between chitosan and gelatin before crosslinking takes place. The scaffolds exhibit highly elastic properties withstanding compressions up to 60%. The in vitro biocompatibility of the cryogels is evaluated using fibroblasts from a mouse cell line (L929) and it is seen that the cells adhere and proliferate on the scaffolds. The mesoporous structure seems to have a positive effect... (More)
Macroporous scaffolds composed of chitosan and using oxidized dextran as a crosslinker are produced through cryogelation. Introducing gelatin as a third component into the structure results in the formation of mesopores in the pore walls, which are not seen if gelatin is excluded. The mesoporous structure is explained by the formation of polyelectrolyte complexes between chitosan and gelatin before crosslinking takes place. The scaffolds exhibit highly elastic properties withstanding compressions up to 60%. The in vitro biocompatibility of the cryogels is evaluated using fibroblasts from a mouse cell line (L929) and it is seen that the cells adhere and proliferate on the scaffolds. The mesoporous structure seems to have a positive effect on proliferation. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Macromolecular Bioscience
volume
12
issue
8
pages
1090 - 1099
publisher
John Wiley & Sons
external identifiers
  • wos:000307218500011
  • pmid:22674878
  • scopus:84864797942
ISSN
1616-5195
DOI
10.1002/mabi.201200023
language
English
LU publication?
yes
id
04d3ae23-8f40-46cb-8548-4ced696994ad (old id 2859716)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22674878?dopt=Abstract
date added to LUP
2012-07-04 11:32:19
date last changed
2017-04-09 04:31:33
@article{04d3ae23-8f40-46cb-8548-4ced696994ad,
  abstract     = {Macroporous scaffolds composed of chitosan and using oxidized dextran as a crosslinker are produced through cryogelation. Introducing gelatin as a third component into the structure results in the formation of mesopores in the pore walls, which are not seen if gelatin is excluded. The mesoporous structure is explained by the formation of polyelectrolyte complexes between chitosan and gelatin before crosslinking takes place. The scaffolds exhibit highly elastic properties withstanding compressions up to 60%. The in vitro biocompatibility of the cryogels is evaluated using fibroblasts from a mouse cell line (L929) and it is seen that the cells adhere and proliferate on the scaffolds. The mesoporous structure seems to have a positive effect on proliferation.},
  author       = {Berillo, Dmitriy and Elowsson, Linda and Kirsebom, Harald},
  issn         = {1616-5195},
  language     = {eng},
  number       = {8},
  pages        = {1090--1099},
  publisher    = {John Wiley & Sons},
  series       = {Macromolecular Bioscience},
  title        = {Oxidized Dextran as Crosslinker for Chitosan Cryogel Scaffolds and Formation of Polyelectrolyte Complexes between Chitosan and Gelatin.},
  url          = {http://dx.doi.org/10.1002/mabi.201200023},
  volume       = {12},
  year         = {2012},
}