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Electrochemistry of guanine and 8-oxoguanine at gold electrodes

Ferapontova, Elena LU (2004) In Electrochimica Acta 49(11). p.1751-1759
Abstract
Guanine was electrochemically oxidised at polycrystalline gold electrodes. The potential for guanine oxidation at pH 7.4 was +690 mV versus AgAgCl when extrapolated to a scan rate of 3 mV s(-1). Kinetic analysis revealed the initial irreversible 2e(-) oxidation of guanine, achieved with fast scan cyclic voltammetry. At scan rates lower than 5 V s(-1), the 2e(-) oxidation changed to the extensive 4e(-) one. The initial 2e- oxidation of guanine, observed in the first scan, resulted in a quasi-reversible 1e(-) redox process of the oxidation product in the following scans, with a formal potential (E-o/) of +263 mV. This correlated well with the redox transformations of 8-oxo-7,8-dihydroguanine (8-oxoguanine, 8-oxoG). The kinetics of guanine... (More)
Guanine was electrochemically oxidised at polycrystalline gold electrodes. The potential for guanine oxidation at pH 7.4 was +690 mV versus AgAgCl when extrapolated to a scan rate of 3 mV s(-1). Kinetic analysis revealed the initial irreversible 2e(-) oxidation of guanine, achieved with fast scan cyclic voltammetry. At scan rates lower than 5 V s(-1), the 2e(-) oxidation changed to the extensive 4e(-) one. The initial 2e- oxidation of guanine, observed in the first scan, resulted in a quasi-reversible 1e(-) redox process of the oxidation product in the following scans, with a formal potential (E-o/) of +263 mV. This correlated well with the redox transformations of 8-oxo-7,8-dihydroguanine (8-oxoguanine, 8-oxoG). The kinetics of guanine oxidation on gold is discussed in detail within Laviron's approach and compared with that of 8-oxoG. (C) 2003 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
polycrystalline gold, electrochemical oxidation, guanine, 8-oxoguanine
in
Electrochimica Acta
volume
49
issue
11
pages
1751 - 1759
publisher
Pergamon
external identifiers
  • wos:000220018600006
  • scopus:1142304491
ISSN
0013-4686
DOI
10.1016/j.electacta.2003.12.006
language
English
LU publication?
yes
id
d5e3f792-51e3-4622-9278-03d3d9aa8dec (old id 286171)
date added to LUP
2007-10-22 18:12:07
date last changed
2017-08-06 03:30:20
@article{d5e3f792-51e3-4622-9278-03d3d9aa8dec,
  abstract     = {Guanine was electrochemically oxidised at polycrystalline gold electrodes. The potential for guanine oxidation at pH 7.4 was +690 mV versus AgAgCl when extrapolated to a scan rate of 3 mV s(-1). Kinetic analysis revealed the initial irreversible 2e(-) oxidation of guanine, achieved with fast scan cyclic voltammetry. At scan rates lower than 5 V s(-1), the 2e(-) oxidation changed to the extensive 4e(-) one. The initial 2e- oxidation of guanine, observed in the first scan, resulted in a quasi-reversible 1e(-) redox process of the oxidation product in the following scans, with a formal potential (E-o/) of +263 mV. This correlated well with the redox transformations of 8-oxo-7,8-dihydroguanine (8-oxoguanine, 8-oxoG). The kinetics of guanine oxidation on gold is discussed in detail within Laviron's approach and compared with that of 8-oxoG. (C) 2003 Elsevier Ltd. All rights reserved.},
  author       = {Ferapontova, Elena},
  issn         = {0013-4686},
  keyword      = {polycrystalline gold,electrochemical oxidation,guanine,8-oxoguanine},
  language     = {eng},
  number       = {11},
  pages        = {1751--1759},
  publisher    = {Pergamon},
  series       = {Electrochimica Acta},
  title        = {Electrochemistry of guanine and 8-oxoguanine at gold electrodes},
  url          = {http://dx.doi.org/10.1016/j.electacta.2003.12.006},
  volume       = {49},
  year         = {2004},
}