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Hepatic aminotransferases of normal and IUGR fetuses in cord blood at birth

Kocylowski, Rafal; Dubiel, Mariusz; Gudmundsson, Saemundur LU ; Fritzer, Elfriede; Kiserud, Torvid and von Kaisenberg, Constantin (2012) In Early Human Development 88(7). p.461-465
Abstract
Background: The accepted standard for assessing the wellbeing of the newborn is the Apgar score and blood gas analysis. However, the prediction of neonatal morbidity or mortality is limited. In small-for-gestation (SGA) fetuses at 18-38 weeks of gestation, pO(2) is <5th centile both in the umbilical artery and vein in 30%. In a previous study in singleton term neonates cardiac specific enzymes (B-type natriuretic peptide, BNP and cardiac troponin T, cTnT) are increased in growth-restricted fetuses compared with normals. Aims: To test the hypothesis, that fetuses with intra uterine growth restriction (IUGR) have elevated AST (GOT) and ALT (GPT) aminotransferases as a result of hypoxic liver cell injury, and to establish references... (More)
Background: The accepted standard for assessing the wellbeing of the newborn is the Apgar score and blood gas analysis. However, the prediction of neonatal morbidity or mortality is limited. In small-for-gestation (SGA) fetuses at 18-38 weeks of gestation, pO(2) is <5th centile both in the umbilical artery and vein in 30%. In a previous study in singleton term neonates cardiac specific enzymes (B-type natriuretic peptide, BNP and cardiac troponin T, cTnT) are increased in growth-restricted fetuses compared with normals. Aims: To test the hypothesis, that fetuses with intra uterine growth restriction (IUGR) have elevated AST (GOT) and ALT (GPT) aminotransferases as a result of hypoxic liver cell injury, and to establish references ranges. Study design: Prospective cohort study, serum of umbilical artery (n = 156) and vein (n = 180), 599 normal singletons at 37(+0)-42(+0) weeks, neonates with IUGR (n = 41). analysis for pH, birthweight and maternal weight, spontaneous vs cesarean section, vein vs artery and for the sex. Outcome measures: Aspartate aminotransferase (AST. GOT) and Alanine aminotransferase (ALT, GPT) were measured in normals and IUGR neonates. Results: Neonates with IUGR (n = 41) had AST values that were not different from the reference group, but had significantly lower ALT (-1.49, 95% CI - 1.98 to - 1.00 vs 0.14, 95% CI - 0.42-0.13), (p<0.001), (Fig. 3). Conclusions: In neonates with IUGR, hypoxic hepatic injury markers in cord blood were not elevated. Rather, a substantially reduced ALT suggests a down-regulated hepatic activity. (C) 2011 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Development, Pediatric growth, Perinatology, Fetal medicine, Obstetrics
in
Early Human Development
volume
88
issue
7
pages
461 - 465
publisher
Elsevier
external identifiers
  • wos:000305672300002
  • scopus:84861685794
ISSN
1872-6232
DOI
10.1016/j.earlhumdev.2011.11.001
language
English
LU publication?
yes
id
8792e74a-0048-4636-a213-adea3312722c (old id 2863732)
date added to LUP
2012-08-01 09:42:43
date last changed
2017-01-01 06:34:59
@article{8792e74a-0048-4636-a213-adea3312722c,
  abstract     = {Background: The accepted standard for assessing the wellbeing of the newborn is the Apgar score and blood gas analysis. However, the prediction of neonatal morbidity or mortality is limited. In small-for-gestation (SGA) fetuses at 18-38 weeks of gestation, pO(2) is &lt;5th centile both in the umbilical artery and vein in 30%. In a previous study in singleton term neonates cardiac specific enzymes (B-type natriuretic peptide, BNP and cardiac troponin T, cTnT) are increased in growth-restricted fetuses compared with normals. Aims: To test the hypothesis, that fetuses with intra uterine growth restriction (IUGR) have elevated AST (GOT) and ALT (GPT) aminotransferases as a result of hypoxic liver cell injury, and to establish references ranges. Study design: Prospective cohort study, serum of umbilical artery (n = 156) and vein (n = 180), 599 normal singletons at 37(+0)-42(+0) weeks, neonates with IUGR (n = 41). analysis for pH, birthweight and maternal weight, spontaneous vs cesarean section, vein vs artery and for the sex. Outcome measures: Aspartate aminotransferase (AST. GOT) and Alanine aminotransferase (ALT, GPT) were measured in normals and IUGR neonates. Results: Neonates with IUGR (n = 41) had AST values that were not different from the reference group, but had significantly lower ALT (-1.49, 95% CI - 1.98 to - 1.00 vs 0.14, 95% CI - 0.42-0.13), (p&lt;0.001), (Fig. 3). Conclusions: In neonates with IUGR, hypoxic hepatic injury markers in cord blood were not elevated. Rather, a substantially reduced ALT suggests a down-regulated hepatic activity. (C) 2011 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Kocylowski, Rafal and Dubiel, Mariusz and Gudmundsson, Saemundur and Fritzer, Elfriede and Kiserud, Torvid and von Kaisenberg, Constantin},
  issn         = {1872-6232},
  keyword      = {Development,Pediatric growth,Perinatology,Fetal medicine,Obstetrics},
  language     = {eng},
  number       = {7},
  pages        = {461--465},
  publisher    = {Elsevier},
  series       = {Early Human Development},
  title        = {Hepatic aminotransferases of normal and IUGR fetuses in cord blood at birth},
  url          = {http://dx.doi.org/10.1016/j.earlhumdev.2011.11.001},
  volume       = {88},
  year         = {2012},
}