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Scope of nucleotide chemistry as studied by isothermal titration microcalorimetry

Stödeman, Magnus LU (2004) In Current Organic Chemistry 8(3). p.243-250
Abstract
The area of isothermal titration microcalorimetric (ITC) studies on solution systems involving nucleotides is reviewed. 62 references are cited. About 25 ITC studies on nucleotide systems have been published during the last two decades. The main part (ca 95%) of these papers deal with nucleotide-protein interactions and one paper involves nucleotide-nucleotide binding studies. The results of such studies include stoichiometry, the (concentration) binding constant, K-b, the enthalpy of binding, DeltaH(b)degrees, the standard Gibbs free energy of binding, DeltaG(b)degrees, the entropy of binding, DeltaS(b)degrees, and the heat capacity of binding at constant pressure, DeltaC(p)degrees. Information on proton uptake/release upon complex... (More)
The area of isothermal titration microcalorimetric (ITC) studies on solution systems involving nucleotides is reviewed. 62 references are cited. About 25 ITC studies on nucleotide systems have been published during the last two decades. The main part (ca 95%) of these papers deal with nucleotide-protein interactions and one paper involves nucleotide-nucleotide binding studies. The results of such studies include stoichiometry, the (concentration) binding constant, K-b, the enthalpy of binding, DeltaH(b)degrees, the standard Gibbs free energy of binding, DeltaG(b)degrees, the entropy of binding, DeltaS(b)degrees, and the heat capacity of binding at constant pressure, DeltaC(p)degrees. Information on proton uptake/release upon complex formation, modeling on binding cooperativity and conformational change can also be derived. In binding studies, calorimetric DeltaC(p)degrees and DeltaH(b)degrees data have been used to model the change in apolar and polar solvent accessible surface areas, DeltaASA(npol) and DeltaASA(pol) respectively. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Organic Chemistry
volume
8
issue
3
pages
243 - 250
publisher
Bentham Science Publishers
external identifiers
  • wos:000189112000004
  • scopus:1242306802
ISSN
1385-2728
language
English
LU publication?
yes
id
d26f0612-cc77-479e-a38c-d2f6184af8b5 (old id 286770)
alternative location
http://www.ingentaconnect.com/content/ben/coc/2004/00000008/00000003/art00004
date added to LUP
2016-04-01 11:39:30
date last changed
2022-01-26 08:16:53
@article{d26f0612-cc77-479e-a38c-d2f6184af8b5,
  abstract     = {{The area of isothermal titration microcalorimetric (ITC) studies on solution systems involving nucleotides is reviewed. 62 references are cited. About 25 ITC studies on nucleotide systems have been published during the last two decades. The main part (ca 95%) of these papers deal with nucleotide-protein interactions and one paper involves nucleotide-nucleotide binding studies. The results of such studies include stoichiometry, the (concentration) binding constant, K-b, the enthalpy of binding, DeltaH(b)degrees, the standard Gibbs free energy of binding, DeltaG(b)degrees, the entropy of binding, DeltaS(b)degrees, and the heat capacity of binding at constant pressure, DeltaC(p)degrees. Information on proton uptake/release upon complex formation, modeling on binding cooperativity and conformational change can also be derived. In binding studies, calorimetric DeltaC(p)degrees and DeltaH(b)degrees data have been used to model the change in apolar and polar solvent accessible surface areas, DeltaASA(npol) and DeltaASA(pol) respectively.}},
  author       = {{Stödeman, Magnus}},
  issn         = {{1385-2728}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{243--250}},
  publisher    = {{Bentham Science Publishers}},
  series       = {{Current Organic Chemistry}},
  title        = {{Scope of nucleotide chemistry as studied by isothermal titration microcalorimetry}},
  url          = {{http://www.ingentaconnect.com/content/ben/coc/2004/00000008/00000003/art00004}},
  volume       = {{8}},
  year         = {{2004}},
}