Scope of nucleotide chemistry as studied by isothermal titration microcalorimetry
(2004) In Current Organic Chemistry 8(3). p.243-250- Abstract
- The area of isothermal titration microcalorimetric (ITC) studies on solution systems involving nucleotides is reviewed. 62 references are cited. About 25 ITC studies on nucleotide systems have been published during the last two decades. The main part (ca 95%) of these papers deal with nucleotide-protein interactions and one paper involves nucleotide-nucleotide binding studies. The results of such studies include stoichiometry, the (concentration) binding constant, K-b, the enthalpy of binding, DeltaH(b)degrees, the standard Gibbs free energy of binding, DeltaG(b)degrees, the entropy of binding, DeltaS(b)degrees, and the heat capacity of binding at constant pressure, DeltaC(p)degrees. Information on proton uptake/release upon complex... (More)
- The area of isothermal titration microcalorimetric (ITC) studies on solution systems involving nucleotides is reviewed. 62 references are cited. About 25 ITC studies on nucleotide systems have been published during the last two decades. The main part (ca 95%) of these papers deal with nucleotide-protein interactions and one paper involves nucleotide-nucleotide binding studies. The results of such studies include stoichiometry, the (concentration) binding constant, K-b, the enthalpy of binding, DeltaH(b)degrees, the standard Gibbs free energy of binding, DeltaG(b)degrees, the entropy of binding, DeltaS(b)degrees, and the heat capacity of binding at constant pressure, DeltaC(p)degrees. Information on proton uptake/release upon complex formation, modeling on binding cooperativity and conformational change can also be derived. In binding studies, calorimetric DeltaC(p)degrees and DeltaH(b)degrees data have been used to model the change in apolar and polar solvent accessible surface areas, DeltaASA(npol) and DeltaASA(pol) respectively. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/286770
- author
- Stödeman, Magnus LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Organic Chemistry
- volume
- 8
- issue
- 3
- pages
- 243 - 250
- publisher
- Bentham Science Publishers
- external identifiers
-
- wos:000189112000004
- scopus:1242306802
- ISSN
- 1385-2728
- language
- English
- LU publication?
- yes
- id
- d26f0612-cc77-479e-a38c-d2f6184af8b5 (old id 286770)
- alternative location
- http://www.ingentaconnect.com/content/ben/coc/2004/00000008/00000003/art00004
- date added to LUP
- 2016-04-01 11:39:30
- date last changed
- 2022-01-26 08:16:53
@article{d26f0612-cc77-479e-a38c-d2f6184af8b5, abstract = {{The area of isothermal titration microcalorimetric (ITC) studies on solution systems involving nucleotides is reviewed. 62 references are cited. About 25 ITC studies on nucleotide systems have been published during the last two decades. The main part (ca 95%) of these papers deal with nucleotide-protein interactions and one paper involves nucleotide-nucleotide binding studies. The results of such studies include stoichiometry, the (concentration) binding constant, K-b, the enthalpy of binding, DeltaH(b)degrees, the standard Gibbs free energy of binding, DeltaG(b)degrees, the entropy of binding, DeltaS(b)degrees, and the heat capacity of binding at constant pressure, DeltaC(p)degrees. Information on proton uptake/release upon complex formation, modeling on binding cooperativity and conformational change can also be derived. In binding studies, calorimetric DeltaC(p)degrees and DeltaH(b)degrees data have been used to model the change in apolar and polar solvent accessible surface areas, DeltaASA(npol) and DeltaASA(pol) respectively.}}, author = {{Stödeman, Magnus}}, issn = {{1385-2728}}, language = {{eng}}, number = {{3}}, pages = {{243--250}}, publisher = {{Bentham Science Publishers}}, series = {{Current Organic Chemistry}}, title = {{Scope of nucleotide chemistry as studied by isothermal titration microcalorimetry}}, url = {{http://www.ingentaconnect.com/content/ben/coc/2004/00000008/00000003/art00004}}, volume = {{8}}, year = {{2004}}, }