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Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L

Larsson, A; Malm, Johan LU ; Grubb, Anders LU and Hansson, L O (2004) In Scandinavian Journal of Clinical & Laboratory Investigation 64(1). p.25-30
Abstract
The Cockcroft-Gault formula is often used to calculate the glomerular filtration rate (GFR) from plasma creatinine results. In Sweden this calculation is not usually done in the laboratory, but locally in the wards. These manual calculations could cause erroneous results. In several studies plasma cystatin C has been shown to be superior to plasma creatinine for estimation of GFR. One limitation of using cystatin C as a GFR marker is that there is no conversion formula transforming cystatin C expressed as mg/L to GFR expressed as mL/min. In this study plasma creatinine and cystatin C were compared with iohexol clearance. A stronger correlation (p<0.0001) was found between cystatin C and iohexol clearance (r(2) =0.91) than between... (More)
The Cockcroft-Gault formula is often used to calculate the glomerular filtration rate (GFR) from plasma creatinine results. In Sweden this calculation is not usually done in the laboratory, but locally in the wards. These manual calculations could cause erroneous results. In several studies plasma cystatin C has been shown to be superior to plasma creatinine for estimation of GFR. One limitation of using cystatin C as a GFR marker is that there is no conversion formula transforming cystatin C expressed as mg/L to GFR expressed as mL/min. In this study plasma creatinine and cystatin C were compared with iohexol clearance. A stronger correlation (p<0.0001) was found between cystatin C and iohexol clearance (r(2) =0.91) than between creatinine and iohexol clearance (r(2) =0.84). From the correlation data a formula was calculated to convert cystatin C expressed as mg/L to GFR (mL/min). The formulas y=77.24x -1.2623 (Dade Behring cystatin C calibration) or y=99.43x -1.5837 (DakoCytomation cystatin C calibration) are used to calculate GFR expressed in mL/min from the cystatin C value in mg/L and both results are reported to the referral doctor. These formulas can provide the clinicians with reliable and readily available GFR data based on single measurements of cystatin C concentrations. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glomerular filtration ratio, creatinine, cystatin C, iohexol, kidney
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
64
issue
1
pages
25 - 30
publisher
Informa Healthcare
external identifiers
  • pmid:15025426
  • wos:000188940500005
  • scopus:1442290238
ISSN
1502-7686
DOI
10.1080/00365510410003723
language
English
LU publication?
yes
id
1938ebb6-12df-4592-af9f-f2787dd528de (old id 286915)
date added to LUP
2007-10-24 08:14:16
date last changed
2017-12-03 03:42:28
@article{1938ebb6-12df-4592-af9f-f2787dd528de,
  abstract     = {The Cockcroft-Gault formula is often used to calculate the glomerular filtration rate (GFR) from plasma creatinine results. In Sweden this calculation is not usually done in the laboratory, but locally in the wards. These manual calculations could cause erroneous results. In several studies plasma cystatin C has been shown to be superior to plasma creatinine for estimation of GFR. One limitation of using cystatin C as a GFR marker is that there is no conversion formula transforming cystatin C expressed as mg/L to GFR expressed as mL/min. In this study plasma creatinine and cystatin C were compared with iohexol clearance. A stronger correlation (p&lt;0.0001) was found between cystatin C and iohexol clearance (r(2) =0.91) than between creatinine and iohexol clearance (r(2) =0.84). From the correlation data a formula was calculated to convert cystatin C expressed as mg/L to GFR (mL/min). The formulas y=77.24x -1.2623 (Dade Behring cystatin C calibration) or y=99.43x -1.5837 (DakoCytomation cystatin C calibration) are used to calculate GFR expressed in mL/min from the cystatin C value in mg/L and both results are reported to the referral doctor. These formulas can provide the clinicians with reliable and readily available GFR data based on single measurements of cystatin C concentrations.},
  author       = {Larsson, A and Malm, Johan and Grubb, Anders and Hansson, L O},
  issn         = {1502-7686},
  keyword      = {glomerular filtration ratio,creatinine,cystatin C,iohexol,kidney},
  language     = {eng},
  number       = {1},
  pages        = {25--30},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L},
  url          = {http://dx.doi.org/10.1080/00365510410003723},
  volume       = {64},
  year         = {2004},
}