Oscillations in cortico-basal ganglia circuits : implications for Parkinson's disease and other neurologic and psychiatric conditions
(2019) In Journal of Neurophysiology 122(1). p.203-231- Abstract
Cortico-basal ganglia circuits are thought to play a crucial role in the selection and control of motor behaviors and have also been implicated in the processing of motivational content and in higher cognitive functions. During the last two decades, electrophysiological recordings in basal ganglia circuits have shown that several disease conditions are associated with specific changes in the temporal patterns of neuronal activity. In particular, synchronized oscillations have been a frequent finding suggesting that excessive synchronization of neuronal activity may be a pathophysiological mechanism involved in a wide range of neurologic and psychiatric conditions. We here review the experimental support for this hypothesis primarily in... (More)
Cortico-basal ganglia circuits are thought to play a crucial role in the selection and control of motor behaviors and have also been implicated in the processing of motivational content and in higher cognitive functions. During the last two decades, electrophysiological recordings in basal ganglia circuits have shown that several disease conditions are associated with specific changes in the temporal patterns of neuronal activity. In particular, synchronized oscillations have been a frequent finding suggesting that excessive synchronization of neuronal activity may be a pathophysiological mechanism involved in a wide range of neurologic and psychiatric conditions. We here review the experimental support for this hypothesis primarily in relation to Parkinson's disease but also in relation to dystonia, essential tremor, epilepsy, and psychosis/schizophrenia.
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- author
- Halje, Pär LU ; Brys, Ivani LU ; Mariman, Juan J. ; da Cunha, Claudio ; Fuentes, Romulo and Petersson, Per LU
- organization
- publishing date
- 2019-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- integrative neurophysiology, synchrony, systems level
- in
- Journal of Neurophysiology
- volume
- 122
- issue
- 1
- pages
- 29 pages
- publisher
- American Physiological Society
- external identifiers
-
- scopus:85069236801
- pmid:31042442
- ISSN
- 0022-3077
- DOI
- 10.1152/jn.00590.2018
- language
- English
- LU publication?
- yes
- id
- 287041db-60d0-4c15-bbad-e2721e5d2c5c
- date added to LUP
- 2019-07-26 12:17:21
- date last changed
- 2024-06-11 22:32:33
@article{287041db-60d0-4c15-bbad-e2721e5d2c5c,
abstract = {{<p>Cortico-basal ganglia circuits are thought to play a crucial role in the selection and control of motor behaviors and have also been implicated in the processing of motivational content and in higher cognitive functions. During the last two decades, electrophysiological recordings in basal ganglia circuits have shown that several disease conditions are associated with specific changes in the temporal patterns of neuronal activity. In particular, synchronized oscillations have been a frequent finding suggesting that excessive synchronization of neuronal activity may be a pathophysiological mechanism involved in a wide range of neurologic and psychiatric conditions. We here review the experimental support for this hypothesis primarily in relation to Parkinson's disease but also in relation to dystonia, essential tremor, epilepsy, and psychosis/schizophrenia.</p>}},
author = {{Halje, Pär and Brys, Ivani and Mariman, Juan J. and da Cunha, Claudio and Fuentes, Romulo and Petersson, Per}},
issn = {{0022-3077}},
keywords = {{integrative neurophysiology; synchrony; systems level}},
language = {{eng}},
number = {{1}},
pages = {{203--231}},
publisher = {{American Physiological Society}},
series = {{Journal of Neurophysiology}},
title = {{Oscillations in cortico-basal ganglia circuits : implications for Parkinson's disease and other neurologic and psychiatric conditions}},
url = {{http://dx.doi.org/10.1152/jn.00590.2018}},
doi = {{10.1152/jn.00590.2018}},
volume = {{122}},
year = {{2019}},
}