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Association between nasal and bronchial symptoms in subjects with persistent allergic rhinitis

Downie, SR; Andersson, Morgan LU ; Rimmer, J; Leuppi, JD; Xuan, W; Akerlund, A; Peat, JK and Salome, CM (2004) In Allergy 59(3). p.320-326
Abstract
Background: The association between nasal and bronchial symptoms, and the course of bronchial responsiveness and airway inflammation in house dust mite sensitive persistent rhinitis over a prolonged time period has not been thoroughly explored. Objective: To determine if nasal symptoms were associated with bronchial symptoms in persistent rhinitic subjects, and to assess their bronchial responsiveness and airway inflammation in comparison to nonrhinitic, nonatopic controls. The additional impact of pollen sensitivity on the lower airways in rhinitic subjects was also addressed. Methods: Rhinitics and controls answered telephone symptom questionnaires once every 2 weeks for 1 year. Every 3 months, exhaled nitric oxide (eNO) and bronchial... (More)
Background: The association between nasal and bronchial symptoms, and the course of bronchial responsiveness and airway inflammation in house dust mite sensitive persistent rhinitis over a prolonged time period has not been thoroughly explored. Objective: To determine if nasal symptoms were associated with bronchial symptoms in persistent rhinitic subjects, and to assess their bronchial responsiveness and airway inflammation in comparison to nonrhinitic, nonatopic controls. The additional impact of pollen sensitivity on the lower airways in rhinitic subjects was also addressed. Methods: Rhinitics and controls answered telephone symptom questionnaires once every 2 weeks for 1 year. Every 3 months, exhaled nitric oxide (eNO) and bronchial responsiveness to histamine were measured. Results: Thirty-seven rhinitics and 19 controls completed the study. High nasal symptom scores in rhinitic subjects were associated with bronchial symptoms (OR = 1.7, 95% CI 1.2-2.5). Bronchial hyper-responsiveness was present in 32.4% of rhinitic subjects on at least one clinical visit during the year. Pollen allergy caused seasonal variation in eNO (P = 0.03). Conclusion: In persistent rhinitic subjects, high nasal symptom scores were associated with bronchial symptoms, and many subjects experienced bronchial hyper-responsiveness during the year. Persistent rhinitic subjects were more at risk than healthy adults of bronchial symptoms and airway inflammation, which are likely risk factors for asthma. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
nasal symptoms, house dust mite, bronchial hyper-responsiveness, bronchial symptoms, persistent rhinitis
in
Allergy
volume
59
issue
3
pages
320 - 326
publisher
Wiley-Blackwell
external identifiers
  • pmid:14982515
  • wos:000188988300010
  • scopus:1542510015
ISSN
1398-9995
DOI
10.1111/j.1398-9995.2003.00419.x
language
English
LU publication?
yes
id
dc543e4a-ee84-4354-94e1-300ab8de5421 (old id 287446)
date added to LUP
2007-08-02 12:28:26
date last changed
2017-11-12 04:04:55
@article{dc543e4a-ee84-4354-94e1-300ab8de5421,
  abstract     = {Background: The association between nasal and bronchial symptoms, and the course of bronchial responsiveness and airway inflammation in house dust mite sensitive persistent rhinitis over a prolonged time period has not been thoroughly explored. Objective: To determine if nasal symptoms were associated with bronchial symptoms in persistent rhinitic subjects, and to assess their bronchial responsiveness and airway inflammation in comparison to nonrhinitic, nonatopic controls. The additional impact of pollen sensitivity on the lower airways in rhinitic subjects was also addressed. Methods: Rhinitics and controls answered telephone symptom questionnaires once every 2 weeks for 1 year. Every 3 months, exhaled nitric oxide (eNO) and bronchial responsiveness to histamine were measured. Results: Thirty-seven rhinitics and 19 controls completed the study. High nasal symptom scores in rhinitic subjects were associated with bronchial symptoms (OR = 1.7, 95% CI 1.2-2.5). Bronchial hyper-responsiveness was present in 32.4% of rhinitic subjects on at least one clinical visit during the year. Pollen allergy caused seasonal variation in eNO (P = 0.03). Conclusion: In persistent rhinitic subjects, high nasal symptom scores were associated with bronchial symptoms, and many subjects experienced bronchial hyper-responsiveness during the year. Persistent rhinitic subjects were more at risk than healthy adults of bronchial symptoms and airway inflammation, which are likely risk factors for asthma.},
  author       = {Downie, SR and Andersson, Morgan and Rimmer, J and Leuppi, JD and Xuan, W and Akerlund, A and Peat, JK and Salome, CM},
  issn         = {1398-9995},
  keyword      = {nasal symptoms,house dust mite,bronchial hyper-responsiveness,bronchial symptoms,persistent rhinitis},
  language     = {eng},
  number       = {3},
  pages        = {320--326},
  publisher    = {Wiley-Blackwell},
  series       = {Allergy},
  title        = {Association between nasal and bronchial symptoms in subjects with persistent allergic rhinitis},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.2003.00419.x},
  volume       = {59},
  year         = {2004},
}