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COPD exacerbations: the importance of a standard definition

Pauwels, R; Calverley, P; Buist, AS; Rennard, S; Fukuchi, Y; Ståhl, Erik LU and Lofdahl, CG (2004) In Respiratory Medicine 98(2). p.99-107
Abstract
Efforts to assess the efficacy of new therapies in the treatment of acute exacerbations of chronic obstructive pulmonary disease (COPD) have been hampered by the lack of a widely agreed and consistently used definition. A variety of definitions have been used in clinical studies, based on changes in patient symptoms or the requirement for antibiotic therapy, oral steroids or hospitalisation. To date, none of these definitions have been assessed in detail for their reliability, responsiveness and validity determined. Considerable heterogeneity in the aetiology and manifestation of COPD exacerbations makes identification and quantification of defining symptoms extremely difficult. New approaches are therefore being sought with a view to... (More)
Efforts to assess the efficacy of new therapies in the treatment of acute exacerbations of chronic obstructive pulmonary disease (COPD) have been hampered by the lack of a widely agreed and consistently used definition. A variety of definitions have been used in clinical studies, based on changes in patient symptoms or the requirement for antibiotic therapy, oral steroids or hospitalisation. To date, none of these definitions have been assessed in detail for their reliability, responsiveness and validity determined. Considerable heterogeneity in the aetiology and manifestation of COPD exacerbations makes identification and quantification of defining symptoms extremely difficult. New approaches are therefore being sought with a view to identifying a serum or tissue marker that can be used as a valuable diagnostic tool Improvements in data recording will also contribute to the accuracy of data retrieval and assessment. if we are to progress to a level of sophistication seen in the diagnosis and management of other diseases, it is evident that considerable research efforts will be required to improve our understanding of COPD exacerbations and develop a standard definition for these events, thereby facilitating the assessment of therapeutic approaches. (C) 2003 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
definition, COPD, exacerbation
in
Respiratory Medicine
volume
98
issue
2
pages
99 - 107
publisher
Elsevier
external identifiers
  • wos:000188815200002
  • pmid:14971871
  • scopus:0842302411
ISSN
1532-3064
DOI
10.1016/j.rmed.2003.09.001
language
English
LU publication?
yes
id
130e9281-62a3-4c9b-b87d-9edc93ee8daf (old id 287523)
date added to LUP
2007-10-29 14:47:09
date last changed
2017-12-10 04:32:47
@article{130e9281-62a3-4c9b-b87d-9edc93ee8daf,
  abstract     = {Efforts to assess the efficacy of new therapies in the treatment of acute exacerbations of chronic obstructive pulmonary disease (COPD) have been hampered by the lack of a widely agreed and consistently used definition. A variety of definitions have been used in clinical studies, based on changes in patient symptoms or the requirement for antibiotic therapy, oral steroids or hospitalisation. To date, none of these definitions have been assessed in detail for their reliability, responsiveness and validity determined. Considerable heterogeneity in the aetiology and manifestation of COPD exacerbations makes identification and quantification of defining symptoms extremely difficult. New approaches are therefore being sought with a view to identifying a serum or tissue marker that can be used as a valuable diagnostic tool Improvements in data recording will also contribute to the accuracy of data retrieval and assessment. if we are to progress to a level of sophistication seen in the diagnosis and management of other diseases, it is evident that considerable research efforts will be required to improve our understanding of COPD exacerbations and develop a standard definition for these events, thereby facilitating the assessment of therapeutic approaches. (C) 2003 Elsevier Ltd. All rights reserved.},
  author       = {Pauwels, R and Calverley, P and Buist, AS and Rennard, S and Fukuchi, Y and Ståhl, Erik and Lofdahl, CG},
  issn         = {1532-3064},
  keyword      = {definition,COPD,exacerbation},
  language     = {eng},
  number       = {2},
  pages        = {99--107},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {COPD exacerbations: the importance of a standard definition},
  url          = {http://dx.doi.org/10.1016/j.rmed.2003.09.001},
  volume       = {98},
  year         = {2004},
}