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Ezrin expression in rectal cancer predicts time to development of local recurrence

Jorgren, Fredrik; Nilbert, Mef LU ; Rambech, Eva LU ; Bendahl, Pär-Ola LU and Lindmark, Gudrun (2012) In International Journal of Colorectal Disease 27(7). p.893-899
Abstract
Improved outcome after rectal cancer surgery requires identification of novel risk factors of tumour recurrence in order to personalise therapy, that is, enhanced selection of high-risk patients to additional radiochemotherapy or intensified follow-up. In several tumour types, including colorectal cancer, high expression of the membrane-cytoskeleton linker ezrin has been suggested to impair prognosis but has not yet reached clinical application. We evaluated the expression of ezrin in rectal cancer with a focus on the identification of a marker for local tumour recurrence. Immunohistochemical expression of ezrin was analysed in 104 primary rectal cancers from patients who developed local recurrences despite being treated with R0 major... (More)
Improved outcome after rectal cancer surgery requires identification of novel risk factors of tumour recurrence in order to personalise therapy, that is, enhanced selection of high-risk patients to additional radiochemotherapy or intensified follow-up. In several tumour types, including colorectal cancer, high expression of the membrane-cytoskeleton linker ezrin has been suggested to impair prognosis but has not yet reached clinical application. We evaluated the expression of ezrin in rectal cancer with a focus on the identification of a marker for local tumour recurrence. Immunohistochemical expression of ezrin was analysed in 104 primary rectal cancers from patients who developed local recurrences despite being treated with R0 major abdominal surgery. Time to local recurrence and distant metastasis as well as 5-year overall and cancer-specific survival were used as end points. Ezrin expression was weak in 17% of the tumours, moderate in 62%, and intense in 21%. The time to local recurrence was significantly shorter (p = 0.0004) for patients with tumours showing high ezrin expression. No correlation between ezrin expression and time to distant metastasis was identified. Survival data were similar between groups irrespective of ezrin expression in the primary tumours. Our findings suggest that increased expression of ezrin may represent a marker of aggressive biological behaviour in rectal cancer. Although further validation is needed, ezrin may represent a relevant marker for personalised treatment of rectal cancer with respect to risk of local recurrence after R0 surgery. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ezrin, Tumour marker, Prognostic, Rectal neoplams, Neoplasm recurrence, Local, Risk factors
in
International Journal of Colorectal Disease
volume
27
issue
7
pages
893 - 899
publisher
Springer
external identifiers
  • wos:000305523500007
  • scopus:84864453305
ISSN
1432-1262
DOI
10.1007/s00384-011-1397-z
language
English
LU publication?
yes
id
5bda317b-9aef-41c5-9936-b55b9d5b4da6 (old id 2883892)
date added to LUP
2012-08-01 09:41:49
date last changed
2017-11-12 03:04:44
@article{5bda317b-9aef-41c5-9936-b55b9d5b4da6,
  abstract     = {Improved outcome after rectal cancer surgery requires identification of novel risk factors of tumour recurrence in order to personalise therapy, that is, enhanced selection of high-risk patients to additional radiochemotherapy or intensified follow-up. In several tumour types, including colorectal cancer, high expression of the membrane-cytoskeleton linker ezrin has been suggested to impair prognosis but has not yet reached clinical application. We evaluated the expression of ezrin in rectal cancer with a focus on the identification of a marker for local tumour recurrence. Immunohistochemical expression of ezrin was analysed in 104 primary rectal cancers from patients who developed local recurrences despite being treated with R0 major abdominal surgery. Time to local recurrence and distant metastasis as well as 5-year overall and cancer-specific survival were used as end points. Ezrin expression was weak in 17% of the tumours, moderate in 62%, and intense in 21%. The time to local recurrence was significantly shorter (p = 0.0004) for patients with tumours showing high ezrin expression. No correlation between ezrin expression and time to distant metastasis was identified. Survival data were similar between groups irrespective of ezrin expression in the primary tumours. Our findings suggest that increased expression of ezrin may represent a marker of aggressive biological behaviour in rectal cancer. Although further validation is needed, ezrin may represent a relevant marker for personalised treatment of rectal cancer with respect to risk of local recurrence after R0 surgery.},
  author       = {Jorgren, Fredrik and Nilbert, Mef and Rambech, Eva and Bendahl, Pär-Ola and Lindmark, Gudrun},
  issn         = {1432-1262},
  keyword      = {Ezrin,Tumour marker,Prognostic,Rectal neoplams,Neoplasm recurrence,Local,Risk factors},
  language     = {eng},
  number       = {7},
  pages        = {893--899},
  publisher    = {Springer},
  series       = {International Journal of Colorectal Disease},
  title        = {Ezrin expression in rectal cancer predicts time to development of local recurrence},
  url          = {http://dx.doi.org/10.1007/s00384-011-1397-z},
  volume       = {27},
  year         = {2012},
}