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Abnormal retinal vascular morphology in young adults following intrauterine growth restriction

Hellstrom, A; Dahlgren, J; Marsal, Karel LU and Ley, David LU (2004) In Pediatrics 113(2). p.77-80
Abstract
Objective. Intrauterine growth restriction ( IUGR) resulting in low birth weight for gestational age may predispose one to development of cardiovascular disease later in life. Abnormal fetal blood flow in the presence of fetal growth restriction helps to distinguish infants with true fetal growth impairment from small but normal infants. Our goal was to investigate associations between IUGR with abnormal fetal blood flow and abnormal retinal vascular morphology at 18 years of age. Methods. A prospective study was performed with 21 subjects with IUGR ( abnormal fetal aortic blood flow velocity; birth weight small for gestational age; median birth weight deviation from the population mean of - 31% [ range: - 22% to - 42%] and in 23 subjects... (More)
Objective. Intrauterine growth restriction ( IUGR) resulting in low birth weight for gestational age may predispose one to development of cardiovascular disease later in life. Abnormal fetal blood flow in the presence of fetal growth restriction helps to distinguish infants with true fetal growth impairment from small but normal infants. Our goal was to investigate associations between IUGR with abnormal fetal blood flow and abnormal retinal vascular morphology at 18 years of age. Methods. A prospective study was performed with 21 subjects with IUGR ( abnormal fetal aortic blood flow velocity; birth weight small for gestational age; median birth weight deviation from the population mean of - 31% [ range: - 22% to - 42%] and in 23 subjects with birth weight appropriate for gestational age [ normal fetal aortic blood flow velocity; median birth weight deviation of - 2% ( range: - 10% to 22%)]). The retinal vessel morphology was evaluated by digital image analysis. Result. Subjects with IUGR ( n = 21) had significantly less retinal vascularization as evidenced by a lower number of vascular branching points ( median: 26; range: 20 31) as compared with the subjects who were born appropriate for gestational age ( median: 28; range: 26 - 32). Within the entire group ( N = 44), increasing negative birth weight deviation was associated with a reduced number of vascular branching points ( r = 0.36. Conclusion. Our findings show that IUGR with abnormal fetal blood flow is associated with abnormal retinal vascular morphology in young adult life. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
intrauterine growth restriction, small for gestational age, abnormal, vessel morphology
in
Pediatrics
volume
113
issue
2
pages
77 - 80
publisher
American Academy of Pediatrics
external identifiers
  • pmid:14754975
  • wos:000188603800001
  • scopus:1442283080
ISSN
1098-4275
language
English
LU publication?
yes
id
cbc6e766-59a1-415d-95a8-d621614995c2 (old id 288573)
date added to LUP
2007-08-02 14:58:35
date last changed
2017-10-01 04:41:12
@article{cbc6e766-59a1-415d-95a8-d621614995c2,
  abstract     = {Objective. Intrauterine growth restriction ( IUGR) resulting in low birth weight for gestational age may predispose one to development of cardiovascular disease later in life. Abnormal fetal blood flow in the presence of fetal growth restriction helps to distinguish infants with true fetal growth impairment from small but normal infants. Our goal was to investigate associations between IUGR with abnormal fetal blood flow and abnormal retinal vascular morphology at 18 years of age. Methods. A prospective study was performed with 21 subjects with IUGR ( abnormal fetal aortic blood flow velocity; birth weight small for gestational age; median birth weight deviation from the population mean of - 31% [ range: - 22% to - 42%] and in 23 subjects with birth weight appropriate for gestational age [ normal fetal aortic blood flow velocity; median birth weight deviation of - 2% ( range: - 10% to 22%)]). The retinal vessel morphology was evaluated by digital image analysis. Result. Subjects with IUGR ( n = 21) had significantly less retinal vascularization as evidenced by a lower number of vascular branching points ( median: 26; range: 20 31) as compared with the subjects who were born appropriate for gestational age ( median: 28; range: 26 - 32). Within the entire group ( N = 44), increasing negative birth weight deviation was associated with a reduced number of vascular branching points ( r = 0.36. Conclusion. Our findings show that IUGR with abnormal fetal blood flow is associated with abnormal retinal vascular morphology in young adult life.},
  author       = {Hellstrom, A and Dahlgren, J and Marsal, Karel and Ley, David},
  issn         = {1098-4275},
  keyword      = {intrauterine growth restriction,small for gestational age,abnormal,vessel morphology},
  language     = {eng},
  number       = {2},
  pages        = {77--80},
  publisher    = {American Academy of Pediatrics},
  series       = {Pediatrics},
  title        = {Abnormal retinal vascular morphology in young adults following intrauterine growth restriction},
  volume       = {113},
  year         = {2004},
}