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Role of Tobacco Use in the Etiology of Acoustic Neuroma

Palmisano, Sadie; Schwartzbaum, Judith; Prochazka, Michaela; Pettersson, David; Bergenheim, Tommy; Florentzson, Rut; Harder, Henrik; Mathiesen, Tiit; Nyberg, Gunnar and Siesjö, Peter LU , et al. (2012) In American Journal of Epidemiology 175(12). p.1243-1251
Abstract
Two previous studies suggest that cigarette smoking reduces acoustic neuroma risk; however, an association between use of snuff tobacco and acoustic neuroma has not been investigated previously. The authors conducted a case-control study in Sweden from 2002 to 2007, in which 451 cases and 710 population-based controls completed questionnaires. Cases and controls were matched on gender, region, and age within 5 years. The authors estimated odds ratios using conditional logistic regression analyses, adjusted for education and tobacco use (snuff use in the smoking analysis and smoking in the snuff analysis). The risk of acoustic neuroma was greatly reduced in male current smokers (odds ratio (OR) = 0.41, 95% confidence interval (CI): 0.23,... (More)
Two previous studies suggest that cigarette smoking reduces acoustic neuroma risk; however, an association between use of snuff tobacco and acoustic neuroma has not been investigated previously. The authors conducted a case-control study in Sweden from 2002 to 2007, in which 451 cases and 710 population-based controls completed questionnaires. Cases and controls were matched on gender, region, and age within 5 years. The authors estimated odds ratios using conditional logistic regression analyses, adjusted for education and tobacco use (snuff use in the smoking analysis and smoking in the snuff analysis). The risk of acoustic neuroma was greatly reduced in male current smokers (odds ratio (OR) = 0.41, 95% confidence interval (CI): 0.23, 0.74) and moderately reduced in female current smokers (OR = 0.70, 95% CI: 0.40, 1.23). In contrast, current snuff use among males was not associated with risk of acoustic neuroma (OR = 0.94, 95% CI: 0.57, 1.55). The authors' findings are consistent with previous reports of lower acoustic neuroma risk among current cigarette smokers than among never smokers. The absence of an association between snuff use and acoustic neuroma suggests that some constituent of tobacco smoke other than nicotine may confer protection against acoustic neuroma. (Less)
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publication status
published
subject
keywords
vestibular schwannoma, tobacco, Swedish, snus, snuff, smoking, acoustic neuroma, cigarette smoking
in
American Journal of Epidemiology
volume
175
issue
12
pages
1243 - 1251
publisher
Oxford University Press
external identifiers
  • wos:000305419400005
  • scopus:84862504913
ISSN
0002-9262
DOI
10.1093/aje/kwr465
language
English
LU publication?
yes
id
bf574d85-5503-4338-be7e-db16eb8f1df1 (old id 2887442)
date added to LUP
2012-08-01 09:41:03
date last changed
2017-10-22 03:09:12
@article{bf574d85-5503-4338-be7e-db16eb8f1df1,
  abstract     = {Two previous studies suggest that cigarette smoking reduces acoustic neuroma risk; however, an association between use of snuff tobacco and acoustic neuroma has not been investigated previously. The authors conducted a case-control study in Sweden from 2002 to 2007, in which 451 cases and 710 population-based controls completed questionnaires. Cases and controls were matched on gender, region, and age within 5 years. The authors estimated odds ratios using conditional logistic regression analyses, adjusted for education and tobacco use (snuff use in the smoking analysis and smoking in the snuff analysis). The risk of acoustic neuroma was greatly reduced in male current smokers (odds ratio (OR) = 0.41, 95% confidence interval (CI): 0.23, 0.74) and moderately reduced in female current smokers (OR = 0.70, 95% CI: 0.40, 1.23). In contrast, current snuff use among males was not associated with risk of acoustic neuroma (OR = 0.94, 95% CI: 0.57, 1.55). The authors' findings are consistent with previous reports of lower acoustic neuroma risk among current cigarette smokers than among never smokers. The absence of an association between snuff use and acoustic neuroma suggests that some constituent of tobacco smoke other than nicotine may confer protection against acoustic neuroma.},
  author       = {Palmisano, Sadie and Schwartzbaum, Judith and Prochazka, Michaela and Pettersson, David and Bergenheim, Tommy and Florentzson, Rut and Harder, Henrik and Mathiesen, Tiit and Nyberg, Gunnar and Siesjö, Peter and Feychting, Maria},
  issn         = {0002-9262},
  keyword      = {vestibular schwannoma,tobacco,Swedish,snus,snuff,smoking,acoustic neuroma,cigarette smoking},
  language     = {eng},
  number       = {12},
  pages        = {1243--1251},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Role of Tobacco Use in the Etiology of Acoustic Neuroma},
  url          = {http://dx.doi.org/10.1093/aje/kwr465},
  volume       = {175},
  year         = {2012},
}