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Pest control compounds targeting insect chemoreceptors: Another silent spring?

Andersson, Martin N LU and Newcomb, Richard D. (2017) In Frontiers in Ecology and Evolution 5.
Abstract
An emerging concept in the ongoing battle against insect pests is that compounds that
influence the behavior of insects by modulating their ability to smell could be developed
by targeting their chemoreceptors. This idea was identified by the annual horizon scan of
global conservation issues as a topic of concern for their 2015 report. Unfortunately, the
publication could only afford a short discussion of the pros and cons of the approach.
Here we review the concept and discuss how it might be best implemented to avoid
potential off-target effects and environmental harm. We describe the first of this class
of compounds, VUAA1, outlining that its highly broad range of potential insect targets
would lead to... (More)
An emerging concept in the ongoing battle against insect pests is that compounds that
influence the behavior of insects by modulating their ability to smell could be developed
by targeting their chemoreceptors. This idea was identified by the annual horizon scan of
global conservation issues as a topic of concern for their 2015 report. Unfortunately, the
publication could only afford a short discussion of the pros and cons of the approach.
Here we review the concept and discuss how it might be best implemented to avoid
potential off-target effects and environmental harm. We describe the first of this class
of compounds, VUAA1, outlining that its highly broad range of potential insect targets
would lead to many of the issues associated with broad-spectrum insecticides. We
also review compounds and approaches targeting the relatively less conserved carbon
dioxide receptor complex and finally highly tuned receptors to conclude that focusing on
species-specific pheromone receptors would result in fewer potential off-target effects. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
insect chemoreceptor, Off-target effects, VUAA1
in
Frontiers in Ecology and Evolution
volume
5
pages
6 pages
publisher
Frontiers
external identifiers
  • scopus:85020043729
ISSN
2296-701X
DOI
10.3389/fevo.2017.00005
language
English
LU publication?
yes
id
288c3b32-121f-4f71-b54a-e9487afdfbd8
date added to LUP
2017-04-10 17:01:00
date last changed
2018-10-03 12:09:25
@article{288c3b32-121f-4f71-b54a-e9487afdfbd8,
  abstract     = {An emerging concept in the ongoing battle against insect pests is that compounds that<br/>influence the behavior of insects by modulating their ability to smell could be developed<br/>by targeting their chemoreceptors. This idea was identified by the annual horizon scan of<br/>global conservation issues as a topic of concern for their 2015 report. Unfortunately, the<br/>publication could only afford a short discussion of the pros and cons of the approach.<br/>Here we review the concept and discuss how it might be best implemented to avoid<br/>potential off-target effects and environmental harm. We describe the first of this class<br/>of compounds, VUAA1, outlining that its highly broad range of potential insect targets<br/>would lead to many of the issues associated with broad-spectrum insecticides. We<br/>also review compounds and approaches targeting the relatively less conserved carbon<br/>dioxide receptor complex and finally highly tuned receptors to conclude that focusing on<br/>species-specific pheromone receptors would result in fewer potential off-target effects.},
  articleno    = {5},
  author       = {Andersson, Martin N and Newcomb, Richard D.},
  issn         = {2296-701X},
  keyword      = {insect chemoreceptor,Off-target effects,VUAA1},
  language     = {eng},
  month        = {02},
  pages        = {6},
  publisher    = {Frontiers},
  series       = {Frontiers in Ecology and Evolution},
  title        = {Pest control compounds targeting insect chemoreceptors: Another silent spring?},
  url          = {http://dx.doi.org/10.3389/fevo.2017.00005},
  volume       = {5},
  year         = {2017},
}