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Evaluation of microwave thermotherapy with histopathology, magnetic resonance imaging and temperature mapping

Huidobro, C; Bolmsjo, M; Larson, T; De la Rosette, J; Wagrell, L; Schelin, S; Gorecki, T and Mattiasson, Anders LU (2004) In Journal of Urology 171(2). p.672-678
Abstract
Purpose: Interstitial temperature mapping was used to determine the heat field within the prostate by the Coretherm. (ProstaLund, Lund, Sweden) transurethral microwave thermotherapy device. Gadolinium. enhanced magnetic resonance imaging (MRI) and histopathology were used to determine the extent and pattern of coagulation necrosis following treatment. The cell kill assessment feature of the device was compared with MRI and histopathology. Materials and Methods: A total of 12 patients were treated, including 5 with adenocarcinoma of the prostate and 7 with benign prostatic hyperplasia. Temperature sensors were inserted from the perineum. to map the temperature distribution. The 5 patients with adenocarcinoma underwent prostatectomy and... (More)
Purpose: Interstitial temperature mapping was used to determine the heat field within the prostate by the Coretherm. (ProstaLund, Lund, Sweden) transurethral microwave thermotherapy device. Gadolinium. enhanced magnetic resonance imaging (MRI) and histopathology were used to determine the extent and pattern of coagulation necrosis following treatment. The cell kill assessment feature of the device was compared with MRI and histopathology. Materials and Methods: A total of 12 patients were treated, including 5 with adenocarcinoma of the prostate and 7 with benign prostatic hyperplasia. Temperature sensors were inserted from the perineum. to map the temperature distribution. The 5 patients with adenocarcinoma underwent prostatectomy and subsequent histopathology 3 to 6 weeks after treatment. MRI and cell kill calculations were performed in all patients. Results: Therapeutic temperatures were found in a bowl-like shape with a wide circumference of highest temperatures at the base of the prostate, and decreasing temperature and circumference toward the apex. Tissue necrosis assessed by histopathology, MRI and cell kill calculations overlapped reasonably well in shape and size. Histopathology showed that the prostatic urethra was destroyed by treatment. Conclusions: Coretherm microwave treatment causes significant tissue necrosis of the prostate, bladder neck and urethral mucosa. The cell kill calculation provides an on-line estimate of the amount of necrosis caused during treatment. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
microwaves, necrosis, prostatic hypertrophy, prostate, prostatic neoplasms
in
Journal of Urology
volume
171
issue
2
pages
672 - 678
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000188319300026
  • pmid:14713784
  • scopus:0347759862
ISSN
1527-3792
DOI
10.1097/01.ju.0000108136.41620.95
language
English
LU publication?
yes
id
175a4b1d-1f6a-4c65-a420-878bd9697105 (old id 289673)
date added to LUP
2007-11-01 11:44:28
date last changed
2017-02-22 11:44:31
@article{175a4b1d-1f6a-4c65-a420-878bd9697105,
  abstract     = {Purpose: Interstitial temperature mapping was used to determine the heat field within the prostate by the Coretherm. (ProstaLund, Lund, Sweden) transurethral microwave thermotherapy device. Gadolinium. enhanced magnetic resonance imaging (MRI) and histopathology were used to determine the extent and pattern of coagulation necrosis following treatment. The cell kill assessment feature of the device was compared with MRI and histopathology. Materials and Methods: A total of 12 patients were treated, including 5 with adenocarcinoma of the prostate and 7 with benign prostatic hyperplasia. Temperature sensors were inserted from the perineum. to map the temperature distribution. The 5 patients with adenocarcinoma underwent prostatectomy and subsequent histopathology 3 to 6 weeks after treatment. MRI and cell kill calculations were performed in all patients. Results: Therapeutic temperatures were found in a bowl-like shape with a wide circumference of highest temperatures at the base of the prostate, and decreasing temperature and circumference toward the apex. Tissue necrosis assessed by histopathology, MRI and cell kill calculations overlapped reasonably well in shape and size. Histopathology showed that the prostatic urethra was destroyed by treatment. Conclusions: Coretherm microwave treatment causes significant tissue necrosis of the prostate, bladder neck and urethral mucosa. The cell kill calculation provides an on-line estimate of the amount of necrosis caused during treatment.},
  author       = {Huidobro, C and Bolmsjo, M and Larson, T and De la Rosette, J and Wagrell, L and Schelin, S and Gorecki, T and Mattiasson, Anders},
  issn         = {1527-3792},
  keyword      = {microwaves,necrosis,prostatic hypertrophy,prostate,prostatic neoplasms},
  language     = {eng},
  number       = {2},
  pages        = {672--678},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Urology},
  title        = {Evaluation of microwave thermotherapy with histopathology, magnetic resonance imaging and temperature mapping},
  url          = {http://dx.doi.org/10.1097/01.ju.0000108136.41620.95},
  volume       = {171},
  year         = {2004},
}