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Weight loss is effective for symptomatic relief in obese subjects with knee osteoarthritis independently of joint damage severity assessed by high-field MRI and radiography

Gudbergsen, H.; Boesen, M.; Lohmander, Stefan LU ; Christensen, R.; Henriksen, M.; Bartels, E. M.; Christensen, P.; Rindel, L.; Aaboe, J. and Danneskiold-Samsoe, B., et al. (2012) In Osteoarthritis and Cartilage 20(6). p.495-502
Abstract
Objective: With an increasing prevalence of older and obese citizens, the problems of knee osteoarthritis (KOA) will escalate. Weight loss is recommended for obese KOA patients and in a majority of cases this leads to symptomatic relief. We hypothesized that pre-treatment structural status of the knee joint, assessed by radiographs, 1.5 T magnetic resonance imaging (MRI) and knee-joint alignment, may influence the symptomatic changes following a significant weight reduction. Design: Patients were recruited from a Department of Rheumatology. Eligibility criteria were age above 50 years, body mass index >= 30 kg/m(2), primary KOA diagnosed according to the American College of Rheumatology (ACR) criteria and having verified structural... (More)
Objective: With an increasing prevalence of older and obese citizens, the problems of knee osteoarthritis (KOA) will escalate. Weight loss is recommended for obese KOA patients and in a majority of cases this leads to symptomatic relief. We hypothesized that pre-treatment structural status of the knee joint, assessed by radiographs, 1.5 T magnetic resonance imaging (MRI) and knee-joint alignment, may influence the symptomatic changes following a significant weight reduction. Design: Patients were recruited from a Department of Rheumatology. Eligibility criteria were age above 50 years, body mass index >= 30 kg/m(2), primary KOA diagnosed according to the American College of Rheumatology (ACR) criteria and having verified structural damage. Patients underwent a 16 weeks dietary programme with formula products and counselling. MRI and radiographs of the most symptomatic knee were obtained at baseline and assessed for structural damage using the Boston-Leeds Osteoarthritis of the Knee Score, minimum joint space width and Kellgren Lawrence score. Imaging variables, muscle strength and degree of alignment, were examined as predictors of changes in Knee Osteoarthritis Outcome Score (KOOS) and Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) - Osteoarthritis Research Society International (OARSI) Responder Criterion. Results: Structural damage at baseline assessed by imaging, muscle strength or knee-joint alignment showed no statistically significant association to changes in KOOS pain and function in daily living (r <= 0.13; P > 0.05) or the OMERACT-OARSI Responder Criterion (OR 0.48-1.68; P-values > 0.13). Conclusions: Presence of joint damage did not preclude symptomatic relief following a clinically relevant weight loss in older obese patients with KOA. Neither muscle strength nor knee-joint alignment was associated with the degree of symptomatic relief. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. (Less)
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publication status
published
subject
keywords
Knee osteoarthritis, Diet, BLOKS, MRI, Muscle strength, Alignment
in
Osteoarthritis and Cartilage
volume
20
issue
6
pages
495 - 502
publisher
Elsevier
external identifiers
  • wos:000304733900006
  • scopus:84860511987
ISSN
1063-4584
DOI
10.1016/j.joca.2012.02.639
language
English
LU publication?
yes
id
f1769cc4-0c89-4a3b-9cc3-1fdf5c36f82d (old id 2896975)
date added to LUP
2012-08-01 09:44:42
date last changed
2017-10-22 03:07:21
@article{f1769cc4-0c89-4a3b-9cc3-1fdf5c36f82d,
  abstract     = {Objective: With an increasing prevalence of older and obese citizens, the problems of knee osteoarthritis (KOA) will escalate. Weight loss is recommended for obese KOA patients and in a majority of cases this leads to symptomatic relief. We hypothesized that pre-treatment structural status of the knee joint, assessed by radiographs, 1.5 T magnetic resonance imaging (MRI) and knee-joint alignment, may influence the symptomatic changes following a significant weight reduction. Design: Patients were recruited from a Department of Rheumatology. Eligibility criteria were age above 50 years, body mass index &gt;= 30 kg/m(2), primary KOA diagnosed according to the American College of Rheumatology (ACR) criteria and having verified structural damage. Patients underwent a 16 weeks dietary programme with formula products and counselling. MRI and radiographs of the most symptomatic knee were obtained at baseline and assessed for structural damage using the Boston-Leeds Osteoarthritis of the Knee Score, minimum joint space width and Kellgren Lawrence score. Imaging variables, muscle strength and degree of alignment, were examined as predictors of changes in Knee Osteoarthritis Outcome Score (KOOS) and Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) - Osteoarthritis Research Society International (OARSI) Responder Criterion. Results: Structural damage at baseline assessed by imaging, muscle strength or knee-joint alignment showed no statistically significant association to changes in KOOS pain and function in daily living (r &lt;= 0.13; P &gt; 0.05) or the OMERACT-OARSI Responder Criterion (OR 0.48-1.68; P-values &gt; 0.13). Conclusions: Presence of joint damage did not preclude symptomatic relief following a clinically relevant weight loss in older obese patients with KOA. Neither muscle strength nor knee-joint alignment was associated with the degree of symptomatic relief. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.},
  author       = {Gudbergsen, H. and Boesen, M. and Lohmander, Stefan and Christensen, R. and Henriksen, M. and Bartels, E. M. and Christensen, P. and Rindel, L. and Aaboe, J. and Danneskiold-Samsoe, B. and Riecke, B. F. and Bliddal, H.},
  issn         = {1063-4584},
  keyword      = {Knee osteoarthritis,Diet,BLOKS,MRI,Muscle strength,Alignment},
  language     = {eng},
  number       = {6},
  pages        = {495--502},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {Weight loss is effective for symptomatic relief in obese subjects with knee osteoarthritis independently of joint damage severity assessed by high-field MRI and radiography},
  url          = {http://dx.doi.org/10.1016/j.joca.2012.02.639},
  volume       = {20},
  year         = {2012},
}