Responsiveness of the OARSI-OMERACT osteoarthritis pain and function measures
(2012) In Osteoarthritis and Cartilage 20(6). p.541-547- Abstract
- Objective: To assess the responsiveness of the Intermittent and Constant Osteoarthritis Pain (ICOAP) measure, Hip Disability and Osteoarthritis Outcome Score Physical Function Short Form (HOOS-PS), and the Knee Disability and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS) in a pharmacological trial. Methods: Data were obtained from a randomized double-blind trial comparing naproxcinod with naproxen and ibuprofen in individuals with hip or knee osteoarthritis (OA) (NCT00662896). Participants completed the ICOAP, HOOS-PS/KOOS-PS, and Western Ontario and McMaster Universities OA Index (WOMAC) Likert version 3.0 before and 13 weeks after treatment. In hip and knee OA participants separately, the mean pre-post treatment... (More)
- Objective: To assess the responsiveness of the Intermittent and Constant Osteoarthritis Pain (ICOAP) measure, Hip Disability and Osteoarthritis Outcome Score Physical Function Short Form (HOOS-PS), and the Knee Disability and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS) in a pharmacological trial. Methods: Data were obtained from a randomized double-blind trial comparing naproxcinod with naproxen and ibuprofen in individuals with hip or knee osteoarthritis (OA) (NCT00662896). Participants completed the ICOAP, HOOS-PS/KOOS-PS, and Western Ontario and McMaster Universities OA Index (WOMAC) Likert version 3.0 before and 13 weeks after treatment. In hip and knee OA participants separately, the mean pre-post treatment change in scores, effect size (ES) and standardized response mean (SRM) were determined for each measure by treatment arm, and for all arms combined. Results: Of 349 trial participants, 156 with knee OA and 48 with hip OA completed all measures at both time-points and were included (mean age 61 years; two-thirds female). Although there was both within treatment and between treatment variability in response, among knee OA participants, ICOAP intermittent, constant, and total scores and KOOS-PS scores showed, on average, moderate effects, with ESs ranging from 0.46 to 0.54 and SRMs from 0.49 to 0.56. Similar changes were seen for the WOMAC pain and function subscales (0.58 and 0.58, respectively). In those with hip OA, no significant improvement in symptoms was seen for any measure. Conclusion: Responsiveness to pharmaceutical intervention was demonstrated for ICOAP and KOOS-PS among participants with knee OA. Absence of treatment response precluded assessment of responsiveness in hip OA. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2896989
- author
- Bond, M. ; Davis, A. ; Lohmander, Stefan LU and Hawker, G.
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Intermittent and Constant Osteoarthritis Pain (ICOAP) measure, Hip, Disability and Osteoarthritis Outcome, Score Physical Function Short, Form (HOOS-PS), Knee Disability and Osteoarthritis Outcome, Score, Physical Function Short Form (KOOS-PS), Responsiveness
- in
- Osteoarthritis and Cartilage
- volume
- 20
- issue
- 6
- pages
- 541 - 547
- publisher
- Elsevier
- external identifiers
-
- wos:000304733900012
- scopus:84860543018
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2012.03.001
- language
- English
- LU publication?
- yes
- id
- d0d1fdb5-e54e-4653-87ff-5794a9c93102 (old id 2896989)
- date added to LUP
- 2016-04-01 10:44:25
- date last changed
- 2023-01-17 22:49:50
@article{d0d1fdb5-e54e-4653-87ff-5794a9c93102, abstract = {{Objective: To assess the responsiveness of the Intermittent and Constant Osteoarthritis Pain (ICOAP) measure, Hip Disability and Osteoarthritis Outcome Score Physical Function Short Form (HOOS-PS), and the Knee Disability and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS) in a pharmacological trial. Methods: Data were obtained from a randomized double-blind trial comparing naproxcinod with naproxen and ibuprofen in individuals with hip or knee osteoarthritis (OA) (NCT00662896). Participants completed the ICOAP, HOOS-PS/KOOS-PS, and Western Ontario and McMaster Universities OA Index (WOMAC) Likert version 3.0 before and 13 weeks after treatment. In hip and knee OA participants separately, the mean pre-post treatment change in scores, effect size (ES) and standardized response mean (SRM) were determined for each measure by treatment arm, and for all arms combined. Results: Of 349 trial participants, 156 with knee OA and 48 with hip OA completed all measures at both time-points and were included (mean age 61 years; two-thirds female). Although there was both within treatment and between treatment variability in response, among knee OA participants, ICOAP intermittent, constant, and total scores and KOOS-PS scores showed, on average, moderate effects, with ESs ranging from 0.46 to 0.54 and SRMs from 0.49 to 0.56. Similar changes were seen for the WOMAC pain and function subscales (0.58 and 0.58, respectively). In those with hip OA, no significant improvement in symptoms was seen for any measure. Conclusion: Responsiveness to pharmaceutical intervention was demonstrated for ICOAP and KOOS-PS among participants with knee OA. Absence of treatment response precluded assessment of responsiveness in hip OA. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.}}, author = {{Bond, M. and Davis, A. and Lohmander, Stefan and Hawker, G.}}, issn = {{1063-4584}}, keywords = {{Intermittent and Constant Osteoarthritis Pain (ICOAP) measure; Hip; Disability and Osteoarthritis Outcome; Score Physical Function Short; Form (HOOS-PS); Knee Disability and Osteoarthritis Outcome; Score; Physical Function Short Form (KOOS-PS); Responsiveness}}, language = {{eng}}, number = {{6}}, pages = {{541--547}}, publisher = {{Elsevier}}, series = {{Osteoarthritis and Cartilage}}, title = {{Responsiveness of the OARSI-OMERACT osteoarthritis pain and function measures}}, url = {{https://lup.lub.lu.se/search/files/2095189/3562781.pdf}}, doi = {{10.1016/j.joca.2012.03.001}}, volume = {{20}}, year = {{2012}}, }